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Medicine

D-Index
101
Citations
62023
World Ranking
7800
National Ranking
765

Overview

Patrick H. Maxwell is affiliated with the University of Cambridge in the United Kingdom. Their research spans multiple topics primarily within biochemistry, genetics, and molecular biology, along with significant work in medicine.

The main fields of study associated with their work include:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Within these fields, their subfields of focus are:

  • Molecular Biology
  • Infectious Diseases
  • Immunology
  • Cancer Research
  • Hematology

The scientific topics covered in their research include:

  • Cancer, Hypoxia, and Metabolism
  • SARS-CoV-2 and COVID-19 Research
  • Single-cell and spatial transcriptomics
  • Immune cells in cancer
  • COVID-19 Clinical Research Studies
  • SARS-CoV-2 detection and testing
  • Epigenetics and DNA Methylation

Patrick H. Maxwell has published extensively in several venues, with frequent publications in the following journals:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature
  • Cell
  • Nature Genetics
  • Nature Immunology

Some of their recent papers include:

  • Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball-patterned arrays, 2022, Cell
  • Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity, 2022, Nature
  • Age-related immune response heterogeneity to SARS-CoV-2 vaccine BNT162b2, 2021, Nature
  • Rolling back human pluripotent stem cells to an eight-cell embryo-like stage, 2022, Nature
  • Cell transcriptomic atlas of the non-human primate Macaca fascicularis, 2022, Nature

They have collaborated frequently with several co-authors, including:

  • Miguel A. Esteban
  • Yiwei Lai
  • Longqi Liu
  • Chuanyu Liu
  • Paul Lyons

Best Publications

  • Targeting of HIF-alpha to the von Hippel-Lindau Ubiquitylation Complex by O2-Regulated Prolyl Hydroxylation

    Panu Jaakkola;David R. Mole;Ya-Min Tian;Michael I. Wilson

  • The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

    Patrick H. Maxwell;Michael S. Wiesener;Gin-Wen Chang;Steven C. Clifford

  • Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis.

    Peter Carmeliet;Yuval Dor;Jean-Marc Herbert;Dai Fukumura

  • The expression and distribution of the hypoxia-inducible factors HIF-1α and HIF-2α in normal human tissues, cancers, and tumor-associated macrophages

    Katherine L. Talks;Helen Turley;Kevin C. Gatter;Patrick H. Maxwell

  • Hypoxia-inducible Expression of Tumor-associated Carbonic Anhydrases

    Charles C. Wykoff;Nigel J. P. Beasley;Peter H. Watson;Kevin J. Turner

  • Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth.

    P H Maxwell;G U Dachs;J M Gleadle;L G Nicholls

  • Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein.

    Matthew E. Cockman;Norma Masson;David R. Mole;Panu Jaakkola

  • Independent function of two destruction domains in hypoxia-inducible factor-α chains activated by prolyl hydroxylation

    Norma Masson;Carsten Willam;Patrick H. Maxwell;Christopher W. Pugh

  • Contrasting Properties of Hypoxia-Inducible Factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-Associated Renal Cell Carcinoma

    Raju R. Raval;Kah Weng Lau;Maxine G. B. Tran;Heidi M. Sowter

  • Widespread hypoxia-inducible expression of HIF-2alpha in distinct cell populations of different organs.

    Michael S Wiesener;Jan Steffen Jürgensen;Christian Rosenberger;Charlotte K Scholze

  • Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization

    Massimiliano Mazzone;Massimiliano Mazzone;Daniela Dettori;Daniela Dettori;Daniela Dettori;Rodrigo Leite de Oliveira;Rodrigo Leite de Oliveira;Sonja Loges;Sonja Loges

  • Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1alpha.

    M.S. Wiesener;H. Turley;H. Turley;William Allen;William Allen;C. Willam;C. Willam

  • Expression of hypoxia-inducible factor-1alpha and -2alpha in hypoxic and ischemic rat kidneys.

    Christian Rosenberger;Stefano Mandriota;Jan Steffen Jürgensen;Michael S. Wiesener

  • Single-cell transcriptomes from human kidneys reveal the cellular identity of renal tumors

    Matthew D. Young;Thomas J. Mitchell;Thomas J. Mitchell;Thomas J. Mitchell;Felipe A. Vieira Braga;Maxine G. B. Tran

  • HIF activation identifies early lesions in VHL kidneys: Evidence for site-specific tumor suppressor function in the nephron

    Stefano J Mandriota;Kevin J Turner;David R Davies;Paul G Murray

  • Renal Cyst Formation in Fh1-Deficient Mice Is Independent of the Hif/Phd Pathway: Roles for Fumarate in KEAP1 Succination and Nrf2 Signaling

    Julie Adam;Emine Hatipoglu;Linda O'Flaherty;Nicola Ternette

  • Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia

    Sonny O. Ang;Hua Chen;Kiichi Hirota;Victor R. Gordeuk

  • Activation of the HIF pathway in cancer

    Patrick H Maxwell;Christopher W Pugh;Peter J Ratcliffe

  • Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism

    Julián Aragonés;Martin Schneider;Martin Schneider;Martin Schneider;Katie Van Geyte;Katie Van Geyte;Peter Fraisl;Peter Fraisl

  • Identification of the renal erythropoietin-producing cells using transgenic mice

    Patrick H. Maxwell;Mark K. Osmond;Mark K. Osmond;Christopher W. Pugh;Christopher W. Pugh;Andrew Heryet;Andrew Heryet

Frequent Co-Authors

Peter J. Ratcliffe
Peter J. Ratcliffe The Francis Crick Institute
Christopher W. Pugh
Christopher W. Pugh University of Oxford
Miguel A. Esteban
Miguel A. Esteban Guangzhou Institutes of Biomedicine and Health
adrian l harris
adrian l harris University of Oxford
Christopher J. Schofield
Christopher J. Schofield University of Oxford
Eamonn R. Maher
Eamonn R. Maher University of Cambridge
Martin H. Johnson
Martin H. Johnson University of Cambridge
Robin R. Ali
Robin R. Ali King's College London

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