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Genetics

D-Index
44
Citations
8474
World Ranking
4258
National Ranking
9

Overview

Lumir Krejci is affiliated with Masaryk University in the Czech Republic. Their research primarily spans the field of Biochemistry, Genetics, and Molecular Biology, with a significant concentration in Molecular Biology. Additional subfields include Oncology, Plant Science, Physiology, and Molecular Medicine.

The main topics covered in Lumir Krejci's work include DNA Repair Mechanisms, CRISPR and Genetic Engineering, RNA Research and Splicing, RNA regulation and disease, PARP inhibition in cancer therapy, RNA and protein synthesis mechanisms, and RNA Interference and Gene Delivery.

Frequent co-authors in Krejci's publications include Mário Špı́rek, Victoria Marini, Jakub Cibulka, Fedor Nikulenkov, and Prashant Khirsariya.

Krejci's research has appeared extensively in several publication venues. Notable frequent venues include Nucleic Acids Research, Nature Communications, bioRxiv (Cold Spring Harbor Laboratory), Scientific Reports, and iScience.

Selected recent papers from Lumir Krejci's work include:

  • MutSβ-MutLβ-FANCJ axis mediates the restart of DNA replication after fork stalling at cotranscriptional G4/R-loops, 2024, Science Advances
  • RAD51-dependent recruitment of TERRA lncRNA to telomeres through R-loops, 2020, Nature
  • The CHK1 inhibitor MU380 significantly increases the sensitivity of human docetaxel-resistant prostate cancer cells to gemcitabine through the induction of mitotic catastrophe, 2020, Molecular Oncology
  • Single-molecule visualization of human RECQ5 interactions with single-stranded DNA recombination intermediates, 2020, Nucleic Acids Research
  • Antibiotic-induced DNA damage results in a controlled loss of pH homeostasis and genome instability, 2020, Scientific Reports

Best Publications

  • Homologous recombination and its regulation

    Lumir Krejci;Veronika Altmannova;Mario Spirek;Xiaolan Zhao

  • DNA helicase Srs2 disrupts the Rad51 presynaptic filament

    Lumir Krejci;Stephen Van Komen;Ying Li;Jana Villemain

  • Crosstalk between SUMO and ubiquitin on PCNA is mediated by recruitment of the helicase Srs2p.

    Efterpi Papouli;Shuhua Chen;Shuhua Chen;Adelina A. Davies;Diana Huttner

  • Rad51 Recombinase and Recombination Mediators

    Patrick Sung;Lumir Krejci;Stephen Van Komen;Michael G. Sehorn

  • SAMHD1 acts at stalled replication forks to prevent interferon induction

    Flavie Coquel;Maria-Joao Silva;Maria-Joao Silva;Hervé Técher;Karina Zadorozhny

  • Smarcal1-Mediated Fork Reversal Triggers Mre11-Dependent Degradation of Nascent DNA in the Absence of Brca2 and Stable Rad51 Nucleofilaments.

    Arun Mouli Kolinjivadi;Vincenzo Sannino;Anna De Antoni;Karina Zadorozhny

  • Yeast Mph1 helicase dissociates Rad51-made D-loops: implications for crossover control in mitotic recombination

    Rohit Prakash;Dominik Satory;Eloïse Dray;Almas Papusha

  • Srs2 disassembles Rad51 filaments by a protein-protein interaction triggering ATP turnover and dissociation of Rad51 from DNA.

    Edwin Antony;Eric J. Tomko;Qi Xiao;Lumir Krejci

  • Biochemical characterization of the RECQ4 protein, mutated in Rothmund-Thomson syndrome.

    Margaret A. Macris;Lumir Krejci;Wendy Bussen;Akira Shimamoto

  • RAD51-dependent recruitment of TERRA lncRNA to telomeres through R-loops.

    Marianna Feretzaki;Michaela Pospisilova;Rita Valador Fernandes;Thomas Lunardi

  • Recombination mediator and Rad51 targeting activities of a human BRCA2 polypeptide.

    Joseph San Filippo;Peter Chi;Michael G. Sehorn;Julia Etchin

  • Rad51 Paralogs Remodel Pre-synaptic Rad51 Filaments to Stimulate Homologous Recombination.

    Martin R.G. Taylor;Mário Špírek;Kathy R. Chaurasiya;Jordan D. Ward;Jordan D. Ward

  • Interaction with Rad51 Is Indispensable for Recombination Mediator Function of Rad52

    Lumir Krejci;Binwei Song;Wendy Bussen;Rodney Rothstein

  • PRDM9 interactions with other proteins provide a link between recombination hotspots and the chromosomal axis in meiosis.

    Emil Damyanov Parvanov;Hui Tian;Timothy Billings;Ruth L. Saxl

  • Saccharomyces cerevisiae MPH1 gene, required for homologous recombination-mediated mutation avoidance, encodes a 3' to 5' DNA helicase.

    Rohit Prakash;Lumir Krejci;Stephen Van Komen;Kirsten Anke Schürer

  • Interaction with RPA is necessary for Rad52 repair center formation and for its mediator activity

    Iben Plate;Swee Chuang Lim Hallwyl;Idina Shi;Lumir Krejci

  • Rad52 SUMOylation affects the efficiency of the DNA repair

    Veronika Altmannova;Nadine Eckert-Boulet;Milica Arneric;Peter Kolesar

  • Cdk1 targets Srs2 to complete synthesis-dependent strand annealing and to promote recombinational repair.

    Marco Saponaro;Devon Callahan;Xiuzhong Zheng;Lumir Krejci

  • Srs2: the "Odd-Job Man" in DNA repair.

    Victoria Marini;Lumir Krejci

  • Molecular dissection of interactions between Rad51 and members of the recombination-repair group.

    Lumir Krejci;Jiri Damborsky;Bo Thomsen;Morten Duno

Frequent Co-Authors

Patrick Sung
Patrick Sung The University of Texas Health Science Center at San Antonio
Michael Lisby
Michael Lisby University of Copenhagen
Christian Bendixen
Christian Bendixen Aarhus University
Hannah L. Klein
Hannah L. Klein New York University
Lajos Haracska
Lajos Haracska Biological Research Centre
Jiri Damborsky
Jiri Damborsky Masaryk University
Simon J. Boulton
Simon J. Boulton The Francis Crick Institute
Eric C. Greene
Eric C. Greene Columbia University
Rodney Rothstein
Rodney Rothstein Columbia University
Vincenzo Costanzo
Vincenzo Costanzo University of Catania

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