World's Best Scientists 2026 revealed!
Karen Vanhoorelbeke

Karen Vanhoorelbeke

D-Index & Metrics

Biology and Biochemistry

D-Index
55
Citations
10323
World Ranking
15111
National Ranking
264

Overview

Karen Vanhoorelbeke is affiliated with KU Leuven in Belgium and has contributed extensively to the fields of Medicine and Immunology and Microbiology. Their research spans multiple subfields including Immunology, Hematology, Genetics, Infectious Diseases, and Radiology, Nuclear Medicine and Imaging.

The scientist's work focuses on several key topics, including:

  • Complement system in diseases
  • Platelet Disorders and Treatments
  • Coagulation, Bradykinin, Polyphosphates, and Angioedema
  • Monoclonal and Polyclonal Antibodies Research
  • Renal Diseases and Glomerulopathies
  • Blood groups and transfusion
  • Mechanical Circulatory Support Devices

Vanhoorelbeke has authored numerous papers published in well-regarded journals, among which the most cited recent works include:

  • Open ADAMTS13, induced by antibodies, is a biomarker for subclinical immune-mediated thrombotic thrombocytopenic purpura (2020, Blood)
  • First report of a de novo iTTP episode associated with an mRNA-based anti-COVID-19 vaccination (2021, Journal of Thrombosis and Haemostasis)
  • Crystal structure of ADAMTS13 CUB domains reveals their role in global latency (2021, Science Advances)
  • Thrombus formation during ECMO: Insights from a detailed histological analysis of thrombus composition (2022, Journal of Thrombosis and Haemostasis)
  • Imbalance of von Willebrand factor and ADAMTS13 axis is rather a biomarker of strong inflammation and endothelial damage than a cause of thrombotic process in critically ill COVID-19 patients (2021, Journal of Thrombosis and Haemostasis)

The scientist has frequently published in journals such as the Journal of Thrombosis and Haemostasis, Research and Practice in Thrombosis and Haemostasis, Blood Advances, Blood, and Haematologica, indicating a focus on hematological and thrombosis-related research contexts.

Vanhoorelbeke collaborates regularly with several coauthors, including Simon F. De Meyer, Claudia Tersteeg, Paul Coppo, Bérangère S. Joly, and Agnès Veyradier, reflecting a collaborative research network within related biomedical disciplines.

Best Publications

  • Platelets at work in primary hemostasis.

    Kathleen Broos;Hendrik B. Feys;Simon F. De Meyer;Karen Vanhoorelbeke

  • Mechanisms of Autoantibody-Induced Pathology.

    Ralf J. Ludwig;Karen Vanhoorelbeke;Frank Leypoldt;Ziya Kaya

  • Neutrophil extracellular traps in ischemic stroke thrombi.

    Elodie Laridan;Frederik Denorme;Linda Desender;Olivier François

  • Thrombotic thrombocytopenic purpura

    Johanna Anna Kremer Hovinga;Paul Coppo;Bernhard Lämmle;Joel L Moake

  • ADAMTS13 and anti-ADAMTS13 antibodies as markers for recurrence of acquired thrombotic thrombocytopenic purpura during remission

    Flora Peyvandi;Silvia Lavoretano;Roberta Palla;Hendrik B. Feys

  • von Willebrand factor to the rescue.

    Simon F. De Meyer;Hans Deckmyn;Karen Vanhoorelbeke

  • Deficiency of von Willebrand factor protects mice from ischemic stroke

    Christoph Kleinschnitz;Simon F. De Meyer;Tobias Schwarz;Madeleine Austinat

  • ADAMTS13 activity to antigen ratio in physiological and pathological conditions associated with an increased risk of thrombosis

    Hendrik B. Feys;Maria T. Canciani;Flora Peyvandi;Hans Deckmyn

  • Shielding of the A1 Domain by the D′D3 Domains of von Willebrand Factor Modulates Its Interaction with Platelet Glycoprotein Ib-IX-V *

    Hans Ulrichts;Miklós Udvardy;Peter J. Lenting;Inge Pareyn

  • Unwinding the von Willebrand factor strings puzzle.

    Karen De Ceunynck;Simon F. De Meyer;Karen Vanhoorelbeke

  • Inhibition of the von Willebrand (VWF)–collagen interaction by an antihuman VWF monoclonal antibody results in abolition of in vivo arterial platelet thrombus formation in baboons

    Dongmei Wu;Karen Vanhoorelbeke;Nancy Cauwenberghs;Muriel Meiring

  • Decreased ADAMTS-13 (A disintegrin-like and metalloprotease with thrombospondin type 1 repeats) is associated with a poor prognosis in sepsis-induced organ failure.

    Kenneth Martin;Delphine Borgel;Nicolas Lerolle;Hendrik B. Feys

  • Anfibatide, a novel GPIb complex antagonist, inhibits platelet adhesion and thrombus formation in vitro and in vivo in murine models of thrombosis

    Xi Lei;Adili Reheman;Yan Hou;Hui Zhou

  • Allosteric activation of ADAMTS13 by von Willebrand factor

    Joshua Muia;Jian Zhu;Garima Gupta;Sandra L. Haberichter

  • Principal role of glycoprotein VI in alpha2beta1 and alphaIIbbeta3 activation during collagen-induced thrombus formation.

    Christelle Lecut;Anne Schoolmeester;Marijke J.E. Kuijpers;Jos L.V. Broers

  • Conformational activation of ADAMTS13

    Kieron South;Brenda M. Luken;James T. B. Crawley;Rebecca Phillips

  • Preemptive rituximab prevents long-term relapses in immune-mediated thrombotic thrombocytopenic purpura.

    Matthieu Jestin;Ygal Benhamou;An-Sofie Schelpe;Elien Roose

  • Platelet adhesion to dimeric beta-glycoprotein I under conditions of flow is mediated by at least two receptors: glycoprotein Ibalpha and apolipoprotein E receptor 2'.

    M. T. T Pennings;R. H. W. M Derksen;M Van Lummel;J Adelmeijer

  • Thrombotic thrombocytopenic purpura directly linked with ADAMTS13 inhibition in the baboon (Papio ursinus)

    Hendrik B. Feys;Jan Roodt;Nele Vandeputte;Inge Pareyn

  • Inherited traits affecting platelet function

    Isabelle I. Salles;Hendrik B. Feys;Brecht F. Iserbyt;Simon F. De Meyer

Frequent Co-Authors

Jan Voorberg
Jan Voorberg University of Amsterdam
Johan Hofkens
Johan Hofkens KU Leuven
Flora Peyvandi
Flora Peyvandi University of Milan
G. Kaplanski
G. Kaplanski Hôpital de la Conception
Hiroshi Uji-i
Hiroshi Uji-i KU Leuven
Paul Declerck
Paul Declerck KU Leuven
Peter J. Lenting
Peter J. Lenting University of Paris-Saclay
Bernhard Lämmle
Bernhard Lämmle University of Bern

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