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Biology and Biochemistry

D-Index
50
Citations
8124
World Ranking
17717
National Ranking
7260

Overview

Ramachandran Murali is affiliated with Cedars-Sinai Medical Center in the United States. Their research spans multiple disciplines within the biological and medical sciences, with a significant focus on molecular biology and oncology.

Their publication record includes papers in high-impact journals and covers diverse topics from cancer immunotherapy to cardiac remodeling. Notable recent publications include:

  • iPSC modeling of young-onset Parkinson's disease reveals a molecular signature of disease and novel therapeutic candidates, 2020, Nature Medicine
  • c-Rel is a myeloid checkpoint for cancer immunotherapy, 2020, Nature Cancer
  • Receptor-interacting protein kinase 2 (RIPK2) stabilizes c-Myc and is a therapeutic target in prostate cancer metastasis, 2022, Nature Communications
  • Neuropilin 1 regulates bone marrow vascular regeneration and hematopoietic reconstitution, 2021, Nature Communications
  • Asporin, an extracellular matrix protein, is a beneficial regulator of cardiac remodeling, 2022, Matrix Biology

The scientist frequently collaborates with a number of colleagues, including Avradip Chatterjee, Madhusudhanarao Katiki, Michael R. Freeman, Qian Chen, and John S. Yu. These collaborations have yielded multiple coauthored publications.

Ramachandran Murali's primary fields of study are Biochemistry, Genetics and Molecular Biology, and Medicine, with subfields focused on Molecular Biology, Oncology, Immunology, Pulmonary and Respiratory Medicine, and Radiology, Nuclear Medicine and Imaging.

Their research covers several main topics, including:

  • Monoclonal and Polyclonal Antibodies Research
  • Prostate Cancer Treatment and Research
  • Ubiquitin and proteasome pathways
  • Immune cells in cancer
  • Cancer-related gene regulation
  • Epigenetics and DNA Methylation
  • Protein Tyrosine Phosphatases

Ramachandran Murali has published extensively in journals such as Nature Communications, bioRxiv (Cold Spring Harbor Laboratory), Monoclonal Antibodies in Immunodiagnosis and Immunotherapy, Cancer Research, and Journal of Biological Chemistry.

Best Publications

  • ErbB receptors: from oncogenes to targeted cancer therapies

    Hongtao Zhang;Alan Berezov;Qiang Wang;Geng Zhang

  • Alternatively activated macrophages promote pancreatic fibrosis in chronic pancreatitis.

    Jing Xue;Vishal Sharma;Michael H. Hsieh;Ajay Chawla

  • Rationally designed anti-HER2/neu peptide mimetic disables P185HER2/neu tyrosine kinases in vitro and in vivo.

    Byeong Woo Park;Hong Tao Zhang;Chuanjin Wu;Alan Berezov

  • HER2/Neu: mechanisms of dimerization/oligomerization

    Patrick J Brennan;Toru Kumagai;Alan Berezov;Ramachandran Murali

  • Polymersomes: A new multi-functional tool for cancer diagnosis and therapy

    Dalia Hope Levine;P. Peter Ghoroghchian;Jaclyn Freudenberg;Geng Zhang

  • Role of tryptophan repeats and flanking amino acids in Myb-DNA interactions.

    Pothana Saikumar;Ramachandran Murali;E. Premkumar Reddy

  • Structure–based design and characterization of exocyclic peptidomimetics that inhibit TNFα binding to its receptor

    Wataru Takasaki;Yuri Kajino;Kiichi Kajino;Ramachandran Murali

  • The refined crystal structure of hexon, the major coat protein of adenovirus type 2, at 2.9 A resolution.

    F. K. Athappilly;R. Murali;J. J. Rux;Zhaoping Cai

  • Stearoyl-CoA Desaturase Promotes Liver Fibrosis and Tumor Development in Mice via a Wnt Positive-Signaling Loop by Stabilization of Low-Density Lipoprotein-Receptor-Related Proteins 5 and 6

    Keane K.Y. Lai;Soo Mi Kweon;Feng Chi;Edward Hwang

  • A TNF receptor loop peptide mimic blocks RANK ligand-induced signaling, bone resorption, and bone loss

    Kazuhiro Aoki;Hiroaki Saito;Cecile Itzstein;Masaji Ishiguro

  • Structure of Sad1-UNC84 Homology (SUN) Domain Defines Features of Molecular Bridge in Nuclear Envelope

    Zhaocai Zhou;Zhaocai Zhou;Xiulian Du;Zheng Cai;Xiaomin Song

  • Therapeutic peptides and peptidomimetics.

    Thomas Kieber-Emmons;Ramachandran Murali;Mark I Greene

  • ONECUT2 is a targetable master regulator of lethal prostate cancer that suppresses the androgen axis.

    Mirja Rotinen;Sungyong You;Julie Yang;Simon G Coetzee

  • Disabling erbB receptors with rationally designed exocyclic mimetics of antibodies: structure-function analysis.

    Alan Berezov;Hong-Tao Zhang;Mark I. Greene;Ramachandran Murali

  • Arginine at positions 13 or 70-71 in pocket 4 of HLA-DRB1 alleles is associated with susceptibility to tuberculoid leprosy.

    L. Zerva;B. Cizman;N. K. Mehra;S. K. Alahari

  • Disabling receptor ensembles with rationally designed interface peptidomimetics.

    Alan Berezov;Jinqiu Chen;Qingdu Liu;Hong-Tao Zhang

  • iPSC modeling of young-onset Parkinson's disease reveals a molecular signature of disease and novel therapeutic candidates.

    A. H. Laperle;S. Sances;N. Yucer;V. J. Dardov

  • Compositions and methods of treating tumors

    Mark I. Greene;Donald M. O'Rourke;Ramachandran Murali;Byeong Woo Park

  • Acute pesticide poisoning: 15 years experience of a large North-West Indian hospital

    R Murali;Ashish Bhalla;Dalbir Singh;Surjit Singh

  • The TNF receptor superfamily: role in immune inflammation and bone formation.

    Xin Cheng;Masa Kinosaki;Ramachandran Murali;Mark I Greene

Frequent Co-Authors

Mark I. Greene
Mark I. Greene University of Pennsylvania
Hongtao Zhang
Hongtao Zhang University of Pennsylvania
Thomas Kieber-Emmons
Thomas Kieber-Emmons University of Arkansas for Medical Sciences
Stephen J. Pandol
Stephen J. Pandol Cedars-Sinai Medical Center
Kazuhiro Aoki
Kazuhiro Aoki National Institutes of Natural Sciences
Bin Li
Bin Li Shanghai Jiao Tong University
Michael R. Freeman
Michael R. Freeman Cedars-Sinai Medical Center
Hidekazu Tsukamoto
Hidekazu Tsukamoto University of Southern California
Beatrice S. Knudsen
Beatrice S. Knudsen University of Utah
Youhai H. Chen
Youhai H. Chen University of Pennsylvania

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