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Biology and Biochemistry

D-Index
81
Citations
22230
World Ranking
3921
National Ranking
1937

Overview

Thomas H. Bugge is affiliated with the National Institutes of Health in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, as well as Medicine, with a particular focus on subfields including Molecular Biology, Genetics, Pulmonary and Respiratory Medicine, Periodontics, and Biotechnology.

Their body of work includes significant contributions to topics such as Bacillus and Francisella bacterial research, Ion Transport and Channel Regulation, Microbial Inactivation Methods, Oral microbiology and periodontitis research, Cell Adhesion Molecules Research, Protease and Inhibitor Mechanisms, and Peptidase Inhibition and Analysis.

Frequent coauthors collaborating with Thomas H. Bugge include:

  • Lakmali M. Silva
  • Roman Szabo
  • Stephen H. Leppla
  • Niki M. Moutsopoulos
  • Matthew J. Flick

Their publications appear in several journals, with multiple articles in venues such as Toxins, Journal of Biological Chemistry, and bioRxiv (Cold Spring Harbor Laboratory). Other notable publication venues include Science and The Journal of Experimental Medicine.

Representative recent papers authored or co-authored by Thomas H. Bugge include:

  • "Fibrin is a critical regulator of neutrophil effector function at the oral mucosal barrier" (2021, Science)
  • "Neutrophil extracellular traps and extracellular histones potentiate IL-17 inflammation in periodontitis" (2023, The Journal of Experimental Medicine)
  • "ERK and c-Myc signaling in host-derived tumor endothelial cells is essential for solid tumor growth" (2022, Proceedings of the National Academy of Sciences)
  • "Cellular uptake of collagens and implications for immune cell regulation in disease" (2020, Cellular and Molecular Life Sciences)
  • "Membrane-anchored serine proteases as regulators of epithelial function" (2020, Biochemical Society Transactions)

Best Publications

  • Impaired wound healing in mice with a disrupted plasminogen gene.

    J Romer;T H Bugge;T H Bugge;C Pyke;L R Lund

  • Tissue-type plasminogen activator induces opening of the blood-brain barrier via the LDL receptor-related protein.

    Manuel Yepes;Maria Sandkvist;Elizabeth G. Moore;Thomas H. Bugge

  • Type II transmembrane serine proteases.

    Thomas H. Bugge;Toni M. Antalis;Qingyu Wu

  • An Extracellular Proteolytic Cascade Promotes Neuronal Degeneration in the Mouse Hippocampus

    Stella E. Tsirka;Andrew D. Rogove;Thomas H. Bugge;Jay L. Degen

  • Fatal embryonic bleeding events in mice lacking tissue factor, the cell-associated initiator of blood coagulation

    Thomas H. Bugge;Qing Xiao;Keith W. Kombrinck;Matthew J. Flick

  • Endothelial infection with KSHV genes in vivo reveals that vGPCR initiates Kaposi's sarcomagenesis and can promote the tumorigenic potential of viral latent genes

    Silvia Montaner;Akrit Sodhi;Akrit Sodhi;Alfredo Molinolo;Thomas H Bugge

  • Matriptase/MT-SP1 is required for postnatal survival, epidermal barrier function, hair follicle development, and thymic homeostasis.

    Karin List;Christian C Haudenschild;Roman Szabo;WanJun Chen

  • Urokinase-type plasminogen activator is effective in fibrin clearance in the absence of its receptor or tissue-type plasminogen activator.

    Thomas H. Bugge;Matthew J. Flick;Mary Jo S. Danton;Cynthia C. Daugherty

  • Membrane anchored serine proteases: a rapidly expanding group of cell surface proteolytic enzymes with potential roles in cancer.

    Sarah Netzel-Arnett;John D. Hooper;Roman Szabo;Edwin L. Madison

  • M2-like macrophages are responsible for collagen degradation through a mannose receptor–mediated pathway

    Daniel H. Madsen;Daniel Leonard;Andrius Masedunskas;Amanda Moyer

  • Functional overlap between two classes of matrix‐degrading proteases in wound healing

    Leif R. Lund;John Rømer;Thomas H. Bugge;Boye S. Nielsen

  • Prothrombin deficiency results in embryonic and neonatal lethality in mice

    William Y. Sun;David P. Witte;Jay L. Degen;Melissa C. Colbert

  • Deregulated matriptase causes ras-independent multistage carcinogenesis and promotes ras-mediated malignant transformation

    Karin List;Roman Szabo;Alfredo Molinolo;Virote Sriuranpong

  • Loss of proteolytically processed filaggrin caused by epidermal deletion of Matriptase/MT-SP1

    Karin List;Karin List;Roman Szabo;Philip W. Wertz;Julie Segre

  • Proteolytic Activation of the 1918 Influenza Virus Hemagglutinin

    Chawaree Chaipan;Darwyn Kobasa;Darwyn Kobasa;Stephanie Bertram;Ilona Glowacka

  • Type II transmembrane serine proteases.

    Roman Szabo;Qingyu Wu;Robert B. Dickson;Sarah Netzel-Arnett

  • Evidence for a Matriptase-Prostasin Proteolytic Cascade Regulating Terminal Epidermal Differentiation

    Sarah Netzel-Arnett;Brooke M. Currie;Roman Szabo;Chen Yong Lin

  • Type II transmembrane serine proteases in development and disease.

    Roman Szabo;Thomas H. Bugge

  • Targeting of tumor cells by cell surface urokinase plasminogen activator-dependent anthrax toxin

    Shihui Liu;Thomas H. Bugge;Stephen H. Leppla

  • MT1-MMP controls tumor-induced angiogenesis through the release of semaphorin 4D.

    John R. Basile;Kenn Holmbeck;Thomas H. Bugge;J. Silvio Gutkind

Frequent Co-Authors

Stephen H. Leppla
Stephen H. Leppla National Institutes of Health
Niels Behrendt
Niels Behrendt Technical University of Denmark
Alfredo A. Molinolo
Alfredo A. Molinolo University of California, San Diego
Jay L. Degen
Jay L. Degen Cincinnati Children's Hospital Medical Center
J. Silvio Gutkind
J. Silvio Gutkind University of California, San Diego
Keld Danø
Keld Danø Copenhagen University Hospital
Arthur E. Frankel
Arthur E. Frankel Wake Forest University
Daniel A. Lawrence
Daniel A. Lawrence University of Michigan–Ann Arbor
Boye Schnack Nielsen
Boye Schnack Nielsen Bioneer (Denmark)
David P. Witte
David P. Witte Cincinnati Children's Hospital Medical Center

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