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Molecular Biology

D-Index
55
Citations
27837
World Ranking
2237
National Ranking
1106

Overview

Chad A. Cowan is affiliated with Beth Israel Deaconess Medical Center in the United States. Their research primarily intersects the fields of Biochemistry, Genetics and Molecular Biology, with a substantial focus also on Medicine.

The scientist's subfields of study include Molecular Biology, Immunology, Genetics, Oncology, and Cancer Research. Their body of work covers diverse topics such as CAR-T cell therapy research, Immune Cell Function and Interaction, CRISPR and Genetic Engineering, Biochemical and Molecular Research, RNA modifications and cancer, T-cell and B-cell Immunology, and Genomic variations and chromosomal abnormalities.

Chad A. Cowan has contributed to several recent publications, encompassing various aspects of molecular and cellular biology as well as disease-related research:

  • Allele-specific open chromatin in human iPSC neurons elucidates functional disease variants, 2020, Science
  • Identification of a combination of transcription factors that synergistically increases endothelial cell barrier resistance, 2020, Scientific Reports
  • Inducers of the endothelial cell barrier identified through chemogenomic screening in genome-edited hPSC-endothelial cells, 2020, Proceedings of the National Academy of Sciences
  • Cell-specific transcriptional control of mitochondrial metabolism by TIF1γ drives erythropoiesis, 2021, Science
  • Mitoregulin Controls β-Oxidation in Human and Mouse Adipocytes, 2020, Stem Cell Reports

Their frequent co-authors include Curtis R. Warren, Steven A. Carr, Haojie Yu, Mary H.C. Florido, and G. Grant Welstead, each of whom has collaborated in multiple publications with Cowan.

Chad A. Cowan has published frequently in venues such as Science, Cell Stem Cell, bioRxiv (Cold Spring Harbor Laboratory), Blood, and Scientific Reports. These journals reflect an emphasis on molecular biology and related biomedical sciences.

Best Publications

  • Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA

    Luigi Warren;Philip D. Manos;Philip D. Manos;Tim Ahfeldt;Tim Ahfeldt;Yuin-Han Loh

  • Disease-Specific Induced Pluripotent Stem Cells

    In Hyun Park;Natasha Arora;Hongguang Huo;Nimet Maherali

  • Nuclear Reprogramming of Somatic Cells After Fusion with Human Embryonic Stem Cells

    Chad A. Cowan;Jocelyn Atienza;Douglas A. Melton;Kevin Eggan

  • From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus

    Kiran Musunuru;Kiran Musunuru;Kiran Musunuru;Alanna Strong;Maria Frank-Kamenetsky;Noemi E. Lee

  • Derivation of embryonic stem-cell lines from human blastocysts.

    Chad A. Cowan;Irinha Klimanskaya;Jill Mcmahon;Jocelyn Atienza

  • Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains

    Manching Ku;Richard P. Koche;Richard P. Koche;Richard P. Koche;Esther Rheinbay;Esther Rheinbay;Esther Rheinbay;Eric M. Mendenhall;Eric M. Mendenhall

  • Marked differences in differentiation propensity among human embryonic stem cell lines

    Kenji Osafune;Kenji Osafune;Leslie Caron;Malgorzata Borowiak;Malgorzata Borowiak;Rita J Martinez;Rita J Martinez

  • A high-efficiency system for the generation and study of human induced pluripotent stem cells.

    Nimet Maherali;Tim Ahfeldt;Tim Ahfeldt;Alessandra Rigamonti;Jochen Utikal

  • Enhanced Efficiency of Human Pluripotent Stem Cell Genome Editing through Replacing TALENs with CRISPRs

    Qiurong Ding;Stephanie Nicole Regan;Yulei Xia;Leoníe A. Oostrom

  • A TALEN Genome-Editing System for Generating Human Stem Cell-Based Disease Models

    Qiurong Ding;Youn-Kyoung Lee;Esperance Anne Kreek Schaefer;Derek Tilghman Peters

  • β-Aminoisobutyric Acid Induces Browning of White Fat and Hepatic β-Oxidation and Is Inversely Correlated with Cardiometabolic Risk Factors

    Lee D. Roberts;Pontus Boström;Pontus Boström;John F. O’Sullivan;Robert T. Schinzel

  • Genome-wide Chromatin State Transitions Associated with Developmental and Environmental Cues

    Jiang Zhu;Mazhar Adli;James Y. Zou;Griet Verstappen;Griet Verstappen

  • Low Incidence of Off-Target Mutations in Individual CRISPR-Cas9 and TALEN Targeted Human Stem Cell Clones Detected by Whole-Genome Sequencing

    Adrian Veres;Bridget S. Gosis;Qiurong Ding;Ryan Collins

  • Exome-wide association study of plasma lipids in > 300,000 individuals

    Dajiang J Liu;Gina M Peloso;Gina M Peloso;Haojie Yu;Adam S Butterworth;Adam S Butterworth

  • Generation of vascular endothelial and smooth muscle cells from human pluripotent stem cells

    Christoph Patsch;Ludivine Challet-Meylan;Eva C. Thoma;Eduard Urich

  • Efficient ablation of genes in human hematopoietic stem and effector cells using CRISPR/Cas9

    Pankaj Kumar Mandal;Pankaj Kumar Mandal;Leonardo Manuel Ramos Ferreira;Ryan Collins;Torsten B Meissner

  • Permanent Alteration of PCSK9 With In Vivo CRISPR-Cas9 Genome Editing

    Qiurong Ding;Alanna Strong;Kevin M. Patel;Sze-Ling Ng

  • A comparison of non-integrating reprogramming methods.

    Thorsten M. Schlaeger;Laurence Marie Daheron;Thomas R Brickler;Samuel Entwisle

  • The SH2/SH3 adaptor Grb4 transduces B-ephrin reverse signals

    Chad A. Cowan;Mark Henkemeyer

  • Crystal structure of an Eph receptor-ephrin complex.

    Juha-Pekka Himanen;Kanagalaghatta R. Rajashankar;Martin Lackmann;Chad A. Cowan

Frequent Co-Authors

Kiran Musunuru
Kiran Musunuru University of Pennsylvania
Alexander Meissner
Alexander Meissner Max Planck Institute for Molecular Genetics
Douglas A. Melton
Douglas A. Melton Harvard University
Sekar Kathiresan
Sekar Kathiresan Harvard University
Jubao Duan
Jubao Duan University of Chicago
Alan R. Sanders
Alan R. Sanders NorthShore University HealthSystem
Pablo V. Gejman
Pablo V. Gejman NorthShore University HealthSystem
Robert E. Gerszten
Robert E. Gerszten Beth Israel Deaconess Medical Center
Mark Henkemeyer
Mark Henkemeyer The University of Texas Southwestern Medical Center
Derrick J. Rossi
Derrick J. Rossi Harvard University

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