H-Index & Metrics Best Publications

H-Index & Metrics

Discipline name H-index Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 62 Citations 12,972 174 World Ranking 4927 National Ranking 2379

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • DNA
  • Immune system

David H. Margulies mostly deals with Major histocompatibility complex, Molecular biology, MHC class I, Peptide and Antigen. His Major histocompatibility complex research includes elements of Cytotoxic T cell, CD8, Stereochemistry and T-cell receptor. David H. Margulies focuses mostly in the field of Molecular biology, narrowing it down to matters related to Cell culture and, in some cases, Neoplasm, Tissue culture, Endocrinology and Autoimmunity.

His studies in MHC class I integrate themes in fields like Receptor, Macromolecule and Cell biology. His studies deal with areas such as Epitope, Peptide sequence, Human leukocyte antigen and Monoclonal antibody as well as Peptide. His research in Antigen intersects with topics in Antibody, Gene and Antigen presentation.

His most cited work include:

  • The biochemistry and cell biology of antigen processing and presentation (928 citations)
  • A simple method for polyethylene glycol-promoted hybridization of mouse myeloma cells. (608 citations)
  • Structure and Function of Natural Killer Cell Receptors: Multiple Molecular Solutions to Self, Nonself Discrimination* (303 citations)

What are the main themes of his work throughout his whole career to date?

David H. Margulies focuses on Major histocompatibility complex, MHC class I, Molecular biology, Antigen and Peptide. His study looks at the relationship between Major histocompatibility complex and fields such as T-cell receptor, as well as how they intersect with chemical problems. The concepts of his MHC class I study are interwoven with issues in Natural killer cell, Receptor, Peptide sequence, Peptide binding and Cell biology.

His study in Molecular biology is interdisciplinary in nature, drawing from both Gene, Epitope, Antibody, Monoclonal antibody and CTL*. His Antigen research includes themes of Recombinant DNA and Transfection. His biological study spans a wide range of topics, including Biophysics, Stereochemistry, Antigen presentation and Binding site.

He most often published in these fields:

  • Major histocompatibility complex (47.20%)
  • MHC class I (37.38%)
  • Molecular biology (35.05%)

What were the highlights of his more recent work (between 2010-2021)?

  • MHC class I (37.38%)
  • Major histocompatibility complex (47.20%)
  • Peptide (27.10%)

In recent papers he was focusing on the following fields of study:

His scientific interests lie mostly in MHC class I, Major histocompatibility complex, Peptide, Cell biology and Biophysics. His MHC class I research integrates issues from Natural killer cell, Chaperone and Molecular biology. His Major histocompatibility complex research incorporates themes from T cell, Antigen presentation and Virology.

The study incorporates disciplines such as Epitope and Cytotoxic T cell in addition to Virology. His Peptide study is concerned with Biochemistry in general. His Cell biology research is multidisciplinary, relying on both Receptor, Antigen processing, Antigen and T-cell receptor.

Between 2010 and 2021, his most popular works were:

  • Abacavir induces loading of novel self-peptides into HLA-B*57:01: an autoimmune model for HLA-associated drug hypersensitivity (150 citations)
  • Crystal structure of a TAPBPR-MHC I complex reveals the mechanism of peptide editing in antigen presentation. (63 citations)
  • Interaction of TAPBPR, a tapasin homolog, with MHC-I molecules promotes peptide editing (45 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • DNA
  • Immune system

His primary scientific interests are in Major histocompatibility complex, MHC class I, Cell biology, Tapasin and Peptide. David H. Margulies has researched Major histocompatibility complex in several fields, including Allosteric regulation, Antigen presentation and Virology. His MHC class I research incorporates elements of Natural killer cell and Function.

David H. Margulies has included themes like Receptor, Toll-like receptor, Molecular biology and T-cell receptor in his Cell biology study. His study in Antigen extends to T-cell receptor with its themes. David H. Margulies combines subjects such as Biophysics, Peptide binding and Peptide sequence with his study of Peptide.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

The biochemistry and cell biology of antigen processing and presentation

R N Germain;D H Margulies.
Annual Review of Immunology (1993)

1283 Citations

A simple method for polyethylene glycol-promoted hybridization of mouse myeloma cells.

Malcolm L. Gefter;David H. Margulies;Matthew D. Scharff.
Somatic Cell and Molecular Genetics (1977)

807 Citations

T cell receptor-MHC class I peptide interactions: affinity, kinetics, and specificity

Maripat Corr;Alfred E. Slanetz;Lisa F. Boyd;Marie T. Jelonek.
Science (1994)

421 Citations

Structure and Function of Natural Killer Cell Receptors: Multiple Molecular Solutions to Self, Nonself Discrimination*

Kannan Natarajan;Nazzareno Dimasi;Jian Wang;Roy A. Mariuzza.
Annual Review of Immunology (2002)

418 Citations

Enhanced Antigen-Specific Antitumor Immunity with Altered Peptide Ligands that Stabilize the MHC-Peptide-TCR Complex

Jill E Slansky;Frédérique M Rattis;Lisa F Boyd;Tarek Fahmy.
Immunity (2000)

349 Citations

Crystal Structure of a Lectin-Like Natural Killer Cell Receptor Bound to its Mhc Class I Ligand

José Tormo;Kannan Natarajan;David H. Margulies;Roy A. Mariuzza.
Nature (1999)

322 Citations

Determinant selection of major histocompatibility complex class I-restricted antigenic peptides is explained by class I-peptide affinity and is strongly influenced by nondominant anchor residues.

Weisan Chen;Sergei Khilko;John Fecondo;David H. Margulies.
Journal of Experimental Medicine (1994)

308 Citations

Exon shuffling: mapping polymorphic determinants on hybrid mouse transplantation antigens

Glen A. Evans;David H. Margulies;Benjamin Shykind;J. G. Seidman.
Nature (1982)

281 Citations

The TLR3 signaling complex forms by cooperative receptor dimerization

Joshua N. Leonard;Rodolfo Ghirlando;Janine Askins;Jessica K. Bell.
Proceedings of the National Academy of Sciences of the United States of America (2008)

260 Citations

Structure and expression of a mouse major histocompatibility antigen gene, H-2Ld

G A Evans;D H Margulies;R D Camerini-Otero;K Ozato.
Proceedings of the National Academy of Sciences of the United States of America (1982)

253 Citations

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National Institutes of Health

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