World's Best Scientists 2026 revealed!

D-Index & Metrics

Microbiology

D-Index
106
Citations
33844
World Ranking
305
National Ranking
138

Stephen H. Leppla publication distribution in Microbiology in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Microbiology in 2026. The highlighted bar marks where Stephen H. Leppla sits on this spectrum.

55–64 publications: 8 scientists 65–74 publications: 29 scientists 75–84 publications: 55 scientists 85–94 publications: 112 scientists 95–104 publications: 137 scientists 105–114 publications: 190 scientists 115–124 publications: 235 scientists 125–134 publications: 234 scientists 135–144 publications: 288 scientists 145–154 publications: 265 scientists 155–164 publications: 264 scientists 165–174 publications: 253 scientists 175–184 publications: 276 scientists 185–194 publications: 190 scientists 195–204 publications: 234 scientists 205–214 publications: 208 scientists 215–224 publications: 198 scientists 225–234 publications: 155 scientists 235–244 publications: 161 scientists 245–254 publications: 160 scientists 255–264 publications: 146 scientists 265–274 publications: 139 scientists 275–284 publications: 148 scientists 285–294 publications: 115 scientists 295–304 publications: 96 scientists 305–314 publications: 88 scientists 315–324 publications: 106 scientists 325–334 publications: 65 scientists 335–344 publications: 76 scientists 345–354 publications: 64 scientists 355–364 publications: 62 scientists 365–374 publications: 65 scientists 375–384 publications: 61 scientists 385–394 publications: 34 scientists 395–404 publications: 44 scientists 405–414 publications: 36 scientists 415–424 publications: 35 scientists 425–434 publications: 29 scientists 435–444 publications: 33 scientists 445–454 publications: 34 scientists 455–464 publications: 25 scientists 465–474 publications: 26 scientists 475–484 publications: 20 scientists 485–494 publications: 19 scientists 495–504 publications: 16 scientists 505–514 publications: 17 scientists 515–524 publications: 23 scientists 525–534 publications: 14 scientists 535–544 publications: 14 scientists 545–554 publications: 18 scientists 555–564 publications: 12 scientists 565–574 publications: 7 scientists 575–584 publications: 9 scientists 585–594 publications: 9 scientists 595–604 publications: 9 scientists 605–614 publications: 7 scientists 615–624 publications: 9 scientists 625–634 publications: 7 scientists 635–644 publications: 4 scientists 645–654 publications: 5 scientists 655–664 publications: 6 scientists 665–674 publications: 7 scientists 675–678 publications: 3 scientists 679+ publications: 99 scientists
55 publications 679+

This scientist: 355 publications — 85th percentile

85% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 679 publications or more.

Stephen H. Leppla D-index placement in Microbiology in 2026

The chart shows the D-index (discipline H-index) distribution of Microbiology scientists ranked by Research.com in 2026. The highlighted bar marks where Stephen H. Leppla sits on this spectrum.

40 D-Index: 30 scientists 41 D-Index: 86 scientists 42 D-Index: 90 scientists 43 D-Index: 117 scientists 44 D-Index: 122 scientists 45 D-Index: 123 scientists 46 D-Index: 108 scientists 47 D-Index: 110 scientists 48 D-Index: 106 scientists 49 D-Index: 109 scientists 50 D-Index: 129 scientists 51 D-Index: 111 scientists 52 D-Index: 116 scientists 53 D-Index: 127 scientists 54 D-Index: 134 scientists 55 D-Index: 134 scientists 56 D-Index: 112 scientists 57 D-Index: 136 scientists 58 D-Index: 162 scientists 59 D-Index: 151 scientists 60 D-Index: 139 scientists 61 D-Index: 123 scientists 62 D-Index: 126 scientists 63 D-Index: 144 scientists 64 D-Index: 109 scientists 65 D-Index: 103 scientists 66 D-Index: 124 scientists 67 D-Index: 112 scientists 68 D-Index: 103 scientists 69 D-Index: 131 scientists 70 D-Index: 94 scientists 71 D-Index: 93 scientists 72 D-Index: 96 scientists 73 D-Index: 92 scientists 74 D-Index: 80 scientists 75 D-Index: 66 scientists 76 D-Index: 87 scientists 77 D-Index: 60 scientists 78 D-Index: 73 scientists 79 D-Index: 59 scientists 80 D-Index: 57 scientists 81 D-Index: 55 scientists 82 D-Index: 47 scientists 83 D-Index: 77 scientists 84 D-Index: 50 scientists 85 D-Index: 45 scientists 86 D-Index: 42 scientists 87 D-Index: 41 scientists 88 D-Index: 32 scientists 89 D-Index: 38 scientists 90 D-Index: 35 scientists 91 D-Index: 34 scientists 92 D-Index: 27 scientists 93 D-Index: 26 scientists 94 D-Index: 33 scientists 95 D-Index: 22 scientists 96 D-Index: 37 scientists 97 D-Index: 22 scientists 98 D-Index: 21 scientists 99 D-Index: 22 scientists 100 D-Index: 30 scientists 101 D-Index: 16 scientists 102 D-Index: 20 scientists 103 D-Index: 17 scientists 104 D-Index: 19 scientists 105 D-Index: 16 scientists 106 D-Index: 19 scientists 107 D-Index: 18 scientists 108 D-Index: 14 scientists 109 D-Index: 10 scientists 110 D-Index: 9 scientists 111 D-Index: 7 scientists 112 D-Index: 11 scientists 113 D-Index: 6 scientists 114 D-Index: 15 scientists 115 D-Index: 10 scientists 116 D-Index: 12 scientists 117 D-Index: 7 scientists 118 D-Index: 10 scientists 119 D-Index: 10 scientists 120 D-Index: 11 scientists 121 D-Index: 2 scientists 122 D-Index: 7 scientists 123 D-Index: 12 scientists 124 D-Index: 5 scientists 125 D-Index: 9 scientists 126 D-Index: 6 scientists 127+ D-Index: 95 scientists
40 D-Index 127+

This scientist: 106 D-Index — 95th percentile

95% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 127 D-Index or more.

Overview

Stephen H. Leppla is affiliated with the National Institutes of Health in the United States. Their research primarily focuses on biochemistry, genetics, and molecular biology, with particular expertise in molecular biology, genetics, biotechnology, ecology, and immunology. The main topics of Leppla's work encompass Bacillus and Francisella bacterial research, bacterial genetics and biotechnology, microbial inactivation methods, bacteriophages and microbial interactions, cancer research and treatments, microbial infections and disease research, and Yersinia bacterium, plague, and ectoparasites research.

Stephen H. Leppla has published extensively, including recent papers such as:

  • Bacillus cereus non-haemolytic enterotoxin activates the NLRP3 inflammasome (2020, Nature Communications)
  • Structural basis of R-loop recognition by the S9.6 monoclonal antibody (2022, Nature Communications)
  • ERK and c-Myc signaling in host-derived tumor endothelial cells is essential for solid tumor growth (2022, Proceedings of the National Academy of Sciences)
  • Anthrax toxins regulate pain signaling and can deliver molecular cargoes into ANTXR2+ DRG sensory neurons (2021, Nature Neuroscience)
  • Sequential CRISPR-Based Screens Identify LITAF and CDIP1 as the Bacillus cereus Hemolysin BL Toxin Host Receptors (2020, Cell Host & Microbe)

Leppla frequently publishes in scientific venues including:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Toxins
  • Nature Communications
  • Proceedings of the National Academy of Sciences
  • Nature Microbiology

Their collaborative work involves coauthors such as:

  • Mahtab Moayeri
  • Ankur Bothra
  • Shihui Liu
  • Rasem Fattah
  • Thomas Bugge

Leppla's research contributions cover a broad range of microbial and molecular topics, contributing to the understanding of bacterial pathogens, their toxins, and the molecular mechanisms underlying microbial interactions and disease processes. Their work includes investigation into bacterial enterotoxins, tumor cell signaling pathways, and the delivery of molecular cargo into sensory neurons by anthrax toxins.

Best Publications

  • Anthrax toxin edema factor: a bacterial adenylate cyclase that increases cyclic AMP concentrations of eukaryotic cells.

    S H Leppla

  • Proteolytic Inactivation of MAP-Kinase-Kinase by Anthrax Lethal Factor

    Nicholas S. Duesbery;Craig P. Webb;Stephen H. Leppla;Valery M. Gordon

  • Crystal structure of the anthrax toxin protective antigen.

    C Petosa;R.J Collier;K.R Klimpel;S.H Leppla

  • Human furin is a calcium-dependent serine endoprotease that recognizes the sequence Arg-X-X-Arg and efficiently cleaves anthrax toxin protective antigen.

    S S Molloy;P A Bresnahan;S H Leppla;K R Klimpel

  • Anthrax toxin protective antigen is activated by a cell surface protease with the sequence specificity and catalytic properties of furin

    Kurt R. Klimpel;Sean S. Molloy;Gary Thomas;Stephen H. Leppla

  • Anthrax toxin triggers endocytosis of its receptor via a lipid raft–mediated clathrin-dependent process

    Laurence Abrami;Shihui Liu;Pierre Cosson;Stephen H. Leppla

  • Crystal structure of the anthrax lethal factor

    AD Pannifer;TY Wong;Robert Schwarzenbacher;M Renatus

  • Rapid induction of inflammatory lipid mediators by the inflammasome in vivo

    Jakob von Moltke;Norver J. Trinidad;Mahtab Moayeri;Alexander F. Kintzer

  • Bacillus anthracis lethal toxin induces TNF-α–independent hypoxia-mediated toxicity in mice

    Mahtab Moayeri;Diana Haines;Howard A. Young;Stephen H. Leppla

  • Anthrax toxin lethal factor contains a zinc metalloprotease consensus sequence which is required for lethal toxin activity.

    Kurt R. Klimpel;Naveen Arora;Stephen H. Leppla

  • Protection against anthrax toxin by recombinant antibody fragments correlates with antigen affinity.

    Jennifer A. Maynard;Catharina B.M. Maassen;Stephen H. Leppla;Kathleen Brasky

  • The roles of anthrax toxin in pathogenesis.

    Mahtab Moayeri;Stephen H Leppla

  • Impairment of dendritic cells and adaptive immunity by anthrax lethal toxin.

    Anshu Agrawal;Jai Lingappa;Stephen H. Leppla;Sudhanshu Agrawal

  • Crystal structure of a complex between anthrax toxin and its host cell receptor

    Eugenio Santelli;Laurie A. Bankston;Stephen H. Leppla;Robert C. Liddington

  • Anthrax lethal factor cleavage of Nlrp1 is required for activation of the inflammasome.

    Jonathan L. Levinsohn;Zachary L. Newman;Kristina A. Hellmich;Rasem Fattah

  • Cellular and systemic effects of anthrax lethal toxin and edema toxin.

    Mahtab Moayeri;Stephen H. Leppla

  • Inhibitors of receptor-mediated endocytosis block the entry of Bacillus anthracis adenylate cyclase toxin but not that of Bordetella pertussis adenylate cyclase toxin.

    V M Gordon;S H Leppla;E L Hewlett

  • Effects of anthrax toxin components on human neutrophils.

    J O'Brien;A Friedlander;T Dreier;J Ezzell

  • Plant-Based Vaccine: Mice Immunized with Chloroplast-Derived Anthrax Protective Antigen Survive Anthrax Lethal Toxin Challenge

    Vijay Koya;Mahtab Moayeri;Stephen H. Leppla;Henry Daniell

  • Membrane insertion of anthrax protective antigen and cytoplasmic delivery of lethal factor occur at different stages of the endocytic pathway

    Laurence Abrami;Margaret Lindsay;Robert G. Parton;Stephen H. Leppla

  • Dual Role for Inflammasome Sensors NLRP1 and NLRP3 in Murine Resistance to Toxoplasma gondii

    Gezahegn Gorfu;Kimberly Cirelli;Mariane Bandeira Melo;Katrin Mayer-Barber

  • Production and characterization of monoclonal antibodies to the protective antigen component of Bacillus anthracis toxin.

    Stephen F. Little;Stephen H. Leppla;Elsa Cora

Frequent Co-Authors

Mahtab Moayeri
Mahtab Moayeri National Institutes of Health
Thomas H. Bugge
Thomas H. Bugge National Institutes of Health
Arthur E. Frankel
Arthur E. Frankel Wake Forest University
Yogendra Singh
Yogendra Singh University of Delhi
Arthur M. Friedlander
Arthur M. Friedlander United States Army Medical Research Institute of Infectious Diseases
Robert H. Purcell
Robert H. Purcell National Institute of Allergy and Infectious Diseases
Wei-Jen Tang
Wei-Jen Tang University of Chicago
Rachel Schneerson
Rachel Schneerson National Institutes of Health
Joseph Shiloach
Joseph Shiloach National Institutes of Health
Robert C. Liddington
Robert C. Liddington Discovery Institute

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