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Vincenzo Costanzo

Vincenzo Costanzo

D-Index & Metrics

Biology and Biochemistry

D-Index
58
Citations
12005
World Ranking
13181
National Ranking
396

Overview

Vincenzo Costanzo is affiliated with the University of Catania in Italy and has contributed extensively to research in biochemistry, genetics, and molecular biology. Their work primarily focuses on molecular biology, with significant contributions in oncology, cell biology, genetics, and pulmonary and respiratory medicine.

The scientific contributions of Vincenzo Costanzo cover a range of topics, including:

  • DNA Repair Mechanisms
  • Genomics and Chromatin Dynamics
  • Epigenetics and DNA Methylation
  • CRISPR and Genetic Engineering
  • PARP inhibition in cancer therapy
  • RNA Research and Splicing
  • Nuclear Structure and Function

The researcher has published in several prominent venues, with the most frequent being:

  • Molecular Cell
  • Cell Reports
  • Scientific Reports
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications

Among their recent publications are:

  • REV1-Polζ maintains the viability of homologous recombination-deficient cancer cells through mutagenic repair of PRIMPOL-dependent ssDNA gaps, 2021, Molecular Cell
  • Physiological Tolerance to ssDNA Enables Strand Uncoupling during DNA Replication, 2020, Cell Reports
  • POLθ prevents MRE11-NBS1-CtIP-dependent fork breakage in the absence of BRCA2/RAD51 by filling lagging-strand gaps, 2022, Molecular Cell
  • POLθ processes ssDNA gaps and promotes replication fork progression in BRCA1-deficient cells, 2022, Cell Reports
  • ATR expands embryonic stem cell fate potential in response to replication stress, 2020, eLife

Vincenzo Costanzo collaborates with various co-authors, notably:

  • Angela Bachi
  • Vincenzo Sannino
  • Lucia Falbo
  • Yodhara Wijesekara Hanthi
  • Miguel Angel Ramírez-Otero

The breadth of publications spans 65 works in the overarching field of biochemistry, genetics, and molecular biology, with 58 focused on molecular biology, reflecting a concentrated research emphasis. Contributions also include studies in oncology and genetics, as well as related biomedical fields.

Best Publications

  • Amyloid β-peptide inhibition of the PKA/CREB pathway and long-term potentiation: Reversibility by drugs that enhance cAMP signaling

    Ottavio V. Vitolo;Antonino Sant'Angelo;Vincenzo Costanzo;Fortunato Battaglia

  • Rad51 protects nascent DNA from Mre11-dependent degradation and promotes continuous DNA synthesis

    Yoshitami Hashimoto;Arnab Ray Chaudhuri;Massimo Lopes;Vincenzo Costanzo

  • Topoisomerase I poisoning results in PARP-mediated replication fork reversal

    Arnab Ray Chaudhuri;Yoshitami Hashimoto;Raquel Herrador;Kai J Neelsen

  • ATR and ATM regulate the timing of DNA replication origin firing.

    David Shechter;David Shechter;Vincenzo Costanzo;Jean Gautier

  • ATM activates the pentose phosphate pathway promoting anti‐oxidant defence and DNA repair

    Claudia Cosentino;Domenico Grieco;Vincenzo Costanzo

  • An ATR- and Cdc7-Dependent DNA Damage Checkpoint that Inhibits Initiation of DNA Replication

    Vincenzo Costanzo;David Shechter;Patrick J Lupardus;Karlene A Cimprich

  • SAMHD1 acts at stalled replication forks to prevent interferon induction

    Flavie Coquel;Maria-Joao Silva;Maria-Joao Silva;Hervé Técher;Karina Zadorozhny

  • Restoration of Replication Fork Stability in BRCA1- and BRCA2-Deficient Cells by Inactivation of SNF2-Family Fork Remodelers.

    Angelo Taglialatela;Silvia Alvarez;Giuseppe Leuzzi;Vincenzo Sannino

  • Smarcal1-Mediated Fork Reversal Triggers Mre11-Dependent Degradation of Nascent DNA in the Absence of Brca2 and Stable Rad51 Nucleofilaments.

    Arun Mouli Kolinjivadi;Vincenzo Sannino;Anna De Antoni;Karina Zadorozhny

  • Mre11 Protein Complex Prevents Double-Strand Break Accumulation during Chromosomal DNA Replication

    Vincenzo Costanzo;Kirsten Robertson;Marina Bibikova;Edward Kim

  • Regulation of DNA replication by ATR: signaling in response to DNA intermediates.

    David Shechter;Vincenzo Costanzo;Jean Gautier

  • ATM and ATR promote Mre11 dependent restart of collapsed replication forks and prevent accumulation of DNA breaks

    Kristina Trenz;Eloise Smith;Sarah Smith;Vincenzo Costanzo

  • Reconstitution of an ATM-Dependent Checkpoint that Inhibits Chromosomal DNA Replication following DNA Damage

    Vincenzo Costanzo;Kirsten Robertson;Carol Y. Ying;Edward Kim

  • Polo-like kinase 1 reaches beyond mitosis--cytokinesis, DNA damage response, and development.

    Tohru Takaki;Kristina Trenz;Vincenzo Costanzo;Mark Petronczki

  • RNase H and Postreplication Repair Protect Cells from Ribonucleotides Incorporated in DNA

    Federico Lazzaro;Daniele Novarina;Flavio Amara;Danielle L. Watt

  • Energy savings in buildings or UHI mitigation? Comparison between green roofs and cool roofs

    Vincenzo Costanzo;G. Evola;L. Marletta

  • RAD51- and MRE11-dependent reassembly of uncoupled CMG helicase complex at collapsed replication forks

    Yoshitami Hashimoto;Fabio Puddu;Vincenzo Costanzo

  • Mechanisms of replication fork protection: a safeguard for genome stability

    Alessia Errico;Vincenzo Costanzo

  • Moonlighting at replication forks – a new life for homologous recombination proteins BRCA1, BRCA2 and RAD51

    Arun Mouli Kolinjivadi;Vincenzo Sannino;Anna de Antoni;Hervé Técher

  • Mre11-Rad50-Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity.

    Ali Jazayeri;Alessia Balestrini;Elizabeth Garner;James E Haber

Frequent Co-Authors

Jean Gautier
Jean Gautier Columbia University
Runming Yao
Runming Yao University of Reading
Max E. Gottesman
Max E. Gottesman Columbia University Medical Center
Baizhan Li
Baizhan Li Chongqing University
Angela Bachi
Angela Bachi FIRC Institute of Molecular Oncology
Claudio Tripodo
Claudio Tripodo FIRC Institute of Molecular Oncology
Enrico V. Avvedimento
Enrico V. Avvedimento University of Naples Federico II
Lumir Krejci
Lumir Krejci Masaryk University
Alfredo Fusco
Alfredo Fusco University of Naples Federico II
James E. Haber
James E. Haber Brandeis University

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