What is she best known for?
The fields of study she is best known for:
Her primary areas of investigation include Cell biology, Neurotrophin, Signal transduction, Mitochondrion and Neurotrophic factors.
Her work deals with themes such as Internal medicine, Trk receptor and Programmed cell death, which intersect with Cell biology.
In her research on the topic of Internal medicine, Endocrinology, Cellular differentiation and Neural crest is strongly related with SH-SY5Y.
Her Programmed cell death study is concerned with the field of Apoptosis as a whole.
In her research, Neuroscience is intimately related to Brain-derived neurotrophic factor, which falls under the overarching field of Neurotrophin.
Her biological study spans a wide range of topics, including Unfolded protein response, Endoplasmic reticulum, Downregulation and upregulation and Nerve growth factor.
Her most cited work include:
- Sequential Treatment of SH‐SY5Y Cells with Retinoic Acid and Brain‐Derived Neurotrophic Factor Gives Rise to Fully Differentiated, Neurotrophic Factor‐Dependent, Human Neuron‐Like Cells (562 citations)
- Extracellular-regulated kinases and phosphatidylinositol 3-kinase are involved in brain-derived neurotrophic factor-mediated survival and neuritogenesis of the neuroblastoma cell line SH-SY5Y. (226 citations)
- Receptors of the glial cell line-derived neurotrophic factor family of neurotrophic factors signal cell survival through the phosphatidylinositol 3-kinase pathway in spinal cord motoneurons. (161 citations)
What are the main themes of her work throughout her whole career to date?
Her main research concerns Cell biology, Apoptosis, Programmed cell death, Molecular biology and Neuroscience.
Her studies deal with areas such as Neurotrophic factors, Trk receptor, Neurotrophin and Neurite as well as Cell biology.
As a part of the same scientific study, Joan X. Comella usually deals with the Neurotrophin, concentrating on Brain-derived neurotrophic factor and frequently concerns with Protein kinase B and SH-SY5Y.
Her research investigates the connection with Apoptosis and areas like Downregulation and upregulation which intersect with concerns in Heat shock protein, Caspase 12, XBP1, Unfolded protein response and Endoplasmic reticulum.
The various areas that Joan X. Comella examines in her Programmed cell death study include Cell, Cancer research, Flip and Mitochondrion.
Her Neuroscience study combines topics in areas such as Neuroinflammation and Intracellular.
She most often published in these fields:
- Cell biology (68.29%)
- Apoptosis (27.64%)
- Programmed cell death (26.02%)
What were the highlights of her more recent work (between 2012-2021)?
- Cell biology (68.29%)
- Apoptosis (27.64%)
- Neuroscience (21.14%)
In recent papers she was focusing on the following fields of study:
Joan X. Comella mainly focuses on Cell biology, Apoptosis, Neuroscience, Cancer research and Dendritic spine.
The Cell biology study combines topics in areas such as Inhibitor of apoptosis, XIAP, Neurite, Receptor and Gene isoform.
Her Apoptosis research incorporates elements of Immunology and Receptor antagonist.
Her studies in Neuroscience integrate themes in fields like Neuroinflammation, Knockout mouse, Neurodegeneration and Guanylate kinase.
Her research in Cancer research focuses on subjects like Downregulation and upregulation, which are connected to Kinase and Cellular differentiation.
Her Dendritic spine research integrates issues from Neurogenesis and Biophysics.
Between 2012 and 2021, her most popular works were:
- Oxidative stress and proinflammatory cytokines contribute to demyelination and axonal damage in a cerebellar culture model of neuroinflammation. (151 citations)
- Phagocytic clearance of presynaptic dystrophies by reactive astrocytes in Alzheimer's disease. (71 citations)
- Histone deacetylase inhibitors promote glioma cell death by G2 checkpoint abrogation leading to mitotic catastrophe (55 citations)
In her most recent research, the most cited papers focused on:
Her primary areas of study are Synaptogenesis, Neurogenesis, Dendritic spine, Neuroscience and Cell biology.
Joan X. Comella has included themes like Dentate gyrus, Hippocampal formation, Reelin, DAB1 and Intracellular in her Synaptogenesis study.
She combines topics linked to Biophysics with her work on Neurogenesis.
She connects Dendritic spine with Focused ion beam in her study.
Her Cell biology study incorporates themes from Cancer research, Transcription factor and Downregulation and upregulation.
The study incorporates disciplines such as Tumor Virus, Cancer, Molecular oncology and MAPK/ERK pathway in addition to Cancer research.
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