The scientist’s investigation covers issues in Bacillus anthracis, Anthrax toxin, Microbiology, Toxin and Molecular biology. His studies in Bacillus anthracis integrate themes in fields like Virulence factor, Antibody, Pathogenesis and Antigen. The concepts of his Anthrax toxin study are interwoven with issues in Protease, Receptor, Internalization, Endocytosis and Cell biology.
His research in Microbiology intersects with topics in Virology, Immunology, Immunity, Anthrax toxin receptor 2 and In vivo. His research integrates issues of Virulence, Edema and Cytotoxicity in his study of Toxin. His Molecular biology research is multidisciplinary, incorporating elements of Open reading frame, Mutant, Fusion protein and Signal peptide.
His primary areas of study are Bacillus anthracis, Anthrax toxin, Microbiology, Toxin and Molecular biology. His Bacillus anthracis study combines topics from a wide range of disciplines, such as Antibody, Monoclonal antibody, Antigen and Virology. His Anthrax toxin research is multidisciplinary, incorporating perspectives in Receptor, Protease, Fusion protein and In vivo.
His research investigates the link between Microbiology and topics such as Inflammasome that cross with problems in Programmed cell death and Innate immune system. His work deals with themes such as Immunology, Internalization, Pharmacology and Edema, which intersect with Toxin. Stephen H. Leppla interconnects Epitope, Cell, Pseudomonas exotoxin and Proteases in the investigation of issues within Molecular biology.
Bacillus anthracis, Anthrax toxin, Toxin, Microbiology and Cell biology are his primary areas of study. His Bacillus anthracis research includes elements of Plasmid, Virology, Cell division, Kinase and Virulence. He has researched Anthrax toxin in several fields, including Proteases, Molecular biology and Receptor, Endosome.
His Toxin research includes themes of Nitric oxide synthase, Edema, Lung, Pharmacology and In vivo. His study in Microbiology is interdisciplinary in nature, drawing from both Hemolysin and Permeability. His Cell biology study incorporates themes from Pyroptosis, Inflammasome, Cell growth and Tyrosine hydroxylase.
His main research concerns Bacillus anthracis, Anthrax toxin, Microbiology, Inflammasome and Pyroptosis. A large part of his Bacillus anthracis studies is devoted to Anthrax vaccines. His biological study spans a wide range of topics, including Epitope, Toxin, In vivo and Cytosol.
As part of his studies on Microbiology, he often connects relevant subjects like Virulence. The Inflammasome study which covers Cell biology that intersects with Cell cycle, Cancer cell and Cell migration. Many of his studies involve connections with topics such as Molecular biology and Biochemistry.
This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.
Anthrax toxin edema factor: a bacterial adenylate cyclase that increases cyclic AMP concentrations of eukaryotic cells.
S H Leppla.
Proceedings of the National Academy of Sciences of the United States of America (1982)
Proteolytic Inactivation of MAP-Kinase-Kinase by Anthrax Lethal Factor
Nicholas S. Duesbery;Craig P. Webb;Stephen H. Leppla;Valery M. Gordon.
Science (1998)
Crystal structure of the anthrax toxin protective antigen.
C Petosa;R.J Collier;K.R Klimpel;S.H Leppla.
Nature (1997)
Anthrax toxin protective antigen is activated by a cell surface protease with the sequence specificity and catalytic properties of furin
Kurt R. Klimpel;Sean S. Molloy;Gary Thomas;Stephen H. Leppla.
Proceedings of the National Academy of Sciences of the United States of America (1992)
Anthrax toxin triggers endocytosis of its receptor via a lipid raft–mediated clathrin-dependent process
Laurence Abrami;Shihui Liu;Pierre Cosson;Stephen H. Leppla.
Journal of Cell Biology (2003)
Crystal structure of the anthrax lethal factor
AD Pannifer;TY Wong;Robert Schwarzenbacher;M Renatus.
Nature (2001)
Rapid induction of inflammatory lipid mediators by the inflammasome in vivo
Jakob von Moltke;Norver J. Trinidad;Mahtab Moayeri;Alexander F. Kintzer.
Nature (2012)
Bacillus anthracis lethal toxin induces TNF-α–independent hypoxia-mediated toxicity in mice
Mahtab Moayeri;Diana Haines;Howard A. Young;Stephen H. Leppla.
Journal of Clinical Investigation (2003)
Anthrax toxin lethal factor contains a zinc metalloprotease consensus sequence which is required for lethal toxin activity.
Kurt R. Klimpel;Naveen Arora;Stephen H. Leppla.
Molecular Microbiology (1994)
Protection against anthrax toxin by recombinant antibody fragments correlates with antigen affinity.
Jennifer A. Maynard;Catharina B.M. Maassen;Stephen H. Leppla;Kathleen Brasky.
Nature Biotechnology (2002)
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