His primary areas of investigation include Hypoxia-inducible factors, Transcription factor, Molecular biology, Biochemistry and Hypoxia-Inducible Factor 1. His study in Hypoxia-inducible factors is interdisciplinary in nature, drawing from both Downregulation and upregulation and Signal transduction, Cell biology. He has included themes like Hypoxia, Gene expression and G alpha subunit in his Transcription factor study.
In his study, which falls under the umbrella issue of Hypoxia-Inducible Factor 1, Neovascularization is strongly linked to Transcriptional regulation. His Hydroxylation study integrates concerns from other disciplines, such as Hypoxia-Inducible Factor-Proline Dioxygenases, Ubiquitin, Ubiquitin ligase and EGLN1. Christopher W. Pugh works mostly in the field of EGLN1, limiting it down to topics relating to Hypoxia-Inducible Factor Pathway and, in certain cases, Hypoxia Pathway and Von Hippel–Lindau tumor suppressor, as a part of the same area of interest.
Christopher W. Pugh mainly focuses on Hypoxia-inducible factors, Biochemistry, Internal medicine, Cell biology and Transcription factor. His research in Hypoxia-inducible factors intersects with topics in Procollagen-proline dioxygenase, Angiogenesis, HIF1A and Signal transduction. The Internal medicine study combines topics in areas such as Endocrinology and Cardiology.
His Cell biology study combines topics in areas such as Cell, Regulation of gene expression and Transcriptional regulation. His research integrates issues of Ubiquitin ligase, Gene expression and G alpha subunit in his study of Transcription factor. As a part of the same scientific study, he usually deals with the Gene expression, concentrating on Molecular biology and frequently concerns with Transfection and Erythropoietin.
His primary scientific interests are in Internal medicine, Cardiology, Hypoxia, Cell biology and Hypoxia-inducible factors. When carried out as part of a general Internal medicine research project, his work on Hemodialysis, Dialysis, Heart rate variability and Autonomic nervous system is frequently linked to work in Tetanus, therefore connecting diverse disciplines of study. Within one scientific family, Christopher W. Pugh focuses on topics pertaining to Blood pressure under Cardiology, and may sometimes address concerns connected to Cluster analysis and Kidney disease.
His Cell biology research integrates issues from Immunology, T cell, Oxygen homeostasis and Tumor microenvironment. Hypoxia-inducible factors is the subject of his research, which falls under Biochemistry. His Hydroxylation research is multidisciplinary, incorporating elements of Transcription factor, Transcription and HIF1A.
Christopher W. Pugh mostly deals with Cell biology, Internal medicine, Hypoxia-inducible factors, Oxygen homeostasis and Immunology. Christopher W. Pugh has researched Cell biology in several fields, including Gene silencing and Immune system. His Internal medicine research incorporates themes from Intracellular and Cardiology.
His work deals with themes such as Oxygenase and Hydroxylation, which intersect with Hypoxia-inducible factors. The study incorporates disciplines such as Downregulation and upregulation and Pharmacology in addition to Hydroxylation. The Oxygen homeostasis study which covers Secretion that intersects with Cell.
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Targeting of HIF-alpha to the von Hippel-Lindau Ubiquitylation Complex by O2-Regulated Prolyl Hydroxylation
Panu Jaakkola;David R. Mole;Ya-Min Tian;Michael I. Wilson.
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
Patrick H. Maxwell;Michael S. Wiesener;Gin-Wen Chang;Steven C. Clifford.
C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation.
Andrew C.R. Epstein;Jonathan M. Gleadle;Luke A. McNeill;Kirsty S. Hewitson.
Regulation of angiogenesis by hypoxia: role of the HIF system.
Christopher W Pugh;Peter J Ratcliffe.
Nature Medicine (2003)
The expression and distribution of the hypoxia-inducible factors HIF-1α and HIF-2α in normal human tissues, cancers, and tumor-associated macrophages
Katherine L. Talks;Helen Turley;Kevin C. Gatter;Patrick H. Maxwell.
American Journal of Pathology (2000)
Hypoxia-inducible Expression of Tumor-associated Carbonic Anhydrases
Charles C. Wykoff;Nigel J. P. Beasley;Peter H. Watson;Kevin J. Turner.
Cancer Research (2000)
Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein.
Matthew E. Cockman;Norma Masson;David R. Mole;Panu Jaakkola.
Journal of Biological Chemistry (2000)
Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth.
P H Maxwell;G U Dachs;J M Gleadle;L G Nicholls.
Proceedings of the National Academy of Sciences of the United States of America (1997)
Independent function of two destruction domains in hypoxia-inducible factor-α chains activated by prolyl hydroxylation
Norma Masson;Carsten Willam;Patrick H. Maxwell;Christopher W. Pugh.
The EMBO Journal (2001)
Differential Function of the Prolyl Hydroxylases PHD1, PHD2, and PHD3 in the Regulation of Hypoxia-inducible Factor *
Rebecca J. Appelhoff;Ya-Min Tian;Raju R. Raval;Helen Turley.
Journal of Biological Chemistry (2004)
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