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Cesare Montecucco

Cesare Montecucco

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Biology and Biochemistry
Italy
2026

D-Index & Metrics

Biology and Biochemistry

D-Index
107
Citations
41579
World Ranking
1105
National Ranking
11

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in Italy Leader Award
  • 2025 - Research.com Biology and Biochemistry in Italy Leader Award
  • 2023 - Research.com Biology and Biochemistry in Italy Leader Award
  • 2022 - Research.com Biology and Biochemistry in Italy Leader Award

Overview

Cesare Montecucco is affiliated with the University of Padua in Italy. Their research spans multiple fields, primarily focusing on Medicine, Biochemistry, Genetics and Molecular Biology, and Neuroscience. Within these broader areas, they have contributed significantly to subfields including Neurology, Cellular and Molecular Neuroscience, Genetics, Endocrinology, and Molecular Biology.

The main topics of Cesare Montecucco's work include:

  • Botulinum Toxin and Related Neurological Disorders
  • Hereditary Neurological Disorders
  • Diphtheria, Corynebacterium, and Tetanus
  • Venomous Animal Envenomation and Studies
  • Neurological disorders and treatments
  • Marine Invertebrate Physiology and Ecology
  • Streptococcal Infections and Treatments

Their recent papers demonstrate a focus on neurotoxins and neurological physiology, with notable publications such as:

  • "Tetanus and tetanus neurotoxin: From peripheral uptake to central nervous tissue targets," 2021, Journal of Neurochemistry
  • "Botulinum Neurotoxins: Mechanism of Action," 2020, Handbook of Experimental Pharmacology
  • "Toxicology and pharmacology of botulinum and tetanus neurotoxins: an update," 2022, Archives of Toxicology
  • "Clinical duration of action of different botulinum toxin types in humans," 2020, Toxicon
  • "Melatonin promotes regeneration of injured motor axons via MT1 receptors," 2020, Journal of Pineal Research

Cesare Montecucco frequently collaborates with other researchers, with high counts of co-authorship alongside Ornella Rossetto, Marco Pirazzini, Aram Megighian, F Fabris, and Samuele Negro. This collaborative network reflects engagement in a range of experimental and clinical studies related to their fields of expertise.

Their work has been published in several key scientific venues, most notably:

  • Toxicon
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Neurochemistry
  • International Journal of Molecular Sciences
  • PLoS Neglected Tropical Diseases

Best Publications

  • Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin

    Giampietro G. Schiavo;Fabio Benfenati;Bernard Poulain;Ornella Rossetto

  • Neurotoxins Affecting Neuroexocytosis

    Giampietro Schiavo;Michela Matteoli;Cesare Montecucco

  • Gene structure of the Helicobacter pylori cytotoxin and evidence of its key role in gastric disease.

    J L Telford;P Ghiara;M Dell'Orco;M Comanducci

  • Botulinum Neurotoxins: Biology, Pharmacology, and Toxicology.

    Marco Pirazzini;Ornella Rossetto;Roberto Eleopra;Cesare Montecucco

  • Mechanism of action of tetanus and botulinum neurotoxins.

    Cesare Montecucco;Glampietro Schiavo

  • Anthrax lethal factor cleaves the N‐terminus of MAPKKS and induces tyrosine/threonine phosphorylation of MAPKS in cultured macrophages

    G. Vitale;R. Pellizzari;C. Recchi;G. Napolitani

  • Living dangerously: how Helicobacter pylori survives in the human stomach

    Cesare Montecucco;Rino Rappuoli

  • Botulinum neurotoxins: genetic, structural and mechanistic insights

    Ornella Rossetto;Marco Pirazzini;Cesare Montecucco

  • Structure and function of tetanus and botulinum neurotoxins

    Cesare Montecucco;Giampietro Schiavo

  • Identification of the nerve terminal targets of botulinum neurotoxin serotypes A, D, and E.

    G Schiavo;O Rossetto;S Catsicas;P Polverino de Laureto

  • Botulinum neurotoxins serotypes A and E cleave SNAP-25 at distinct COOH-terminal peptide bonds

    Giampietro Schiavo;Annalisa Santucci;Bibhuti R. Dasgupta;Prashant P. Mehta

  • How do tetanus and botulinum toxins bind to neuronal membranes

    Cesare Montecucco

  • The neutrophil-activating protein (HP-NAP) of Helicobacter pylori is a protective antigen and a major virulence factor.

    Barbara Satin;Giuseppe Del Giudice;Vittorina Della Bianca;Stefano Dusi

  • G-CSF-stimulated neutrophils are a prominent source of functional BLyS.

    Patrizia Scapini;Bernardetta Nardelli;Gianpaolo Nadali;Federica Calzetti

  • Susceptibility of mitogen-activated protein kinase kinase family members to proteolysis by anthrax lethal factor

    Gaetano Vitale;Lorenzo Bernardi;Giorgio Napolitani;Michèle Mock

  • The use of acetylated ferricytochrome c for the detection of superoxide radicals produced in biological membranes.

    Angelo Azzi;Cesare Montecucco;Christoph Richter

  • Botulinum neurotoxin serotype F is a zinc endopeptidase specific for VAMP/synaptobrevin

    G. Schiavo;C. C. Shone;O. Rossetto;F. C. G. Alexander

  • Botulinal neurotoxins: revival of an old killer.

    Cesare Montecucco;Jordi Molgó

  • Selective Inhibition of Ii-dependent Antigen Presentation by Helicobacter pylori Toxin VacA

    Maurizio Molinari;Mariolina Salio;Carmela Galli;Nathalie Norais

  • Anthrax lethal factor cleaves MKK3 in macrophages and inhibits the LPS/IFNγ‐induced release of NO and TNFα

    Rossella Pellizzari;Chantal Guidi-Rontani;Gaetano Vitale;Michèle Mock

Frequent Co-Authors

Ornella Rossetto
Ornella Rossetto University of Padua
Giampietro Schiavo
Giampietro Schiavo University College London
Emanuele Papini
Emanuele Papini University of Padua
Rino Rappuoli
Rino Rappuoli Imperial College London
Thomas Binz
Thomas Binz Hanover University of Applied Sciences and Arts
John L. Telford
John L. Telford GlaxoSmithKline (Italy)
Roberto Eleopra
Roberto Eleopra Misericordia University
Michèle Mock
Michèle Mock Institut Pasteur
Giuseppe Del Giudice
Giuseppe Del Giudice GlaxoSmithKline (United Kingdom)
Giuseppe Zanotti
Giuseppe Zanotti University of Padua

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