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Microbiology

D-Index
106
Citations
33844
World Ranking
305
National Ranking
138

Overview

Stephen H. Leppla is affiliated with the National Institutes of Health in the United States. Their research primarily focuses on biochemistry, genetics, and molecular biology, with particular expertise in molecular biology, genetics, biotechnology, ecology, and immunology. The main topics of Leppla's work encompass Bacillus and Francisella bacterial research, bacterial genetics and biotechnology, microbial inactivation methods, bacteriophages and microbial interactions, cancer research and treatments, microbial infections and disease research, and Yersinia bacterium, plague, and ectoparasites research.

Stephen H. Leppla has published extensively, including recent papers such as:

  • Bacillus cereus non-haemolytic enterotoxin activates the NLRP3 inflammasome (2020, Nature Communications)
  • Structural basis of R-loop recognition by the S9.6 monoclonal antibody (2022, Nature Communications)
  • ERK and c-Myc signaling in host-derived tumor endothelial cells is essential for solid tumor growth (2022, Proceedings of the National Academy of Sciences)
  • Anthrax toxins regulate pain signaling and can deliver molecular cargoes into ANTXR2+ DRG sensory neurons (2021, Nature Neuroscience)
  • Sequential CRISPR-Based Screens Identify LITAF and CDIP1 as the Bacillus cereus Hemolysin BL Toxin Host Receptors (2020, Cell Host & Microbe)

Leppla frequently publishes in scientific venues including:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Toxins
  • Nature Communications
  • Proceedings of the National Academy of Sciences
  • Nature Microbiology

Their collaborative work involves coauthors such as:

  • Mahtab Moayeri
  • Ankur Bothra
  • Shihui Liu
  • Rasem Fattah
  • Thomas Bugge

Leppla's research contributions cover a broad range of microbial and molecular topics, contributing to the understanding of bacterial pathogens, their toxins, and the molecular mechanisms underlying microbial interactions and disease processes. Their work includes investigation into bacterial enterotoxins, tumor cell signaling pathways, and the delivery of molecular cargo into sensory neurons by anthrax toxins.

Best Publications

  • Anthrax toxin edema factor: a bacterial adenylate cyclase that increases cyclic AMP concentrations of eukaryotic cells.

    S H Leppla

  • Proteolytic Inactivation of MAP-Kinase-Kinase by Anthrax Lethal Factor

    Nicholas S. Duesbery;Craig P. Webb;Stephen H. Leppla;Valery M. Gordon

  • Crystal structure of the anthrax toxin protective antigen.

    C Petosa;R.J Collier;K.R Klimpel;S.H Leppla

  • Human furin is a calcium-dependent serine endoprotease that recognizes the sequence Arg-X-X-Arg and efficiently cleaves anthrax toxin protective antigen.

    S S Molloy;P A Bresnahan;S H Leppla;K R Klimpel

  • Anthrax toxin protective antigen is activated by a cell surface protease with the sequence specificity and catalytic properties of furin

    Kurt R. Klimpel;Sean S. Molloy;Gary Thomas;Stephen H. Leppla

  • Anthrax toxin triggers endocytosis of its receptor via a lipid raft–mediated clathrin-dependent process

    Laurence Abrami;Shihui Liu;Pierre Cosson;Stephen H. Leppla

  • Crystal structure of the anthrax lethal factor

    AD Pannifer;TY Wong;Robert Schwarzenbacher;M Renatus

  • Rapid induction of inflammatory lipid mediators by the inflammasome in vivo

    Jakob von Moltke;Norver J. Trinidad;Mahtab Moayeri;Alexander F. Kintzer

  • Bacillus anthracis lethal toxin induces TNF-α–independent hypoxia-mediated toxicity in mice

    Mahtab Moayeri;Diana Haines;Howard A. Young;Stephen H. Leppla

  • Anthrax toxin lethal factor contains a zinc metalloprotease consensus sequence which is required for lethal toxin activity.

    Kurt R. Klimpel;Naveen Arora;Stephen H. Leppla

  • Protection against anthrax toxin by recombinant antibody fragments correlates with antigen affinity.

    Jennifer A. Maynard;Catharina B.M. Maassen;Stephen H. Leppla;Kathleen Brasky

  • The roles of anthrax toxin in pathogenesis.

    Mahtab Moayeri;Stephen H Leppla

  • Impairment of dendritic cells and adaptive immunity by anthrax lethal toxin.

    Anshu Agrawal;Jai Lingappa;Stephen H. Leppla;Sudhanshu Agrawal

  • Crystal structure of a complex between anthrax toxin and its host cell receptor

    Eugenio Santelli;Laurie A. Bankston;Stephen H. Leppla;Robert C. Liddington

  • Anthrax lethal factor cleavage of Nlrp1 is required for activation of the inflammasome.

    Jonathan L. Levinsohn;Zachary L. Newman;Kristina A. Hellmich;Rasem Fattah

  • Cellular and systemic effects of anthrax lethal toxin and edema toxin.

    Mahtab Moayeri;Stephen H. Leppla

  • Inhibitors of receptor-mediated endocytosis block the entry of Bacillus anthracis adenylate cyclase toxin but not that of Bordetella pertussis adenylate cyclase toxin.

    V M Gordon;S H Leppla;E L Hewlett

  • Effects of anthrax toxin components on human neutrophils.

    J O'Brien;A Friedlander;T Dreier;J Ezzell

  • Plant-Based Vaccine: Mice Immunized with Chloroplast-Derived Anthrax Protective Antigen Survive Anthrax Lethal Toxin Challenge

    Vijay Koya;Mahtab Moayeri;Stephen H. Leppla;Henry Daniell

  • Membrane insertion of anthrax protective antigen and cytoplasmic delivery of lethal factor occur at different stages of the endocytic pathway

    Laurence Abrami;Margaret Lindsay;Robert G. Parton;Stephen H. Leppla

  • Dual Role for Inflammasome Sensors NLRP1 and NLRP3 in Murine Resistance to Toxoplasma gondii

    Gezahegn Gorfu;Kimberly Cirelli;Mariane Bandeira Melo;Katrin Mayer-Barber

  • Production and characterization of monoclonal antibodies to the protective antigen component of Bacillus anthracis toxin.

    Stephen F. Little;Stephen H. Leppla;Elsa Cora

Frequent Co-Authors

Mahtab Moayeri
Mahtab Moayeri National Institutes of Health
Thomas H. Bugge
Thomas H. Bugge National Institutes of Health
Arthur E. Frankel
Arthur E. Frankel Wake Forest University
Yogendra Singh
Yogendra Singh University of Delhi
Arthur M. Friedlander
Arthur M. Friedlander United States Army Medical Research Institute of Infectious Diseases
Robert H. Purcell
Robert H. Purcell National Institute of Allergy and Infectious Diseases
Wei-Jen Tang
Wei-Jen Tang University of Chicago
Rachel Schneerson
Rachel Schneerson National Institutes of Health
Joseph Shiloach
Joseph Shiloach National Institutes of Health
Robert C. Liddington
Robert C. Liddington Discovery Institute

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