World's Best Scientists 2026 revealed!

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Molecular Biology

D-Index
88
Citations
24930
World Ranking
786
National Ranking
418

Medicine

D-Index
91
Citations
27067
World Ranking
11853
National Ranking
6080

Research.com Recognitions

  • 2010 - Robert J. and Claire Pasarow Foundation Medical Research Award
  • 2008 - Distinguished Scientist Award, American Heart Association
  • 2007 - Member of the National Academy of Sciences
  • 2005 - Fellow of the American Academy of Arts and Sciences
  • 2001 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 1999 - Member of the National Academy of Medicine (NAM)
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

David Ginsburg is affiliated with the University of Michigan-Ann Arbor in the United States. Their research spans several interconnected fields within biochemistry, genetics, molecular biology, and medicine. The main areas of study for David Ginsburg include hematology, molecular biology, cell biology, immunology, and surgery.

The scientist's work has emphasized key topics, including:

  • Cellular transport and secretion
  • Blood coagulation and thrombosis mechanisms
  • Protease and inhibitor mechanisms
  • Endoplasmic reticulum stress and disease
  • Platelet disorders and treatments
  • Cholesterol and lipid metabolism
  • Erythrocyte function and pathophysiology

David Ginsburg has contributed to publications in various venues with repeated appearances in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Clinical Investigation
  • Blood
  • Scientific Reports
  • Blood Advances

Frequent collaborators include Vi T. Tang, David Siemieniak, Brian T. Emmer, Laura M. Haynes, and Rami Khoriaty, indicating ongoing research partnerships across multiple projects.

Selected recent papers illustrate the range and focus of Ginsburg's research:

  • Whole-exome sequencing identifies rare variants in STAB2 associated with venous thromboembolic disease, 2020, Blood
  • Cargo selection in endoplasmic reticulum-to-Golgi transport and relevant diseases, 2023, Journal of Clinical Investigation
  • Genome-scale CRISPR screening for modifiers of cellular LDL uptake, 2021, PLoS Genetics
  • Hepatic inactivation of murine Surf4 results in marked reduction in plasma cholesterol, 2022, eLife
  • The small GTPase RAB10 regulates endosomal recycling of the LDL receptor and transferrin receptor in hepatocytes, 2022, Journal of Lipid Research

David Ginsburg has been recognized with several awards and honors, including:

  • Robert J. and Claire Pasarow Foundation Medical Research Award (2010)
  • Distinguished Scientist Award, American Heart Association (2008)
  • Member of the National Academy of Sciences (2007)
  • Fellow of the American Academy of Arts and Sciences (2005)
  • Fellow of the American Association for the Advancement of Science (AAAS) (2001)
  • Member of the National Academy of Medicine (1999)
  • Member of the Association of American Physicians

Best Publications

  • Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura

    Gallia G. Levy;William C. Nichols;Eric C. Lian;Tatiana Foroud

  • Bleomycin-induced pulmonary fibrosis in transgenic mice that either lack or overexpress the murine plasminogen activator inhibitor-1 gene.

    Daniel T. Eitzman;Ronald D. McCoy;Xianxian Zheng;William P. Fay

  • Detectable clonal mosaicism from birth to old age and its relationship to cancer.

    Cathy C. Laurie;Cecelia A Laurie;Kenneth Rice;Kimberly F. Doheny

  • Impact, Diagnosis and Treatment of von Willebrand Disease*

    J E Sadler;P M Mannucci;Erik Berntorp;N Bochkov

  • Genome-wide mapping of DNase hypersensitive sites using massively parallel signature sequencing (MPSS)

    Gregory E. Crawford;Ingeborg E. Holt;James Whittle;Bryn D. Webb

  • Human von Willebrand factor (vWF): isolation of complementary DNA (cDNA) clones and chromosomal localization

    David Ginsburg;David Ginsburg;Robert I. Handin;Robert I. Handin;David T. Bonthron;Timothy A. Donlon;Timothy A. Donlon

  • Mutations in the ER–Golgi Intermediate Compartment Protein ERGIC-53 Cause Combined Deficiency of Coagulation Factors V and VIII

    William C. Nichols;Uri Seligsohn;Ariella Zivelin;Valeri H. Terry

  • Plasminogen Is a Critical Host Pathogenicity Factor for Group A Streptococcal Infection

    Hongmin Sun;Ulrika Ringdahl;Jonathon W. Homeister;William P. Fay

  • cDNA cloning of human plasminogen activator-inhibitor from endothelial cells

    D Ginsburg;R Zeheb;A Y Yang;U M Rafferty

  • von Willebrand disease.

    William C. Nichols;David Ginsburg

  • Cultured human endothelial cells express platelet-derived growth factor B chain: cDNA cloning and structural analysis

    Tucker Collins;David Ginsburg;Jeremy M. Boss;Stuart H. Orkin

  • Brief report: complete deficiency of plasminogen-activator inhibitor type 1 due to a frame-shift mutation.

    William P. Fay;Amy D. Shapiro;Judy L. Shih;Raymond R. Schleef

  • Shigatoxin triggers thrombotic thrombocytopenic purpura in genetically susceptible ADAMTS13-deficient mice.

    David G. Motto;Anil K. Chauhan;Guojing Zhu;Jonathon Homeister

  • Localization of the gene for familial primary pulmonary hypertension to chromosome 2q31–32

    William C. Nichols;Daniel L. Koller;Bonnie Slovis;Tatiana Foroud

  • Plasminogen activator inhibitor-1 regulates tumor growth and angiogenesis.

    Grainne A. McMahon;Eric Petitclerc;Steingrimur Stefansson;Elizabeth Smith

  • Bleeding due to disruption of a cargo-specific ER-to-Golgi transport complex.

    Bin Zhang;Michael A. Cunningham;William C. Nichols;John A. Bernat

  • Impaired intracellular transport produced by a subset of type IIA von Willebrand disease mutations.

    S. E. Lyons;M. E Bruck;E. J. W. Bowie;D. Ginsburg

  • Fatal haemorrhage and incomplete block to embryogenesis in mice lacking coagulation factor V.

    Cui J;O'Shea Ks;Purkayastha A;Saunders Tl

  • Serpin-Protease Complexes Are Trapped as Stable Acyl-Enzyme Intermediates

    Daniel A. Lawrence;David Ginsburg;Duane E. Day;Mitchell B. Berkenpas

  • Shigatoxin Triggers Thrombotic Thrombocytopenic Purpura in Genetically Susceptible ADAMTS13-Deficient Mice.

    David G. Motto;Anil K. Chauhan;Guojing Zhu;Jonathon Homeister

Frequent Co-Authors

Randal J. Kaufman
Randal J. Kaufman Sanford Burnham Prebys Medical Discovery Institute
Daniel A. Lawrence
Daniel A. Lawrence University of Michigan–Ann Arbor
Jun Li
Jun Li University of Oklahoma Health Sciences Center
Stuart H. Orkin
Stuart H. Orkin Harvard University
Joseph H. Antin
Joseph H. Antin Dana-Farber Cancer Institute
Thomas L. Saunders
Thomas L. Saunders University of Michigan–Ann Arbor
Denisa D. Wagner
Denisa D. Wagner Boston Children's Hospital
Anne-Claude Gingras
Anne-Claude Gingras Lunenfeld-Tanenbaum Research Institute
Ivan Maillard
Ivan Maillard University of Pennsylvania
Francis S. Collins
Francis S. Collins National Institutes of Health

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