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Genetics

D-Index
80
Citations
37613
World Ranking
1554
National Ranking
725

Overview

Kiran Musunuru is affiliated with the University of Pennsylvania in the United States. Their research primarily spans the fields of biochemistry, genetics, and molecular biology, with a substantial focus also on medicine.

Their work covers several specialized subfields, including molecular biology, cardiology and cardiovascular medicine, genetics, public health, environmental and occupational health, and physiology. Key topics addressed in their research include CRISPR and genetic engineering, RNA regulation and disease, virus-based gene therapy research, innovation and socioeconomic development, RNA and protein synthesis mechanisms, viral infections and immunology research, and cardiomyopathy and myosin studies.

Musunuru has published extensively, with frequent contributions to venues such as bioRxiv (Cold Spring Harbor Laboratory), Circulation, Circulation Genomic and Precision Medicine, Nature Biomedical Engineering, and Arteriosclerosis Thrombosis and Vascular Biology.

Selected recent publications by Musunuru include:

  • In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primates, 2021, Nature
  • Genetic Testing for Inherited Cardiovascular Diseases: A Scientific Statement From the American Heart Association, 2020, Circulation Genomic and Precision Medicine

Their frequent collaborators include researchers such as Xiao Wang, David R. Liu, Ping Qü, and Mohamad-Gabriel Alameh, reflecting a network of coauthors involved in genetic and cardiovascular research.

Best Publications

  • Biological, clinical and population relevance of 95 loci for blood lipids

    Tanya M. Teslovich;Kiran Musunuru;Albert V. Smith;Andrew C. Edmondson

  • Plasma HDL cholesterol and risk of myocardial infarction: A mendelian randomisation study

    Benjamin F. Voight;Benjamin F. Voight;Benjamin F. Voight;Gina M. Peloso;Gina M. Peloso;Marju Orho-Melander;Ruth Frikke-Schmidt

  • Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease

    Heribert Schunkert;Inke R. König;Sekar Kathiresan;Muredach P. Reilly

  • Common variants at 30 loci contribute to polygenic dyslipidemia.

    Sekar Kathiresan;Sekar Kathiresan;Sekar Kathiresan;Cristen J. Willer;Gina M. Peloso;Serkalem Demissie

  • From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus

    Kiran Musunuru;Kiran Musunuru;Kiran Musunuru;Alanna Strong;Maria Frank-Kamenetsky;Noemi E. Lee

  • Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants.

    Sekar Kathiresan;Benjamin F Voight;Shaun Purcell;Kiran Musunuru

  • Circular non-coding RNA ANRIL modulates ribosomal RNA maturation and atherosclerosis in humans.

    Lesca M. Holdt;Anika Stahringer;Kristina Sass;Garwin Pichler

  • Exome sequencing, ANGPTL3 mutations, and familial combined hypolipidemia.

    Kiran Musunuru;James P. Pirruccello;James P. Pirruccello;James P. Pirruccello;Ron Do;Ron Do;Ron Do;Gina M. Peloso;Gina M. Peloso

  • Enhanced Efficiency of Human Pluripotent Stem Cell Genome Editing through Replacing TALENs with CRISPRs

    Qiurong Ding;Stephanie Nicole Regan;Yulei Xia;Leoníe A. Oostrom

  • Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids.

    Benjamin S. Freedman;Craig R. Brooks;Albert Q. Lam;Albert Q. Lam;Hongxia Fu

  • A TALEN Genome-Editing System for Generating Human Stem Cell-Based Disease Models

    Qiurong Ding;Youn-Kyoung Lee;Esperance Anne Kreek Schaefer;Derek Tilghman Peters

  • Low Incidence of Off-Target Mutations in Individual CRISPR-Cas9 and TALEN Targeted Human Stem Cell Clones Detected by Whole-Genome Sequencing

    Adrian Veres;Bridget S. Gosis;Qiurong Ding;Ryan Collins

  • Exome-wide association study of plasma lipids in > 300,000 individuals

    Dajiang J Liu;Gina M Peloso;Gina M Peloso;Haojie Yu;Adam S Butterworth;Adam S Butterworth

  • Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits: A Multi-Ethnic Meta-Analysis of 45,891 Individuals

    Z Dastani;Hivert M-F.;Hivert M-F.;N Timpson;Perry Jrb.;Perry Jrb.

  • A dual AAV system enables the Cas9-mediated correction of a metabolic liver disease in newborn mice

    Yang Yang;Lili Wang;Peter Bell;Deirdre McMenamin

  • Efficient ablation of genes in human hematopoietic stem and effector cells using CRISPR/Cas9

    Pankaj Kumar Mandal;Pankaj Kumar Mandal;Leonardo Manuel Ramos Ferreira;Ryan Collins;Torsten B Meissner

  • Expanding the genetic editing tool kit: ZFNs, TALENs, and CRISPR-Cas9.

    Rajat M. Gupta;Kiran Musunuru

  • Permanent Alteration of PCSK9 With In Vivo CRISPR-Cas9 Genome Editing

    Qiurong Ding;Alanna Strong;Kevin M. Patel;Sze-Ling Ng

  • Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

    Cristian Pattaro;Alexander Teumer;Mathias Gorski;Audrey Y. Chu

  • In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primates.

    Kiran Musunuru;Alexandra C. Chadwick;Taiji Mizoguchi;Sara P. Garcia

Frequent Co-Authors

Sekar Kathiresan
Sekar Kathiresan Harvard University
Daniel J. Rader
Daniel J. Rader University of Pennsylvania
Chad A. Cowan
Chad A. Cowan Beth Israel Deaconess Medical Center
Benjamin F. Voight
Benjamin F. Voight University of Pennsylvania
Unnur Thorsteinsdottir
Unnur Thorsteinsdottir deCODE Genetics (Iceland)
Kari Stefansson
Kari Stefansson deCODE Genetics (Iceland)
Christopher J. O'Donnell
Christopher J. O'Donnell Harvard Medical School
L. Adrienne Cupples
L. Adrienne Cupples Boston University
Anna F. Dominiczak
Anna F. Dominiczak University of Glasgow
Nilesh J. Samani
Nilesh J. Samani University of Leicester

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