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Biology and Biochemistry

D-Index
55
Citations
9255
World Ranking
15213
National Ranking
477

Overview

Sergio Valente is affiliated with Sapienza University of Rome in Italy. Their research spans multiple fields within the life sciences, with a focus on biochemistry, genetics, molecular biology, and medicine.

Their work covers a broad range of topics including:

  • Histone Deacetylase Inhibitors Research
  • Epigenetics and DNA Methylation
  • Sirtuins and Resveratrol in Medicine
  • Protein Degradation and Inhibitors
  • Autophagy in Disease and Therapy
  • Peptidase Inhibition and Analysis
  • Cancer-related gene regulation

Valente's publications have appeared in various scientific journals. Frequent publication venues include:

  • Journal of Medicinal Chemistry
  • ChemMedChem
  • Frontiers in Pharmacology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • ACS Infectious Diseases

Their recent papers cover topics related to drug design, cancer therapies, and biochemical mechanisms, for example:

  • GreenMedChem: the challenge in the next decade toward eco-friendly compounds and processes in drug design, 2023, Green Chemistry
  • The Innovative Potential of Statins in Cancer: New Targets for New Therapies, 2020, Frontiers in Chemistry
  • Metabolic Rewiring by Loss of Sirt5 Promotes Kras-Induced Pancreatic Cancer Progression, 2021, Gastroenterology
  • A closer look into NADPH oxidase inhibitors: Validation and insight into their mechanism of action, 2020, Redox Biology
  • Targeting the scaffolding role of LSD1 (KDM1A) poises acute myeloid leukemia cells for retinoic acid-induced differentiation, 2020, Science Advances

Frequent collaborators in Valente's research include:

  • Antonello Mai
  • Clemens Zwergel
  • Rossella Fioravanti
  • Dante Rotili
  • Elisabetta Di Bello

The scholar's main fields of study include Biochemistry, Genetics and Molecular Biology with 95 publications, followed by Medicine with 60 publications. Within these broader fields, subfields such as Molecular Biology, Epidemiology, Geriatrics and Gerontology, Immunology, and Oncology are represented in their work.

Best Publications

  • Histone deacetylation in epigenetics: An attractive target for anticancer therapy

    Antonello Mai;Silvio Massa;Dante Rotili;Ilaria Cerbara

  • TNF/p38α/Polycomb Signaling to Pax7 Locus in Satellite Cells Links Inflammation to the Epigenetic Control of Muscle Regeneration

    Daniela Palacios;Chiara Mozzetta;Silvia Consalvi;Giuseppina Caretti;Giuseppina Caretti

  • Biochemical, Structural, and Biological Evaluation of Tranylcypromine Derivatives as Inhibitors of Histone Demethylases LSD1 and LSD2

    Claudia Binda;Sergio Valente;Mauro Romanenghi;Simona Pilotto

  • Oxidative Stress and Epigenetic Regulation in Ageing and Age-Related Diseases

    Chiara Cencioni;Francesco Spallotta;Fabio Martelli;Sergio Valente

  • Inhibition of Class I Histone Deacetylases Unveils a Mitochondrial Signature and Enhances Oxidative Metabolism in Skeletal Muscle and Adipose Tissue

    Andrea Galmozzi;Nico Mitro;Alessandra Ferrari;Elise Gers

  • Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors

    Jay H. Kalin;Jay H. Kalin;Muzhou Wu;Andrea V. Gomez;Yun Song

  • Selective class II HDAC inhibitors impair myogenesis by modulating the stability and activity of HDAC–MEF2 complexes

    Angela Nebbioso;Fabio Manzo;Marco Miceli;Mariarosaria Conte

  • Study of 1,4-Dihydropyridine Structural Scaffold: Discovery of Novel Sirtuin Activators and Inhibitors

    Antonello Mai;Sergio Valente;Sarah Meade;Vincenzo Carafa

  • epigenetic multiple ligands: mixed histone/protein methyltransferase, acetyltransferase, and class III deacetylase (sirtuin) inhibitors.

    Antonello Mai;Donghang Cheng;Mark T. Bedford;Sergio Valente

  • "Shock and kill" effects of class I-selective histone deacetylase inhibitors in combination with the glutathione synthesis inhibitor buthionine sulfoximine in cell line models for HIV-1 quiescence.

    Andrea Savarino;Antonello Mai;Sandro Norelli;Sary El Daker

  • Pan-histone demethylase inhibitors simultaneously targeting Jumonji C and lysine-specific demethylases display high anticancer activities

    Dante Rotili;Stefano Tomassi;Mariarosaria Conte;Rosaria Benedetti

  • Selective non-nucleoside inhibitors of human DNA methyltransferases active in cancer including in cancer stem cells.

    Sergio Valente;Yiwei Liu;Michael Schnekenburger;Clemens Zwergel

  • Nitric Oxide Modulates Chromatin Folding in Human Endothelial Cells via Protein Phosphatase 2A Activation and Class II Histone Deacetylases Nuclear Shuttling

    Barbara Illi;Claudio Dello Russo;Claudia Colussi;Jessica Rosati

  • Specific activity of class II histone deacetylases in human breast cancer cells.

    Vanessa Duong;Caroline Bret;Lucia Altucci;Antonello Mai

  • Epi-drugs in combination with immunotherapy: a new avenue to improve anticancer efficacy.

    Roberta Mazzone;Roberta Mazzone;Clemens Zwergel;Antonello Mai;Sergio Valente

  • 1,3,4-Oxadiazole-containing histone deacetylase inhibitors: anticancer activities in cancer cells.

    Sergio Valente;Daniela Trisciuoglio;Teresa De Luca;Angela Nebbioso

  • Aurones: interesting natural and synthetic compounds with emerging biological potential.

    Clemens Zwergel;François Gaascht;Sergio Valente;Marc Diederich

  • A Nitric Oxide-dependent Cross-talk between Class I and III Histone Deacetylases Accelerates Skin Repair

    Francesco Spallotta;Chiara Cencioni;Stefania Straino;Simona Nanni

  • Novel 3,5-bis(bromohydroxybenzylidene)piperidin-4-ones as coactivator-associated arginine methyltransferase 1 inhibitors: Enzyme selectivity and cellular activity

    Donghang Cheng;Sergio Valente;Sabrina Castellano;Gianluca Sbardella

  • in human breast cancer cells

    Vanessa Duong;Caroline Bret;Lucia Altucci;Antonello Mai

Frequent Co-Authors

Antonello Mai
Antonello Mai Sapienza University of Rome
Lucia Altucci
Lucia Altucci University of Campania "Luigi Vanvitelli"
Dante Rotili
Dante Rotili Sapienza University of Rome
Saverio Minucci
Saverio Minucci European Institute of Oncology
Andrea Mattevi
Andrea Mattevi University of Pavia
Gilbert Kirsch
Gilbert Kirsch University of Lorraine
Gerald Brosch
Gerald Brosch Innsbruck Medical University
Carlo Gaetano
Carlo Gaetano Goethe University Frankfurt
Marc Diederich
Marc Diederich Seoul National University
Ettore Novellino
Ettore Novellino University of Naples Federico II

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