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Immunology

D-Index
77
Citations
25984
World Ranking
1802
National Ranking
886

Overview

Youhai H. Chen is affiliated with the University of Pennsylvania in the United States and conducts research primarily in the fields of Immunology and Microbiology, Biochemistry, Genetics and Molecular Biology, and Medicine. The scientist's work spans several subfields including Immunology, Molecular Biology, Oncology, Cancer Research, and Cell Biology.

The research topics associated with Youhai H. Chen cover multiple aspects of cellular and immune mechanisms. These include:

  • Cell death mechanisms and regulation
  • Immune Cell Function and Interaction
  • Phagocytosis and Immune Regulation
  • Immune cells in cancer
  • NF-κB Signaling Pathways
  • Cancer Immunotherapy and Biomarkers
  • Immunotherapy and Immune Responses

The scientist has contributed to numerous publications, with recent notable papers including:

  • "Apoptotic cell death in disease-Current understanding of the NCCD 2023" (2023), published in Cell Death and Differentiation
  • "Stiff matrix induces exosome secretion to promote tumour growth" (2023), published in Nature Cell Biology
  • "c-Rel is a myeloid checkpoint for cancer immunotherapy" (2020), published in Nature Cancer
  • "HRS phosphorylation drives immunosuppressive exosome secretion and restricts CD8+ T-cell infiltration into tumors" (2022), published in Nature Communications
  • "CAR-Macrophages and CAR-T Cells Synergistically Kill Tumor Cells In Vitro" (2022), published in Cells

Youhai H. Chen regularly collaborates with several co-authors, including:

  • Honghong Sun
  • Xinyuan Li
  • Jason R. Goldsmith
  • Mingyue Li
  • Ali Zamani

The primary publication venues for Youhai H. Chen's work include:

  • Cells
  • The Journal of Immunology
  • Nature Cell Biology
  • Nature Communications
  • Cell Reports

The research produced by this scientist focuses on understanding complex immune regulatory processes and interactions, particularly in relation to cancer and cell death. Their work encompasses molecular pathways such as NF-κB signaling and advances in cancer immunotherapy, reflecting an integrated approach to immunological and cellular biology studies.

Best Publications

  • Exosomal PD-L1 Contributes to Immunosuppression and is Associated with anti-PD-1 Response

    Gang Chen;Alexander C. Huang;Wei Zhang;Wei Zhang;Gao Zhang

  • Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis

    Youhai Chen;Vijay K. Kuchroo;Jun-ichi Inobe;David A. Hafler

  • Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21

    Frederick J Sheedy;Eva Palsson-McDermott;Elizabeth J Hennessy;Cara Martin

  • Peripheral deletion of antigen-reactive T cells in oral tolerance.

    Youhai Chen;Jun-ichi Inobe;Reinhard Marks;Patricia Gonnella

  • COVID-19: immunopathogenesis and Immunotherapeutics.

    Li Yang;Shasha Liu;Jinyan Liu;Zhixin Zhang

  • Ferroptosis is induced following siramesine and lapatinib treatment of breast cancer cells.

    S Ma;E S Henson;Y Chen;S B Gibson

  • IL-6-Deficient Mice Are Resistant to Experimental Autoimmune Encephalomyelitis: Roles of IL-6 in the Activation and Differentiation of Autoreactive T Cells

    Elena B. Samoilova;Jennifer L. Horton;Brendan Hilliard;Tzu-Shang T. Liu

  • Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand (Trail) Is an Inhibitor of Autoimmune Inflammation and Cell Cycle Progression

    Kaimei Song;Yiguang Chen;Rüdiger Göke;Andreas Wilmen

  • Defective thymocyte apoptosis and accelerated autoimmune diseases in TRAIL −/− mice

    Salah-Eddine Lamhamedi-Cherradi;Shi-Jun Zheng;Kimberly A Maguschak;Jacques Peschon

  • TIPE2, a Negative Regulator of Innate and Adaptive Immunity that Maintains Immune Homeostasis

    Honghong Sun;Shunyou Gong;Ruaidhri J. Carmody;Anja Hilliard

  • Development of Foxp3+ Regulatory T Cells Is Driven by the c-Rel Enhanceosome

    Qingguo Ruan;Vasumathi Kameswaran;Yukiko Tone;Li Li

  • Nuclear factor-kappaB: activation and regulation during toll-like receptor signaling.

    Ruaidhrí J Carmody;Youhai H Chen

  • Oral tolerance in myelin basic protein T-cell receptor transgenic mice: suppression of autoimmune encephalomyelitis and dose-dependent induction of regulatory cells.

    Youhai Chen;J.-I. Inobe;V. K. Kuchroo;J. L. Baron

  • IL‐4 is a differentiation factor for transforming growth factor‐β secreting Th3 cells and oral administration of IL‐4 enhances oral tolerance in experimental allergic encephalomyelitis

    Jun-ichi Inobe;Anthony J. Slavin;Yoshinori Komagata;Youhai Chen

  • Negative Regulation of Toll-Like Receptor Signaling by NF-κB p50 Ubiquitination Blockade

    Ruaidhrí J. Carmody;Qingguo Ruan;Scott Palmer;Brendan Hilliard

  • The Th17 immune response is controlled by the Rel–RORγ–RORγT transcriptional axis

    Qingguo Ruan;Vasumathi Kameswaran;Yan Zhang;Shijun Zheng

  • The complement inhibitory protein DAF (CD55) suppresses T cell immunity in vivo.

    Jianuo Liu;Takashi Miwa;Brendan Hilliard;Youhai Chen

  • Induction of oral tolerance to myelin basic protein in CD8-depleted mice: both CD4+ and CD8+ cells mediate active suppression.

    Youhai Chen;J.-I. Inobe;H. L. Weiner

  • Critical roles of c-Rel in autoimmune inflammation and helper T cell differentiation

    Brendan A. Hilliard;Nicola Mason;Lingyun Xu;Jing Sun

  • Amelioration of collagen-induced arthritis by CD95 (Apo-1/Fas)-ligand gene transfer.

    Haidi Zhang;Yiping Yang;Jennifer L. Horton;Elena B. Samoilova

  • Roles of TNF-Related Apoptosis-Inducing Ligand in Experimental Autoimmune Encephalomyelitis

    Brendan Hilliard;Andreas Wilmen;Cheryl Seidel;Tzu-Shang T. Liu

Frequent Co-Authors

Xiaochun Wan
Xiaochun Wan Anhui Agricultural University
Howard L. Weiner
Howard L. Weiner Harvard University
Wafik S. El-Deiry
Wafik S. El-Deiry Brown University
Vijay K. Kuchroo
Vijay K. Kuchroo Harvard University
Alan Bridge
Alan Bridge Swiss Institute of Bioinformatics
Elisabeth Gasteiger
Elisabeth Gasteiger Swiss Institute of Bioinformatics
Xiaolu Yang
Xiaolu Yang University of Pennsylvania
Ramachandran Murali
Ramachandran Murali Cedars-Sinai Medical Center
Rolf Apweiler
Rolf Apweiler European Bioinformatics Institute
James M. Wilson
James M. Wilson University of Pennsylvania

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Related Online Degrees & Career Pathways

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