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Christopher W. Pugh

Christopher W. Pugh

D-Index & Metrics

Biology and Biochemistry

D-Index
85
Citations
54280
World Ranking
3055
National Ranking
230

Overview

Christopher W. Pugh is affiliated with the University of Oxford in the United Kingdom. The main fields of their research include Medicine and Biochemistry, Genetics and Molecular Biology, with a focus on several subfields such as Molecular Biology, Cancer Research, Immunology, Genetics, and Cardiology and Cardiovascular Medicine.

Their work encompasses various main topics, including Cancer, Hypoxia, and Metabolism; High Altitude and Hypoxia; Immune cells in cancer; Congenital heart defects research; Epigenetics and DNA Methylation; Single-cell and spatial transcriptomics; and Immune Response and Inflammation.

Recent publications showcase the diversity and focus of their research. These include:

  • Multiparameter persistent homology landscapes identify immune cell spatial patterns in tumors, 2021, Proceedings of the National Academy of Sciences
  • Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation, 2022, Nature Immunology
  • Structural and non-coding variants increase the diagnostic yield of clinical whole genome sequencing for rare diseases, 2023, Genome Medicine
  • Marked and rapid effects of pharmacological HIF-2α antagonism on hypoxic ventilatory control, 2020, Journal of Clinical Investigation
  • Combining multiple spatial statistics enhances the description of immune cell localisation within tumours, 2020, Scientific Reports

Christopher W. Pugh frequently publishes in venues such as Cancer Research, Nature Communications, Nature Immunology, Scientific Reports, and Wellcome Open Research. Their contributions include five publications in Cancer Research, three in Nature Communications, two each in Nature Immunology and Scientific Reports, and two in Wellcome Open Research.

They often collaborate with other researchers in the field. Frequent co-authors include:

  • Peter J. Ratcliffe (12 collaborations)
  • Joanna D.C.C. Lima (8 collaborations)
  • Julie Adam (8 collaborations)
  • Samvid Kurlekar (7 collaborations)
  • David R. Mole (7 collaborations)

Best Publications

  • Targeting of HIF-alpha to the von Hippel-Lindau Ubiquitylation Complex by O2-Regulated Prolyl Hydroxylation

    Panu Jaakkola;David R. Mole;Ya-Min Tian;Michael I. Wilson

  • The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

    Patrick H. Maxwell;Michael S. Wiesener;Gin-Wen Chang;Steven C. Clifford

  • C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation.

    Andrew C.R. Epstein;Jonathan M. Gleadle;Luke A. McNeill;Kirsty S. Hewitson

  • Regulation of angiogenesis by hypoxia: role of the HIF system.

    Christopher W Pugh;Peter J Ratcliffe

  • The expression and distribution of the hypoxia-inducible factors HIF-1α and HIF-2α in normal human tissues, cancers, and tumor-associated macrophages

    Katherine L. Talks;Helen Turley;Kevin C. Gatter;Patrick H. Maxwell

  • Hypoxia-inducible Expression of Tumor-associated Carbonic Anhydrases

    Charles C. Wykoff;Nigel J. P. Beasley;Peter H. Watson;Kevin J. Turner

  • Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth.

    P H Maxwell;G U Dachs;J M Gleadle;L G Nicholls

  • Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein.

    Matthew E. Cockman;Norma Masson;David R. Mole;Panu Jaakkola

  • Independent function of two destruction domains in hypoxia-inducible factor-α chains activated by prolyl hydroxylation

    Norma Masson;Carsten Willam;Patrick H. Maxwell;Christopher W. Pugh

  • Differential Function of the Prolyl Hydroxylases PHD1, PHD2, and PHD3 in the Regulation of Hypoxia-inducible Factor *

    Rebecca J. Appelhoff;Ya-Min Tian;Raju R. Raval;Helen Turley

  • Contrasting Properties of Hypoxia-Inducible Factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-Associated Renal Cell Carcinoma

    Raju R. Raval;Kah Weng Lau;Maxine G. B. Tran;Heidi M. Sowter

  • Widespread hypoxia-inducible expression of HIF-2alpha in distinct cell populations of different organs.

    Michael S Wiesener;Jan Steffen Jürgensen;Christian Rosenberger;Charlotte K Scholze

  • Hypoxia-inducible Factor (HIF) Asparagine Hydroxylase Is Identical to Factor Inhibiting HIF (FIH) and Is Related to the Cupin Structural Family

    Kirsty S. Hewitson;Luke A. McNeill;Madeline V. Riordan;Ya-Min Tian

  • Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL.

    Wai-Ching Hon;Michael I. Wilson;Karl Harlos;Timothy D. W. Claridge

  • Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1alpha.

    M.S. Wiesener;H. Turley;H. Turley;William Allen;William Allen;C. Willam;C. Willam

  • High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq

    Johannes Schödel;Spyros Oikonomopoulos;Jiannis Ragoussis;Christopher W. Pugh

  • Activation of hypoxia-inducible factor-1; definition of regulatory domains within the alpha subunit.

    Christopher W. Pugh;John F. O'Rourke;Masaya Nagao;Jonathan M. Gleadle

  • Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: similarities with the erythropoietin 3' enhancer.

    J D Firth;B L Ebert;C W Pugh;P J Ratcliffe

  • Renal Cyst Formation in Fh1-Deficient Mice Is Independent of the Hif/Phd Pathway: Roles for Fumarate in KEAP1 Succination and Nrf2 Signaling

    Julie Adam;Emine Hatipoglu;Linda O'Flaherty;Nicola Ternette

  • Activation of the HIF pathway in cancer

    Patrick H Maxwell;Christopher W Pugh;Peter J Ratcliffe

Frequent Co-Authors

Peter J. Ratcliffe
Peter J. Ratcliffe The Francis Crick Institute
Patrick H. Maxwell
Patrick H. Maxwell University of Cambridge
Christopher J. Schofield
Christopher J. Schofield University of Oxford
Benedikt M. Kessler
Benedikt M. Kessler University of Oxford
Rafael Perera
Rafael Perera University of Oxford
Helen M. Colhoun
Helen M. Colhoun University of Edinburgh
Lionel Tarassenko
Lionel Tarassenko University of Oxford
Philip Clarke
Philip Clarke University of Oxford
adrian l harris
adrian l harris University of Oxford

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