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Microbiology

D-Index
50
Citations
9327
World Ranking
4439
National Ranking
395

Overview

Alex J. O'Neill is affiliated with the University of Leeds in the United Kingdom. Their research primarily focuses on the field of Biochemistry, Genetics and Molecular Biology, with a total of 20 publications in this domain. Within this broad field, their work spans several subfields including Molecular Medicine, Molecular Biology, Infectious Diseases, Organic Chemistry, and Genetics.

The scientist's main research topics cover a range of areas related to bacterial resistance and molecular mechanisms. These include:

  • Antibiotic Resistance in Bacteria
  • Bacterial Genetics and Biotechnology
  • Antimicrobial Resistance in Staphylococcus
  • Veterinary Medicine and Infectious Diseases
  • RNA and Protein Synthesis Mechanisms
  • Antibiotic Use and Resistance
  • Cancer Therapeutics and Mechanisms

Alex J. O'Neill has a record of contributions to peer-reviewed journals recognized within the field of antimicrobial research. Frequent venues for their publications include the Journal of Antimicrobial Chemotherapy (6 publications), along with contributions to Nature Reviews Microbiology, Nature Communications, the Journal of Hospital Infection, and Structure.

The scientist has coauthored work with several frequent collaborators. These include Merianne Mohamad, Justin E. Clarke, Gemma C. Atkinson, Luiza H. Galarion, and Vasili Hauryliuk.

Selected recent papers by Alex J. O'Neill are as follows:

  • Target protection as a key antibiotic resistance mechanism, 2020, Nature Reviews Microbiology
  • Structural basis of ABCF-mediated resistance to pleuromutilin, lincosamide, and streptogramin A antibiotics in Gram-positive pathogens, 2021, Nature Communications
  • Selection of resistance by antimicrobial coatings in the healthcare setting, 2020, Journal of Hospital Infection
  • Structure of the 70S Ribosome from the Human Pathogen Acinetobacter baumannii in Complex with Clinically Relevant Antibiotics, 2020, Structure
  • Sal-type ABC-F proteins: intrinsic and common mediators of pleuromutilin resistance by target protection in staphylococci, 2022, Nucleic Acids Research

Best Publications

  • Targeting bacterial membrane function: an underexploited mechanism for treating persistent infections

    Julian G. Hurdle;Alex J. O'Neill;Ian Chopra;Richard E. Lee

  • Mechanistic investigation into antibacterial behaviour of suspensions of ZnO nanoparticles against E. coli

    Lingling Zhang;Yunhong Jiang;Yulong Ding;Nikolaos Daskalakis

  • Staphylococcus aureus biofilms promote horizontal transfer of antibiotic resistance

    Victoria J. Savage;Ian Chopra;Alex J. O'Neill

  • Increased mutability of Pseudomonas aeruginosa in biofilms

    K Driffield;Keith Miller;J M Bostock;A J O'Neill

  • The role of mutators in the emergence of antibiotic-resistant bacteria.

    Ian Chopra;Alexander J O’Neill;Keith Miller

  • Treatment of health-care-associated infections caused by Gram-negative bacteria: a consensus statement

    Ian Chopra;Christopher Schofield;Martin Everett;Alex O'Neill

  • Silver resistance in Gram-negative bacteria: a dissection of endogenous and exogenous mechanisms

    Christopher P. Randall;Arya Gupta;Nicole Jackson;David Busse

  • ABC-F Proteins Mediate Antibiotic Resistance through Ribosomal Protection

    Liam K. R. Sharkey;Thomas A. Edwards;Alex J. O’Neill

  • Prospects for Aminoacyl-tRNA Synthetase Inhibitors as New Antimicrobial Agents

    Julian Gregston Hurdle;Alexander John O'Neill;Ian Chopra

  • The Target of Daptomycin Is Absent from Escherichia coli and Other Gram-Negative Pathogens

    Christopher P. Randall;Katherine R. Mariner;Ian Chopra;Alex J. O'Neill

  • Exploiting current understanding of antibiotic action for discovery of new drugs.

    I. Chopra;L. Hesse;A.J. O'Neill

  • Target protection as a key antibiotic resistance mechanism

    Daniel N. Wilson;Vasili Hauryliuk;Vasili Hauryliuk;Gemma C. Atkinson;Alex J. O’Neill

  • Analysis of Mupirocin Resistance and Fitness in Staphylococcus aureus by Molecular Genetic and Structural Modeling Techniques

    Julian Gregston Hurdle;Alexander John O'Neill;Eileen Ingham;Colin Fishwick

  • Consequences of daptomycin-mediated membrane damage in Staphylococcus aureus

    Joanne Karen Hobbs;Keith Miller;Alex John O’Neill;Ian Chopra

  • Mutation frequencies for resistance to fusidic acid and rifampicin in Staphylococcus aureus

    Alex J. O'Neill;Jonathan H. Cove;Ian Chopra

  • Preclinical evaluation of novel antibacterial agents by microbiological and molecular techniques

    Alex J O’Neill;Ian Chopra

  • Molecular Genetic and Structural Modeling Studies of Staphylococcus aureus RNA Polymerase and the Fitness of Rifampin Resistance Genotypes in Relation to Clinical Prevalence

    A. J. O'Neill;T. Huovinen;C. W. G. Fishwick;I. Chopra

  • In vivo transfer of high-level mupirocin resistance from Staphylococcus epidermidis to methicillin-resistant Staphylococcus aureus associated with failure of mupirocin prophylaxis

    Julian G. Hurdle;Alex J. O'Neill;Lona Mody;Ian Chopra

  • The silver cation (Ag+): antistaphylococcal activity, mode of action and resistance studies

    Christopher P. Randall;Linda B. Oyama;Julieanne M. Bostock;Ian Chopra

  • Genetic Basis of Resistance to Fusidic Acid in Staphylococci

    A. J. O'Neill;F. McLaws;G. Kahlmeter;A. S. Henriksen

  • Antimicrobial Properties and Mode of Action of the Pyrrothine Holomycin

    Brunello Oliva;Alexander O'Neill;Jenny M. Wilson;Peter J. O'Hanlon

Frequent Co-Authors

Ian Chopra
Ian Chopra University of Leeds
Keith W. Miller
Keith W. Miller Harvard University
Jan Michiels
Jan Michiels KU Leuven
Felipe Cava
Felipe Cava Umeå University
Paul D. Fey
Paul D. Fey University of Nebraska Medical Center
James P. O'Gara
James P. O'Gara University of Galway
Aras Kadioglu
Aras Kadioglu University of Liverpool
Stanislav Gobec
Stanislav Gobec University of Ljubljana

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