World's Best Scientists 2026 revealed!

D-Index & Metrics

Medicine

D-Index
77
Citations
24700
World Ranking
18346
National Ranking
9157

Overview

Jay L. Degen is affiliated with Cincinnati Children's Hospital Medical Center in the United States. Their research primarily falls within the field of Medicine, with a focus on Infectious Diseases, Public Health, Environmental and Occupational Health, Clinical Biochemistry, Pulmonary and Respiratory Medicine, and Physiology.

The scientist's recent publications demonstrate an emphasis on bacterial infections and blood-related physiological processes. Key recent papers include:

  • Host fibrinogen drives antimicrobial function in Staphylococcus aureus peritonitis through bacterial-mediated prothrombin activation, 2020, Proceedings of the National Academy of Sciences
  • Fibrin(ogen) engagement of S. aureus promotes the host antimicrobial response and suppression of microbe dissemination following peritoneal infection, 2022, PLoS Pathogens
  • Factor XIII activity mediates red blood cell retention in venous thrombi, 2020, UNC Libraries

Degen's core research topics include:

  • Streptococcal Infections and Treatments
  • Clostridium difficile and Clostridium perfringens research
  • Antimicrobial Resistance in Staphylococcus
  • Bacterial Identification and Susceptibility Testing
  • Blood properties and coagulation
  • Erythrocyte Function and Pathophysiology
  • Erythropoietin and Anemia Treatment

Frequent co-authors collaborating with Degen include:

  • Matthew J. Flick
  • Joni M. Prasad
  • Oscar Negrón
  • Magnus Höök
  • Nigel Mackman

Degen's work has been published in several venues, with multiple publications appearing in:

  • Proceedings of the National Academy of Sciences
  • PLoS Pathogens
  • UNC Libraries

Their research addresses antimicrobial response mechanisms, microbial dissemination control, and blood coagulation factors. The scientist's investigations include the interactions between host proteins such as fibrinogen and pathogens like Staphylococcus aureus, as well as the physiological retention of red blood cells during thrombosis.

Best Publications

  • Physiological consequences of loss of plasminogen activator gene function in mice.

    Peter Carmeliet;Peter Carmeliet;Luc Schoonjans;Lena Kieckens;Beverly Ream

  • Replacement of diseased mouse liver by hepatic cell transplantation

    Jonathan A. Rhim;Eric P. Sandgren;Jay L. Degen;Richard D. Palmiter

  • Impaired wound healing in mice with a disrupted plasminogen gene.

    J Romer;T H Bugge;T H Bugge;C Pyke;L R Lund

  • Fibrinogen is an important determinant of the metastatic potential of circulating tumor cells.

    Joseph S. Palumbo;Keith W. Kombrinck;Angela F. Drew;Timothy S. Grimes

  • Plasminogen deficiency causes severe thrombosis but is compatible with development and reproduction.

    T H Bugge;M J Flick;C C Daugherty;J L Degen

  • Persistence of platelet thrombus formation in arterioles of mice lacking both von Willebrand factor and fibrinogen

    Heyu Ni;Cécile V. Denis;Sangeetha Subbarao;Jay L. Degen

  • Leukocyte engagement of fibrin(ogen) via the integrin receptor αMβ2/Mac-1 is critical for host inflammatory response in vivo

    Matthew J. Flick;Xin Li Du;David P. Witte;Markéta Jiroušková

  • Complete hepatic regeneration after somatic deletion of an albumin-plasminogen activator transgene.

    Eric P. Sandgren;Richard D. Palmiter;Janice L. Heckel;Cynthia C. Daugherty

  • Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation

    Dimitrios Davalos;Jae Kyu Ryu;Mario Merlini;Kim M. Baeten

  • Loss of Fibrinogen Rescues Mice from the Pleiotropic Effects of Plasminogen Deficiency

    Thomas H Bugge;Keith W Kombrinck;Matthew J Flick;Cynthia C Daugherty

  • An Extracellular Proteolytic Cascade Promotes Neuronal Degeneration in the Mouse Hippocampus

    Stella E. Tsirka;Andrew D. Rogove;Thomas H. Bugge;Jay L. Degen

  • Resolution of spontaneous bleeding events but failure of pregnancy in fibrinogen-deficient mice.

    T. T. Suh;K. Holmback;N. J. Jensen;C. C. Daugherty

  • Cerebral ischemia-hypoxia induces intravascular coagulation and autophagy.

    Faisal Adhami;Faisal Adhami;Guanghong Liao;Yury M. Morozov;Aryn Schloemer

  • Fatal embryonic bleeding events in mice lacking tissue factor, the cell-associated initiator of blood coagulation

    Thomas H. Bugge;Qing Xiao;Keith W. Kombrinck;Matthew J. Flick

  • Plasminogen Is Required for Efficient Dissemination of B. burgdorferi in Ticks and for Enhancement of Spirochetemia in Mice

    James L Coleman;Joseph A Gebbia;Joseph Piesman;Jay L Degen

  • Fibrinogen Triggers Astrocyte Scar Formation by Promoting the Availability of Active TGF-β after Vascular Damage

    Christian Schachtrup;Jae K. Ryu;Matthew J. Helmrick;Eirini Vagena

  • The fibrin-derived γ377-395 peptide inhibits microglia activation and suppresses relapsing paralysis in central nervous system autoimmune disease

    Ryan A. Adams;Jan S. Bauer;Matthew J. Flick;Shoana L. Sikorski

  • Tumor cell-associated tissue factor and circulating hemostatic factors cooperate to increase metastatic potential through natural killer cell-dependent and-independent mechanisms.

    Joseph S. Palumbo;Kathryn E. Talmage;Jessica V. Massari;Christine M. La Jeunesse

  • Urokinase-type plasminogen activator is effective in fibrin clearance in the absence of its receptor or tissue-type plasminogen activator.

    Thomas H. Bugge;Matthew J. Flick;Mary Jo S. Danton;Cynthia C. Daugherty

  • Functional overlap between two classes of matrix‐degrading proteases in wound healing

    Leif R. Lund;John Rømer;Thomas H. Bugge;Boye S. Nielsen

Frequent Co-Authors

David P. Witte
David P. Witte Cincinnati Children's Hospital Medical Center
Thomas H. Bugge
Thomas H. Bugge National Institutes of Health
Katerina Akassoglou
Katerina Akassoglou University of California, San Francisco
Keld Danø
Keld Danø Copenhagen University Hospital
Denisa D. Wagner
Denisa D. Wagner Boston Children's Hospital
David R. Morris
David R. Morris University of Washington
Jae K. Ryu
Jae K. Ryu Gladstone Institutes
Leif R. Lund
Leif R. Lund University of Copenhagen
Charles T. Esmon
Charles T. Esmon Oklahoma Medical Research Foundation
Hans Lassmann
Hans Lassmann Medical University of Vienna

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Interested in alternative or complementary medical career pathways? Numerous online degree programs now cater to students seeking flexible education in the healthcare field. For nursing professionals, exploring bsn to np programs online offers a streamlined path toward becoming a nurse practitioner, particularly in high-demand specializations like psychiatric mental health.

Those aiming for leadership or administrative roles may benefit from online healthcare administration programs, which teach essential skills for managing healthcare organizations. If cost is a concern, consider the cheapest mha online programs for a budget-friendly master's degree in healthcare administration.

For nurses pursuing advanced clinical practice, the best online bsn to dnp programs can help you attain a Doctor of Nursing Practice (DNP) efficiently and affordably. These options ensure that students and professionals can advance their careers without sacrificing work or family commitments.

Best Scientists Citing Jay L. Degen

Trending Scientists

Recently Published Articles