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D-Index & Metrics

Biology and Biochemistry

D-Index
58
Citations
12952
World Ranking
13110
National Ranking
5589

Overview

Paul J. Higgins is affiliated with Albany Medical Center Hospital in the United States and has contributed extensively to research primarily in the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Their work spans several subfields including Nephrology, Molecular Biology, Pulmonary and Respiratory Medicine, Cancer Research, and Oncology.

The scientist's recent publications cover key topics related to renal pathology, cancer mechanisms, and cellular signaling. Notable papers include:

  • Negative regulators of TGF-β1 signaling in renal fibrosis; pathological mechanisms and novel therapeutic opportunities, 2021, Clinical Science
  • Cancer-Associated Fibroblasts: Mechanisms of Tumor Progression and Novel Therapeutic Targets, 2022, Cancers
  • Downstream Targets of VHL/HIF-α Signaling in Renal Clear Cell Carcinoma Progression: Mechanisms and Therapeutic Relevance, 2023, Cancers
  • Emerging role of tumor suppressor p53 in acute and chronic kidney diseases, 2022, Cellular and Molecular Life Sciences
  • PAI-1 induction during kidney injury promotes fibrotic epithelial dysfunction via deregulation of klotho, p53, and TGF-β1-receptor signaling, 2021, The FASEB Journal

Frequently collaborated co-authors include:

  • Rohan Samarakoon
  • Cody C. Gifford
  • Jiaqi Tang
  • Angelica Costello
  • Roel Goldschmeding

Paul J. Higgins has published several articles in these prominent venues:

  • Cancers
  • The Journal of Urology
  • Cells
  • Frontiers in Cell and Developmental Biology
  • Journal of the American Society of Nephrology

The central themes of their research work focus on:

  • Chronic Kidney Disease and Diabetes
  • Renal and related cancers
  • Connective Tissue Growth Factor Research
  • Parathyroid Disorders and Treatments
  • Cancer Cells and Metastasis
  • Cancer, Hypoxia, and Metabolism
  • Renal cell carcinoma treatment

Paul J. Higgins's contributions reflect a multidisciplinary approach that bridges molecular and clinical aspects in nephrology and oncology contexts. Their research efforts provide insights into cellular pathways, signaling mechanisms, and potential therapeutic targets relevant for kidney diseases and cancer biology.

Best Publications

  • Control selection for RNA quantitation.

    Toshihide Suzuki;Paul J. Higgins;Dana R. Crawford

  • Reaction of monosaccharides with proteins: possible evolutionary significance.

    HF Bunn;PJ Higgins

  • Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence

    Roderik M. Kortlever;Paul J. Higgins;René Bernards

  • Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein and its fragments.

    P J Higgins;H L Weiner

  • Kinetic analysis of the nonenzymatic glycosylation of hemoglobin

    P J Higgins;H F Bunn

  • Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein. II. Suppression of disease and in vitro immune responses is mediated by antigen-specific CD8+ T lymphocytes.

    O. Lider;L. M. B. Santos;C. S. Y. Lee;P. J. Higgins

  • TGF-β signaling in tissue fibrosis: redox controls, target genes and therapeutic opportunities.

    Rohan Samarakoon;Jessica M. Overstreet;Paul J. Higgins

  • Histogenesis of benign pleomorphic adenoma (mixed tumor) of the major salivary glands. An ultrastructural and immunohistochemical study.

    Robert A. Erlandson;Carlos Cardon-Cardo;Paul J. Higgins

  • Translational Medicine definition by the European Society for Translational Medicine

    Randall J. Cohrs;Tyler Martin;Parviz Ghahramani;Luc Bidaut

  • PAI-1: An Integrator of Cell Signaling and Migration

    Ralf-Peter Czekay;Cynthia E. Wilkins-Port;Stephen P. Higgins;Jennifer Freytag

  • TGF-β1 → SMAD/p53/USF2 → PAI-1 transcriptional axis in ureteral obstruction-induced renal fibrosis

    Rohan Samarakoon;Jessica M. Overstreet;Stephen P. Higgins;Paul J. Higgins

  • Flow cytometric analysis of mouse spermatogenic function following exposure to ethylnitrosourea.

    Donald P. Evenson;Donald P. Evenson;Paul J. Higgins;Dorre Grueneberg;Brenda E. Ballachey

  • TGF-β1-induced PAI-1 gene expression requires MEK activity and cell-to-substrate adhesion

    Stacie M. Kutz;John Hordines;Paula J. McKeown-Longo;Paul J. Higgins

  • TNF-alpha induces peroxynitrite-mediated depletion of lung endothelial glutathione via protein kinase C

    D. T. Phelps;T. J. Ferro;P. J. Higgins;R. Shankar

  • Induction of renal fibrotic genes by TGF-β1 requires EGFR activation, p53 and reactive oxygen species.

    Rohan Samarakoon;Amy D. Dobberfuhl;Catherine Cooley;Jessica M. Overstreet

  • Glycosylated Hemoglobin in Human and Animal Red Cells: Role of Glucose Permeability

    P. J. Higgins;R. L. Garlick;H. F. Bunn

  • Integration of non-SMAD and SMAD signaling in TGF-β1-induced plasminogen activator inhibitor type-1 gene expression in vascular smooth muscle cells

    Rohan Samarakoon;Paul J. Higgins

  • Drugging the undruggable: transcription therapy for cancer.

    Chunhong Yan;Paul J. Higgins

  • TGF-β1/p53 signaling in renal fibrogenesis.

    Stephen P. Higgins;Yi Tang;Craig E. Higgins;Badar Mian

  • Characterization of glycosylated hemoglobins. Relevance to monitoring of diabetic control and analysis of other proteins.

    R L Garlick;J S Mazer;P J Higgins;H F Bunn

Frequent Co-Authors

Roel Goldschmeding
Roel Goldschmeding Utrecht University
Howard L. Weiner
Howard L. Weiner Harvard University
Maria B. Grant
Maria B. Grant University of Alabama at Birmingham
Terry J. Smith
Terry J. Smith University of Michigan–Ann Arbor
H F Bunn
H F Bunn Harvard Medical School
Michael E. Boulton
Michael E. Boulton University of Alabama at Birmingham
Donald P. Evenson
Donald P. Evenson University of South Dakota
Samia J. Khoury
Samia J. Khoury American University of Beirut
Raymond A. Sobel
Raymond A. Sobel Stanford University
Hendrik Luesch
Hendrik Luesch University of Florida

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