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Biology and Biochemistry

D-Index
75
Citations
17875
World Ranking
5387
National Ranking
2553

Overview

Daniel A. Lawrence is affiliated with the University of Michigan-Ann Arbor in the United States. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with notable contributions in subfields such as Neurology, Epidemiology, Cancer Research, Molecular Biology, and Hematology.

The scientist has explored a range of topics in their work, including:

  • Protease and Inhibitor Mechanisms
  • Acute Ischemic Stroke Management
  • Blood Coagulation and Thrombosis Mechanisms
  • Venous Thromboembolism Diagnosis and Management
  • Parkinson's Disease Mechanisms and Treatments
  • COVID-19 Clinical Research Studies
  • S100 Proteins and Annexins

Several recent publications illustrate the scope and focus of their research. Notable papers include:

  • Plasma tissue plasminogen activator and plasminogen activator inhibitor-1 in hospitalized COVID-19 patients, 2021, Scientific Reports
  • Drug Targeting of Plasminogen Activator Inhibitor-1 Inhibits Metabolic Dysfunction and Atherosclerosis in a Murine Model of Metabolic Syndrome, 2020, Arteriosclerosis Thrombosis and Vascular Biology
  • A high-fat diet delays plasmin generation in a thrombomodulin-dependent manner in mice, 2020, Blood
  • Compartmentalized Actions of the Plasminogen Activator Inhibitors, PAI-1 and Nsp, in Ischemic Stroke, 2022, Translational Stroke Research
  • Plasma tissue plasminogen activator and plasminogen activator inhibitor-1 in hospitalized COVID-19 patients, 2020, bioRxiv (Cold Spring Harbor Laboratory)

Frequent collaboration partners in their work include Enming J. Su, Mark Warnock, Daniel Torrente, Linda Fredriksson, and Kris Mann. These collaborations often span multiple studies and publications.

Their research is disseminated through key scientific venues such as bioRxiv (Cold Spring Harbor Laboratory), Blood, Journal of Biological Chemistry, Scientific Reports, and Arteriosclerosis Thrombosis and Vascular Biology. The largest number of publications appear in bioRxiv, followed by Blood and the Journal of Biological Chemistry.

Best Publications

  • The serpin PAI-1 inhibits cell migration by blocking integrin alpha V beta 3 binding to vitronectin.

    Steingrimur Stefansson;Daniel A. Lawrence

  • Tissue-type plasminogen activator induces opening of the blood-brain barrier via the LDL receptor-related protein.

    Manuel Yepes;Maria Sandkvist;Elizabeth G. Moore;Thomas H. Bugge

  • Purification of an inhibitor of plasminogen activator (antiactivator) synthesized by endothelial cells.

    J A van Mourik;D A Lawrence;D J Loskutoff

  • Detection of an unusually stable fibrinolytic inhibitor produced by bovine endothelial cells.

    D J Loskutoff;J A van Mourik;L A Erickson;D Lawrence

  • Cloning and sequence of a cDNA coding for the human beta-migrating endothelial-cell-type plasminogen activator inhibitor.

    Tor Ny;M Sawdey;D Lawrence;J L Millan

  • Activation of PDGF-CC by tissue plasminogen activator impairs blood-brain barrier integrity during ischemic stroke

    Enming J Su;Linda Fredriksson;Melissa Geyer;Erika Folestad

  • Familial dementia caused by polymerization of mutant neuroserpin

    Richard L. Davis;Antony E. Shrimpton;Peter D. Holohan;Charles Bradshaw

  • Neuroserpin reduces cerebral infarct volume and protects neurons from ischemia-induced apoptosis.

    Manuel Yepes;Maria Sandkvist;Maria Sandkvist;Maria Sandkvist;Mike K.K. Wong;Timothy A. Coleman;Timothy A. Coleman;Timothy A. Coleman

  • Platelet-derived Growth Factor (PDGF)-induced Tyrosine Phosphorylation of the Low Density Lipoprotein Receptor-related Protein (LRP) EVIDENCE FOR INTEGRATED CO-RECEPTOR FUNCTION BETWEEN LRP AND THE PDGF

    Elena Loukinova;Sripriya Ranganathan;Sergey Kuznetsov;Natalia Gorlatova

  • Plasminogen activator inhibitor-1 regulates tumor growth and angiogenesis.

    Grainne A. McMahon;Eric Petitclerc;Steingrimur Stefansson;Elizabeth Smith

  • Activated protein C stimulates the fibrinolytic activity of cultured endothelial cells and decreases antiactivator activity

    Yoichi Sakata;Scott Curriden;Dan Lawrence;John H. Griffin

  • Serpin-Protease Complexes Are Trapped as Stable Acyl-Enzyme Intermediates

    Daniel A. Lawrence;David Ginsburg;Duane E. Day;Mitchell B. Berkenpas

  • Neuroserpin, a Brain-associated Inhibitor of Tissue Plasminogen Activator Is Localized Primarily in Neurons IMPLICATIONS FOR THE REGULATION OF MOTOR LEARNING AND NEURONAL SURVIVAL

    Gregg A. Hastings;Timothy A. Coleman;Christian C. Haudenschild;Steingrimur Stefansson

  • Molecular evolution of plasminogen activator inhibitor-1 functional stability.

    M.B. Berkenpas;D.A. Lawrence;D. Ginsburg

  • The apoE isoform binding properties of the VLDL receptor reveal marked differences from LRP and the LDL receptor

    Jose Ruiz;Diana Kouiavskaia;Molly Migliorini;Susan Robinson

  • Inhibition of angiogenesis in vivo by plasminogen activator inhibitor-1.

    Steingrimur Stefansson;Eric Petitclerc;Michael Ka Keu Wong;Grainne A. McMahon

  • The Urokinase Receptor Is Expressed in Invasive Breast Cancer but not in Normal Breast Tissue

    E. Bianchi;R. L. Cohen;A. T. Thor;R. F. Todd

  • Endocytic receptor LRP together with tPA and PAI-1 coordinates Mac-1-dependent macrophage migration

    Chunzhang Cao;Daniel A Lawrence;Yang Li;Christine A F Von Arnim

  • The active conformation of plasminogen activator inhibitor 1, a target for drugs to control fibrinolysis and cell adhesion.

    Allan M Sharp;Penelope E Stein;Navraj S Pannu;Robin W Carrell

  • Plasminogen Activator Inhibitor-1 in Tumor Growth, Angiogenesis and Vascular Remodeling

    Steingrimur Stefansson;Grainne A. McMahon;Eric Petitclerc;Daniel A. Lawrence

Frequent Co-Authors

David Ginsburg
David Ginsburg University of Michigan–Ann Arbor
Dudley K. Strickland
Dudley K. Strickland American Red Cross
Tor Ny
Tor Ny Umeå University
David J. Loskutoff
David J. Loskutoff Scripps Research Institute
Robert L. Medcalf
Robert L. Medcalf Monash University
Ulf Eriksson
Ulf Eriksson AstraZeneca (United Kingdom)
Thomas H. Bugge
Thomas H. Bugge National Institutes of Health
David J. Pinsky
David J. Pinsky University of Michigan–Ann Arbor
Wayne A. Border
Wayne A. Border University of Utah
Geoffrey G. Murphy
Geoffrey G. Murphy University of Michigan–Ann Arbor

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