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Microbiology

D-Index
69
Citations
15283
World Ranking
2074
National Ranking
872

Overview

David H. Margulies is affiliated with the National Institutes of Health in the United States. Their research primarily spans Immunology and Microbiology, Medicine, and Biochemistry, Genetics and Molecular Biology, with notable contributions in subfields including Immunology, Molecular Biology, Radiology, Nuclear Medicine and Imaging, Infectious Diseases, and Oncology.

The scientist's research topics focus on several key areas: monoclonal and polyclonal antibodies research, immune cell function and interaction, immunotherapy and immune responses, vaccines and immunoinformatics approaches, SARS-CoV-2 and COVID-19 research, T-cell and B-cell immunology, as well as glycosylation and glycoproteins research.

David H. Margulies has authored a range of papers covering structural mechanisms and antigen presentation pathways, including the following recent publications:

  • Structural mechanism of tapasin-mediated MHC-I peptide loading in antigen presentation, 2022, Nature Communications
  • Structures of synthetic nanobody-SARS-CoV-2 receptor-binding domain complexes reveal distinct sites of interaction, 2021, Journal of Biological Chemistry
  • Structural and dynamic studies of TAPBPR and Tapasin reveal the mechanism of peptide loading of MHC-I molecules, 2020, Current Opinion in Immunology
  • Alterations in the HLA-B*57:01 Immunopeptidome by Flucloxacillin and Immunogenicity of Drug-Haptenated Peptides, 2021, Frontiers in Immunology
  • Chaperones and Catalysts: How Antigen Presentation Pathways Cope With Biological Necessity, 2022, Frontiers in Immunology

Their frequent co-authors include:

  • Lisa F. Boyd
  • Jiansheng Jiang
  • Kannan Natarajan
  • Javeed Ahmad
  • Natarajan Kannan

David H. Margulies has published extensively in several venues, notably:

  • The Journal of Immunology
  • Acta Crystallographica Section A Foundations and Advances
  • Frontiers in Immunology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications

Best Publications

  • The biochemistry and cell biology of antigen processing and presentation

    R N Germain;D H Margulies

  • A simple method for polyethylene glycol-promoted hybridization of mouse myeloma cells.

    Malcolm L. Gefter;David H. Margulies;Matthew D. Scharff

  • T cell receptor-MHC class I peptide interactions: affinity, kinetics, and specificity

    Maripat Corr;Alfred E. Slanetz;Lisa F. Boyd;Marie T. Jelonek

  • Structure and Function of Natural Killer Cell Receptors: Multiple Molecular Solutions to Self, Nonself Discrimination*

    Kannan Natarajan;Nazzareno Dimasi;Jian Wang;Roy A. Mariuzza

  • Enhanced Antigen-Specific Antitumor Immunity with Altered Peptide Ligands that Stabilize the MHC-Peptide-TCR Complex

    Jill E Slansky;Frédérique M Rattis;Lisa F Boyd;Tarek Fahmy

  • Crystal Structure of a Lectin-Like Natural Killer Cell Receptor Bound to its Mhc Class I Ligand

    José Tormo;Kannan Natarajan;David H. Margulies;Roy A. Mariuzza

  • The TLR3 signaling complex forms by cooperative receptor dimerization

    Joshua N. Leonard;Rodolfo Ghirlando;Janine Askins;Jessica K. Bell

  • Determinant selection of major histocompatibility complex class I-restricted antigenic peptides is explained by class I-peptide affinity and is strongly influenced by nondominant anchor residues.

    Weisan Chen;Sergei Khilko;John Fecondo;David H. Margulies

  • Exon shuffling: mapping polymorphic determinants on hybrid mouse transplantation antigens

    Glen A. Evans;David H. Margulies;Benjamin Shykind;J. G. Seidman

  • Abacavir induces loading of novel self-peptides into HLA-B*57:01: an autoimmune model for HLA-associated drug hypersensitivity

    Michael A. Norcross;Shen Luo;Li Lu;Michael T. Boyne

  • Structure and expression of a mouse major histocompatibility antigen gene, H-2Ld

    G A Evans;D H Margulies;R D Camerini-Otero;K Ozato

  • A targeted glucocorticoid receptor antisense transgene increases thymocyte apoptosis and alters thymocyte development.

    Leslie B. King;Melanie S. Vacchio;Katherine Dixon;Rosemarie Hunziker

  • Somatic cell hybridization of mouse myeloma cells

    David H. Margulies;W. Michael Kuehl;Matthew D. Scharff

  • Peptide Libraries Define the Fine Specificity of Anti-polysaccharide Antibodies to Cryptococcus neoformans

    Philippe Valadon;Gabriel Nussbaum;Gabriel Nussbaum;Lisa F. Boyd;Lisa F. Boyd;David H. Margulies;David H. Margulies

  • Lack of strict correlation of functional sensitization with the apparent affinity of MHC/peptide complexes for the TCR.

    B. K. Al-Ramadi;M. T. Jelonek;L. F. Boyd;D. H. Margulies

  • Endogenous peptides of a soluble major histocompatibility complex class I molecule, H-2Lds: sequence motif, quantitative binding, and molecular modeling of the complex.

    M Corr;L F Boyd;S R Frankel;S Kozlowski

  • Host MHC class I molecules modulate in vivo expression of a NK cell receptor.

    F M Karlhofer;R Hunziker;A Reichlin;D H Margulies

  • Peptide and beta 2-microglobulin regulation of cell surface MHC class I conformation and expression.

    G R Otten;E Bikoff;R K Ribaudo;S Kozlowski

  • Expression of H-2Dd and H-2Ld mouse major histocompatibility antigen genes in L cells after DNA-mediated gene transfer.

    D H Margulies;G A Evans;K Ozato;R D Camerini-Otero

  • Excess beta 2 microglobulin promoting functional peptide association with purified soluble class I MHC molecules.

    Steven Kozlowski;Toshiyuki Takeshita;Wolf-Henning Boehncke;Hidemi Takahashi;Hidemi Takahashi

Frequent Co-Authors

James McCluskey
James McCluskey University of Melbourne
Jay A. Berzofsky
Jay A. Berzofsky National Institutes of Health
Ronald N. Germain
Ronald N. Germain National Institute of Allergy and Infectious Diseases
Roy A. Mariuzza
Roy A. Mariuzza University of Maryland, College Park
Jonathan G. Seidman
Jonathan G. Seidman Harvard University
John E. Coligan
John E. Coligan National Institutes of Health
Ethan M. Shevach
Ethan M. Shevach National Institute of Allergy and Infectious Diseases
Peter Schuck
Peter Schuck National Institutes of Health
Howard Robinson
Howard Robinson Brookhaven National Laboratory
Wayne M. Yokoyama
Wayne M. Yokoyama Washington University in St. Louis

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