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Diarmaid Hughes

Diarmaid Hughes

D-Index & Metrics

Biology and Biochemistry

D-Index
56
Citations
18466
World Ranking
14170
National Ranking
211

Overview

Diarmaid Hughes is affiliated with Uppsala University in Sweden and conducts research primarily in the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Their work spans several subfields including Molecular Medicine, Cardiology and Cardiovascular Medicine, Molecular Biology, Genetics, and Pharmacology.

The scientific interests of Diarmaid Hughes focus largely on Antibiotic Resistance in Bacteria, with additional attention to Antibiotics Pharmacokinetics and Efficacy, Bacterial Genetics and Biotechnology, Evolution and Genetic Dynamics, Cardiac Imaging and Diagnostics, Cardiovascular Function and Risk Factors, and Cancer therapeutics and mechanisms.

Frequent co-authors collaborating with Diarmaid Hughes include:

  • Sha Cao
  • Douglas L. Huseby
  • Gerrit Brandis
  • Carina Vingsbo Lundberg
  • Jon Hansen

Their recent publications illustrate a focus on bacterial infections, antimicrobial development, and evolutionary dynamics:

  • "Evaluating the potential efficacy and limitations of a phage for joint antibiotic and phage therapy of Staphylococcus aureus infections", 2021, Proceedings of the National Academy of Sciences
  • "Population Bottlenecks Strongly Influence the Evolutionary Trajectory to Fluoroquinolone Resistance in Escherichia coli", 2020, Molecular Biology and Evolution
  • "Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold-Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa", 2023, Journal of Medicinal Chemistry
  • "Model-Informed Drug Development for Antimicrobials: Translational PK and PK/PD Modeling to Predict an Efficacious Human Dose for Apramycin", 2020, Clinical Pharmacology & Therapeutics
  • "Efficacy of EBL-1003 (apramycin) against Acinetobacter baumannii lung infections in mice", 2020, Clinical Microbiology and Infection

Key venues where Diarmaid Hughes frequently publishes include:

  • Journal of Antimicrobial Chemotherapy
  • Journal of the American College of Cardiology
  • Proceedings of the National Academy of Sciences
  • Molecular Biology and Evolution
  • European Heart Journal

Best Publications

  • Antibiotic resistance and its cost: is it possible to reverse resistance?

    Dan I. Andersson;Diarmaid Hughes

  • Selection of resistant bacteria at very low antibiotic concentrations.

    Erik Gullberg;Sha Cao;Otto G. Berg;Carolina Ilbäck

  • Microbiological effects of sublethal levels of antibiotics

    Dan I. Andersson;Diarmaid Hughes

  • Mechanisms and consequences of bacterial resistance to antimicrobial peptides

    Dan I. Andersson;Diarmaid Hughes;Jessica Z. Kubicek-Sutherland

  • Effects of environment on compensatory mutations to ameliorate costs of antibiotic resistance.

    J Björkman;I Nagaev;O G Berg;Diarmaid Hughes

  • Persistence of antibiotic resistance in bacterial populations

    Dan I. Andersson;Diarmaid Hughes

  • Mutation Rate and Evolution of Fluoroquinolone Resistance in Escherichia coli Isolates from Patients with Urinary Tract Infections

    Patricia Komp Lindgren;Åsa Karlsson;Diarmaid Hughes

  • Evolution of antibiotic resistance at non-lethal drug concentrations.

    Dan I. Andersson;Diarmaid Hughes

  • Virulence of antibiotic-resistant Salmonella typhimurium

    Johanna Björkman;Diarmaid Hughes;Dan I. Andersson

  • Interplay in the selection of fluoroquinolone resistance and bacterial fitness.

    Linda L. Marcusson;Niels Frimodt-Møller;Diarmaid Hughes

  • Gene Amplification and Adaptive Evolution in Bacteria

    Dan I Andersson;Diarmaid Hughes

  • Biological cost and compensatory evolution in fusidic acid-resistant Staphylococcus aureus

    Ivan Nagaev;Johanna Björkman;Dan I Andersson;Diarmaid Hughes

  • Evolutionary consequences of drug resistance: shared principles across diverse targets and organisms

    Diarmaid Hughes;Dan I. Andersson

  • Muller's ratchet decreases fitness of a DNA-based microbe

    Dan I. Andersson;Diarmaid Hughes

  • Evolutionary Trajectories to Antibiotic Resistance

    Diarmaid Hughes;Dan I. Andersson

  • Establishment of a Superficial Skin Infection Model in Mice by Using Staphylococcus aureus and Streptococcus pyogenes

    Elisabeth Kugelberg;Tobias Norström;Thomas K. Petersen;Tore Duvold

  • Fitness‐compensatory mutations in rifampicin‐resistant RNA polymerase

    Gerrit Brandis;Marie Wrande;Lars Liljas;Diarmaid Hughes

  • Structure of a mutant EF-G reveals domain III and possibly the fusidic acid binding site.

    Martin Laurberg;Ole Kristensen;Kirill Martemyanov;Anatoly T Gudkov

  • Selection of resistance at lethal and non-lethal antibiotic concentrations

    Diarmaid Hughes;Dan I Andersson

  • Limitations of translational accuracy

    CG Kurland;Diarmaid Hughes;M. Ehrenberg

Frequent Co-Authors

Dan I. Andersson
Dan I. Andersson Uppsala University
Otto Cars
Otto Cars Uppsala University
John F. Atkins
John F. Atkins University College Cork
Niels Frimodt-Møller
Niels Frimodt-Møller University of Copenhagen
Anders Liljas
Anders Liljas Lund University
Kirill A. Martemyanov
Kirill A. Martemyanov Scripps Research Institute
Sherry L. Mowbray
Sherry L. Mowbray Uppsala University
Måns Ehrenberg
Måns Ehrenberg Uppsala University
Raymond F. Gesteland
Raymond F. Gesteland University of Utah
John R. Roth
John R. Roth University of California, Davis

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