World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
59
Citations
18229
World Ranking
12307
National Ranking
5268

Overview

Xiaolu Yang is affiliated with the University of Pennsylvania in the United States and conducts research primarily in the fields of Biochemistry, Genetics and Molecular Biology, as well as Medicine. Their work focuses on several subfields including Molecular Biology, Cell Biology, Immunology, Epidemiology, and Cancer Research.

The scientific topics that Xiaolu Yang addresses encompass Endoplasmic Reticulum Stress and Disease, Autophagy in Disease and Therapy, Ubiquitin and proteasome pathways, interferon and immune responses, Cancer, Hypoxia, and Metabolism, Neonatal Health and Biochemistry, and RNA regulation and disease.

Yang's recent publications span prestigious journals and reflect a range of molecular and cellular studies. Examples include:

  • TRIM25 promotes the cell survival and growth of hepatocellular carcinoma through targeting Keap1-Nrf2 pathway, 2020, Nature Communications
  • Chaperone-mediated autophagy regulates the pluripotency of embryonic stem cells, 2020, Science
  • Upregulation of Antioxidant Capacity and Nucleotide Precursor Availability Suffices for Oncogenic Transformation, 2020, Cell Metabolism
  • DAXX represents a new type of protein-folding enabler, 2021, Nature
  • TRIM15 and CYLD regulate ERK activation via lysine-63-linked polyubiquitination, 2021, Nature Cell Biology

Frequent co-authors collaborating with Xiaolu Yang include Yi Xu, Guixin Zhu, Y Zhang, Sixiang Yu, and Joshua D. Rabinowitz. These collaborations likely contribute to the multidisciplinary approach reflected in Yang's research output.

Yang has published multiple papers in prominent venues such as Science, Cell Reports, Proceedings of the National Academy of Sciences, Nature Communications, and Cell Metabolism. The range of publication venues indicates engagement with a broad but focused scientific community in molecular and cellular biology and related biomedical sciences.

Best Publications

  • Daxx, a novel fas-binding protein that activates jnk and apoptosis

    Xiaolu Yang;Roya Khosravi-Far;Howard Y. Chang;David Baltimore

  • Proteases for Cell Suicide: Functions and Regulation of Caspases

    Howard Y. Chang;Xiaolu Yang

  • Activation of noncanonical NF-κB requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2, TRAF3 and the kinase NIK

    Brian J Zarnegar;Yaya Wang;Douglas J Mahoney;Paul W Dempsey

  • p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase

    Peng Jiang;Wenjing Du;Wenjing Du;Xingwu Wang;Anthony Mancuso

  • Activation of Apoptosis Signal-Regulating Kinase 1 (ASK1) by the Adapter Protein Daxx

    Howard Y. Chang;Hideki Nishitoh;Xiaolu Yang;Hidenori Ichijo

  • c-FLIPL is a dual function regulator for caspase-8 activation and CD95-mediated apoptosis

    David W. Chang;Zheng Xing;Zheng Xing;Yi Pan;Alicia Algeciras-Schimnich

  • TCF-1-Centered Transcriptional Network Drives an Effector Versus Exhausted CD8 T Cell-Fate Decision

    Zeyu Chen;Zhicheng Ji;Shin Foong Ngiow;Sasikanth Manne

  • Proteogenomic and metabolomic characterization of human glioblastoma

    Liang-Bo Wang;Alla Karpova;Marina A. Gritsenko;Jennifer E. Kyle

  • Autoproteolytic Activation of Pro-Caspases by Oligomerization

    Xiaolu Yang;Howard Y Chang;David Baltimore

  • The Human Tumor Atlas Network: Charting Tumor Transitions Across Space and Time at Single-Cell Resolution

    Orit Rozenblatt-Rosen;Aviv Regev;Aviv Regev;Aviv Regev;Philipp Oberdoerffer;Tal Nawy

  • Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence

    Peng Jiang;Wenjing Du;Anthony Mancuso;Kathryn E. Wellen

  • Yeast SNF1 is functionally related to mammalian AMP-activated protein kinase and regulates acetyl-CoA carboxylase in vivo

    A. Woods;M. R. Munday;J. Scott;Xiaolu Yang

  • TIPE2, a Negative Regulator of Innate and Adaptive Immunity that Maintains Immune Homeostasis

    Honghong Sun;Shunyou Gong;Ruaidhri J. Carmody;Anja Hilliard

  • Essential Role of CED-4 Oligomerization in CED-3 Activation and Apoptosis

    Xiaolu Yang;Howard Y. Chang;David Baltimore

  • The lncRNA Neat1 promotes activation of inflammasomes in macrophages.

    Pengfei Zhang;Limian Cao;Rongbin Zhou;Xiaolu Yang

  • Interdimer processing mechanism of procaspase-8 activation

    David W. Chang;Zheng Xing;Vanessa L. Capacio;Marcus E. Peter

  • A protein kinase substrate identified by the two-hybrid system

    Xiaolu Yang;E. J. A. Hubbard;M. Carlson

  • Cellular Inhibitor of Apoptosis 1 and 2 Are Ubiquitin Ligases for the Apoptosis Inducer Smac/DIABLO

    Shimin Hu;Xiaolu Yang

  • Critical role for Daxx in regulating Mdm2

    Jun Tang;Li-Ke Qu;Jianke Zhang;Wenge Wang

  • TAp73 enhances the pentose phosphate pathway and supports cell proliferation

    Wenjing Du;Peng Jiang;Peng Jiang;Anthony Mancuso;Aaron Stonestrom

Frequent Co-Authors

Howard Y. Chang
Howard Y. Chang Amgen (United States)
Marian Carlson
Marian Carlson Howard Hughes Medical Institute
David Baltimore
David Baltimore California Institute of Technology
Mian Wu
Mian Wu University of Science and Technology of China
Xiaochun Wan
Xiaochun Wan Anhui Agricultural University
David W. Chang
David W. Chang University of Chicago
Youhai H. Chen
Youhai H. Chen University of Pennsylvania
James Shorter
James Shorter University of Pennsylvania
Ian A. Blair
Ian A. Blair University of Pennsylvania
James L. Riley
James L. Riley University of Pennsylvania

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