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Chemistry

D-Index
41
Citations
5963
World Ranking
17781
National Ranking
788

Overview

Gilbert Kirsch is affiliated with the University of Lorraine in France and has a focus on interdisciplinary research combining chemistry, medicine, and molecular biology. Their work primarily investigates organic chemistry and related subfields, including molecular biology, pharmacology, hematology, and plant science.

Their research contributions span topics such as synthesis and biological activity, histone deacetylase inhibitors research, synthesis and biological evaluation, synthesis and characterization of heterocyclic compounds, synthesis of organic compounds, chemical synthesis and alkaloids, and microbial natural products and biosynthesis.

Gilbert Kirsch has contributed publications to a range of journals, with frequent appearances in:

  • Molecules
  • Journal of Molecular Structure
  • Marine Drugs
  • Pharmacological Research
  • Antioxidants

Recent relevant publications include:

  • The HDAC6 inhibitor 7b induces BCR-ABL ubiquitination and downregulation and synergizes with imatinib to trigger apoptosis in chronic myeloid leukemia, 2020, Pharmacological Research
  • Synthetic Routes to Coumarin(Benzopyrone)-Fused Five-Membered Aromatic Heterocycles Built on the α-Pyrone Moiety. Part II: Five-Membered Aromatic Rings with Multi Heteroatoms, 2021, Molecules
  • Synthesis, biological evaluation and molecular docking studies of novel 2-alkylthiopyrimidino-tacrines as anticholinesterase agents and their DFT calculations, 2020, Journal of Molecular Structure
  • Synthetic Routes to Coumarin(Benzopyrone)-Fused Five-Membered Aromatic Heterocycles Built on the α-Pyrone Moiety. Part 1: Five-Membered Aromatic Rings with One Heteroatom, 2021, Molecules
  • Coumarins: Quorum Sensing and Biofilm Formation Inhibition, 2024, Molecules

The scientist has collaborated frequently with several researchers, including:

  • Eslam R. El-Sawy
  • Ahmed B. Abdelwahab
  • Mohamed S. Abdel-Aziz
  • Marc Diederich
  • Heba Abdelmegeed

Gilbert Kirsch's research integrates chemical synthesis techniques, with a particular emphasis on heterocyclic compound synthesis and biological evaluation. Their contributions include studies on histone deacetylase inhibitors, which are relevant for cancer research, and the development of synthetic routes for coumarin-fused heterocycles.

The breadth of their work spans basic chemical synthesis to applied biomedical research, highlighting a multidisciplinary approach inherent in their fields of study. The combination of frequent publishing in chemistry and molecular biology journals reflects the versatile and collaborative nature of their research activities.

Best Publications

  • Selective non-nucleoside inhibitors of human DNA methyltransferases active in cancer including in cancer stem cells.

    Sergio Valente;Yiwei Liu;Michael Schnekenburger;Clemens Zwergel

  • Natural and Synthetic Coumarins with Effects on Inflammation.

    Gilbert Kirsch;Ahmed Bakr Abdelwahab;Patrick Chaimbault

  • Thienylpyrrole azo dyes : Synthesis, solvatochromic and electrochemical properties

    M. Manuela M. Raposo;Ana M.R.C. Sousa;A. Maurício C. Fonseca;G. Kirsch

  • Synthesis and characterization of dicyanovinyl-substituted thienylpyrroles as new nonlinear optical chromophores

    M. Manuela M. Raposo;Ana M. R. C. Sousa;G. Kirsch;P. Cardoso

  • Synthesis of donor–acceptor substituted oligothiophenes by Stille coupling

    M.Manuela M Raposo;A.Maurı́cio C Fonseca;G Kirsch

  • Synthesis of Five- and Six-Membered Heterocycles Through Palladium- Catalyzed Reactions

    G. Kirsch;S. Hesse;A. Comel

  • Aurones: interesting natural and synthetic compounds with emerging biological potential.

    Clemens Zwergel;François Gaascht;Sergio Valente;Marc Diederich

  • Heterocyclic Analogues of Carbazole Alkaloids

    Gilbert H. Kirsch

  • Synthesis and protective effects of coumarin derivatives against oxidative stress induced by doxorubicin.

    Adeline Beillerot;Juan-Carlos Rodríguez Domínguez;Gilbert Kirsch;Denyse Bagrel

  • Evaluation of the antioxidant properties of diarylamines in the benzo[b]thiophene series by free radical scavenging activity and reducing power.

    Isabel C.F.R. Ferreira;Maria João R.P. Queiroz;Miguel Vilas-Boas;Leticia M. Estevinho

  • Efficient one pot preparation of variously substituted thieno [2,3‐b] thiophene

    Alain Cornel;Gilbert Kirsch

  • Electron-diffraction study of hydrogen isotope effects in cyclohexane

    J.D. Ewbank;G. Kirsch;Lothar Schäfer

  • Coumarin polysulfides inhibit cell growth and induce apoptosis in HCT116 colon cancer cells

    Nathaniel Edward Bennett Saidu;Sergio Valente;Emilie Bana;Gilbert Kirsch

  • Antifungal activity of synthetic di(hetero)arylamines based on the benzo[b]thiophene moiety

    Eugénia Pinto;Maria-João R.P. Queiroz;Luís A. Vale-Silva;João F. Oliveira

  • A rapid access to coumarin derivatives (using Vilsmeier–Haack and Suzuki cross-coupling reactions)

    Unknown

  • Palladium-catalyzed amination and cyclization to heteroannellated indoles and carbazoles

    Isabel C.F.R. Ferreira;Maria João R.P. Queiroz;Gilbert Kirsch

  • Design, synthesis and biological evaluation of new classes of thieno[3,2-d]pyrimidinone and thieno[1,2,3]triazine as inhibitor of vascular endothelial growth factor receptor-2 (VEGFR-2).

    Enrico Perspicace;Valérie Jouan-Hureaux;Rino Ragno;Flavio Ballante

  • Formylation, dicyanovinylation and tricyanovinylation of 5-alkoxy- and 5-amino- substituted 2,2′-bithiophenes

    M.Manuela M Raposo;G Kirsch

  • Synthesis of 5-aryl-5´-formyl-2,2´-bithiophenes as new precursors for nonlinear optical (NLO) materials

    Cyril Herbivo;Alain Comel;G. Kirsch;M. Manuela M. Raposo

  • Antiproliferative effect of natural tetrasulfides in human breast cancer cells is mediated through the inhibition of the cell division cycle 25 phosphatases

    Elodie Viry;Awais Anwar;Gilbert Kirsch;Claus Jacob

  • Palladium-Catalysed Amination of Electron-Deficient or Relatively Electron-Rich Benzo[b]thienyl Bromides − Preliminary Studies of Antimicrobial Activity and SARs

    Maria João R.P. Queiroz;Agathe Begouin;Agathe Begouin;Isabel C.F.R. Ferreira;Gilbert Kirsch

  • Novel synthetic routes to thienocarbazoles via palladium or copper catalyzed amination or amidation of arylhalides and intramolecular cyclization

    Isabel C.F.R. Ferreira;Maria João R.P. Queiroz;Gilbert Kirsch

  • Recent advances in redox active plant and microbial products : from basic chemistry to widespread applications in medicine and agriculture

    Claus Jacob;Alan Slusarenko;Gilbert Kirsch;Paul G. Winyard

Frequent Co-Authors

M. Manuela M. Raposo
M. Manuela M. Raposo University of Minho
Sergio Valente
Sergio Valente Sapienza University of Rome
Claus Jacob
Claus Jacob Saarland University
Isabel C.F.R. Ferreira
Isabel C.F.R. Ferreira Polytechnic Institute of Bragança
Marc Diederich
Marc Diederich Seoul National University
Artur M. S. Silva
Artur M. S. Silva University of Aveiro
Antonello Mai
Antonello Mai Sapienza University of Rome
Filipe A. Almeida Paz
Filipe A. Almeida Paz University of Aveiro
Mario Dicato
Mario Dicato Centre Hospitalier de Luxembourg
Leticia M. Estevinho
Leticia M. Estevinho Instituto Politécnico Nacional

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