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Biology and Biochemistry

D-Index
79
Citations
31986
World Ranking
4219
National Ranking
2063

Research.com Recognitions

  • 2005 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 1999 - Fellow of the American Academy of Arts and Sciences
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

H F Bunn is affiliated with Harvard Medical School in the United States. Their research spans multiple fields with a primary focus on Medicine as well as contributions to Biochemistry, Genetics, and Molecular Biology.

The scientist's work extensively addresses topics relevant to hematology and molecular medicine, particularly concentrating on hemoglobin-related disorders and erythrocyte function. Their main topics of study include:

  • Hemoglobinopathies and Related Disorders
  • Hemoglobin structure and function
  • Erythrocyte Function and Pathophysiology
  • Heme Oxygenase-1 and Carbon Monoxide
  • Neurological and metabolic disorders
  • Myeloproliferative Neoplasms: Diagnosis and Treatment
  • Acute Myeloid Leukemia Research

In terms of subfields, their research contributions have been made in:

  • Genetics
  • Cell Biology
  • Physiology
  • Molecular Biology
  • Endocrinology, Diabetes and Metabolism

Recent publications by H F Bunn include:

  • Treatment of sickle cell disease by increasing oxygen affinity of hemoglobin, 2021, Blood
  • Oxygen Delivery in the Treatment of Anemia, 2022, New England Journal of Medicine
  • Therapeutic potential of the latest oxygen affinity-modifying agent, GBT021601, for treating sickle cell disease is questionable, 2024, British Journal of Haematology

Their work has appeared repeatedly in prominent venues such as:

  • Blood
  • New England Journal of Medicine
  • British Journal of Haematology

H F Bunn frequently collaborates with several researchers, including:

  • Belhu Metaferia
  • Troy Cellmer
  • Swee Lay Thein
  • William A. Eaton
  • Eric R. Henry

Throughout their career, H F Bunn has been recognized with professional honors such as:

  • Fellow of the American Association for the Advancement of Science (AAAS), 2005
  • Fellow of the American Academy of Arts and Sciences, 1999
  • Member of the Association of American Physicians

Best Publications

  • Regulation of hypoxia-inducible factor 1α is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway

    L. E. Huang;Jie Gu;M. Schau;H. F. Bunn

  • Analysis of cytokine mRNA and DNA: detection and quantitation by competitive polymerase chain reaction

    G Gilliland;S Perrin;K Blanchard;H F Bunn

  • Oxygen sensing and molecular adaptation to hypoxia

    H. F. Bunn;R. O. Poyton

  • Pathogenesis and Treatment of Sickle Cell Disease

    Bunn Hf

  • Regulation of the erythropoietin gene: evidence that the oxygen sensor is a heme protein

    MA Goldberg;SP Dunning;HF Bunn

  • The glycosylation of hemoglobin: relevance to diabetes mellitus

    HF Bunn;KH Gabbay;PM Gallop

  • Reaction of monosaccharides with proteins: possible evolutionary significance.

    HF Bunn;PJ Higgins

  • The biosynthesis of human hemoglobin A1c. Slow glycosylation of hemoglobin in vivo.

    H F Bunn;D N Haney;S Kamin;K H Gabbay

  • Glycosylated Hemoglobins and Long-Term Blood Glucose Control in Diabetes Mellitus

    K H Gabbay;K Hasty;J L Breslow;R C Ellison

  • Exchange of heme among hemoglobins and between hemoglobin and albumin.

    H F Bunn;J H Jandl

  • Nonenzymatic glycosylation of human serum albumin alters its conformation and function.

    N Shaklai;R L Garlick;H F Bunn

  • SITES OF NONENZYMATIC GLYCOSYLATION OF HUMAN HEMOGLOBIN A

    R Shapiro;M J McManus;C Zalut;H F Bunn

  • The regulated expression of erythropoietin by two human hepatoma cell lines.

    M A Goldberg;G A Glass;J M Cunningham;H F Bunn

  • The interaction of 2,3-diphosphoglycerate with various human hemoglobins

    Bunn Hf;Briehl Rw

  • Regulation of the Erythropoietin Gene

    S Imagawa;M A Goldberg;H F Bunn

  • The separation of human and animal hemoglobins by isoelectric focusing in polyacrylamide gel.

    Drysdale Jw;Righetti P;Bunn Hf

  • Kinetic analysis of the nonenzymatic glycosylation of hemoglobin

    P J Higgins;H F Bunn

  • Clinical consequences of acquired transfusional iron overload in adults.

    A I Schafer;R G Cheron;R Dluhy;B Cooper

  • REGULATION OF TRANSCRIPTION BY HYPOXIA REQUIRES A MULTIPROTEIN COMPLEX THAT INCLUDES HYPOXIA-INDUCIBLE FACTOR 1, AN ADJACENT TRANSCRIPTION FACTOR, AND P300/CREB BINDING PROTEIN

    B L Ebert;H F Bunn

  • Clonality in myeloproliferative disorders: analysis by means of the polymerase chain reaction.

    D G Gilliland;K L Blanchard;J Levy;S Perrin

Frequent Co-Authors

Kenneth H. Gabbay
Kenneth H. Gabbay Baylor College of Medicine
Robert Shapiro
Robert Shapiro New York University
Paul J. Higgins
Paul J. Higgins Albany Medical Center Hospital
David G. Nathan
David G. Nathan Harvard University
Carlo Brugnara
Carlo Brugnara Boston Children's Hospital
Barbara E. Bierer
Barbara E. Bierer Brigham and Women's Hospital
Alan N. Schechter
Alan N. Schechter National Institute of Diabetes and Digestive and Kidney Diseases
Julian Solway
Julian Solway University of Chicago
Sean Perrin
Sean Perrin Lund University
Robert E. Kingston
Robert E. Kingston Harvard University

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