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Immunology

D-Index
46
Citations
11489
World Ranking
4577
National Ranking
216

Overview

G. Kaplanski is affiliated with Hôpital de la Conception in France and has an extensive publication record in medicine, with a focus on immunology, infectious diseases, genetics, rheumatology, and pulmonary and respiratory medicine. Their research encompasses a broad range of topics related to inflammatory and autoimmune responses, particularly in the context of COVID-19 and related systemic conditions.

Their recent research contributions include papers such as:

  • Early IL-1 receptor blockade in severe inflammatory respiratory failure complicating COVID-19, 2020, Proceedings of the National Academy of Sciences
  • Effect of anakinra on mortality in patients with COVID-19: a systematic review and patient-level meta-analysis, 2021, The Lancet Rheumatology
  • Dissemination of extreme levels of extracellular vesicles: tissue factor activity in patients with severe COVID-19, 2021, Blood Advances
  • Circulating Endothelial Cells as a Marker of Endothelial Injury in Severe COVID-19, 2020, The Journal of Infectious Diseases
  • Functional and genetic testing in adults with HLH reveals an inflammatory profile rather than a cytotoxicity defect, 2020, Blood

Kaplanski's frequent coauthors include Raphaël Cauchois, Pierre-André Jarrot, Edwige Tellier, A. Benyamine, and N. Schleinitz, indicating active collaboration within a network of researchers focusing on related immunological and inflammatory conditions.

Their work has been published multiple times in several specialist journals and venues, notably:

  • La Revue de Médecine Interne
  • Journal of Thrombosis and Haemostasis
  • Blood
  • Lara D. Veeken
  • Research and Practice in Thrombosis and Haemostasis

In addition to journal articles, Kaplanski has contributed to book publications, including a 2023 release titled Inflammation in the Pathogenesis of COVID-19 published by Frontiers Media.

The main topics of their research work cover:

  • COVID-19 Clinical Research Studies
  • Complement system in diseases
  • Coagulation, Bradykinin, Polyphosphates, and Angioedema
  • Vasculitis and related conditions
  • Long-Term Effects of COVID-19
  • Systemic Lupus Erythematosus Research
  • Autoimmune and Inflammatory Disorders Research

This profile reflects a research career dedicated to the investigation of severe inflammatory mechanisms, immune system dysfunction, and the vascular and coagulation complications arising in infectious and autoimmune diseases.

Best Publications

  • Interleukin-18 and IL-18 binding protein.

    Charles A. Dinarello;Daniela Novick;Soohyun Kim;Soohyun Kim;Gilles Kaplanski

  • IL-6: a regulator of the transition from neutrophil to monocyte recruitment during inflammation

    Gilles Kaplanski;Valérie Marin;Félix Montero-Julian;Alberto Mantovani

  • Interleukin-18: Biological properties and role in disease pathogenesis

    Gilles Kaplanski

  • Endothelium structure and function in kidney health and disease

    Noemie Jourde-Chiche;Noemie Jourde-Chiche;Fadi Fakhouri;Laetitia Dou;Jeremy Bellien

  • Modular Transcriptional Repertoire Analyses of Adults With Systemic Lupus Erythematosus Reveal Distinct Type I and Type II Interferon Signatures

    Laurent Chiche;Noémie Jourde-Chiche;Elizabeth Whalen;Scott Presnell

  • IL-18 induces PD-1-dependent immunosuppression in cancer.

    Magali Terme;Evelyn Ullrich;Laetitia Aymeric;Kathrin Meinhardt

  • Severe imbalance of IL-18/IL-18BP in patients with secondary hemophagocytic syndrome

    Karin Mazodier;Valérie Marin;Daniela Novick;Catherine Farnarier

  • Efficiency of curative and prophylactic treatment with rituximab in ADAMTS13-deficient thrombotic thrombocytopenic purpura: a study of 11 cases

    Fadi Fakhouri;Jean Paul Vernant;Agnès Veyradier;Martine Wolf

  • Interleukin-18, more than a Th1 cytokine

    Daniela Novick;Soohyun Kim;Gilles Kaplanski;Charles A. Dinarello

  • Thrombin-Activated Human Endothelial Cells Support Monocyte Adhesion In Vitro Following Expression of Intercellular Adhesion Molecule-1 (ICAM-1; CD54) and Vascular Cell Adhesion Molecule-1 (VCAM-1; CD106)

    Gilles Kaplanski;Valérie Marin;Martine Fabrigoule;Vera Boulay

  • The IL-6-Soluble IL-6Rα Autocrine Loop of Endothelial Activation as an Intermediate Between Acute and Chronic Inflammation: an Experimental Model Involving Thrombin

    Valérie Marin;Felix A. Montero-Julian;Sandra Grès;Vera Boulay

  • Endothelial cell culture: protocol to obtain and cultivate human umbilical endothelial cells.

    Valérie Marin;Gilles Kaplanski;Sandra Grès;Catherine Farnarier

  • Sterile inflammation of endothelial cell-derived apoptotic bodies is mediated by interleukin-1α

    Yaël Berda-Haddad;Stéphane Robert;Paul Salers;Leila Zekraoui

  • Interleukin-1 induces interleukin-8 secretion from endothelial cells by a juxtacrine mechanism

    Gilles Kaplanski;Catherine Farnarier;Solange Kaplanski;Reuven Porat

  • Intravenous endotoxin suppresses the cytokine response of peripheral blood mononuclear cells of healthy humans.

    E. V. Granowitz;R. Porat;J. W. Mier;S. F. Orencole

  • Granulocyte-endothelium initial adhesion : analysis of transient binding events mediated by E-selectin in a laminar shear flow

    G. Kaplanski;C. Farnarier;O. Tissot;A. Pierres

  • Early IL-1 receptor blockade in severe inflammatory respiratory failure complicating COVID-19.

    Raphaël Cauchois;Marie Koubi;David Delarbre;Cécile Manet

  • Hydroxychloroquine in systemic lupus erythematosus: results of a French multicentre controlled trial (PLUS Study)

    Nathalie Costedoat-Chalumeau;Lionel Galicier;Lionel Galicier;Olivier Aumaître;Camille Francès

  • Thrombin induces endothelial type II activation in vitro: IL-1 and TNF-alpha-independent IL-8 secretion and E-selectin expression.

    G Kaplanski;M Fabrigoule;V Boulay;C A Dinarello

  • IL-6 and IL-8 production from cultured human endothelial cells stimulated by infection with Rickettsia conorii via a cell-associated IL-1 alpha-dependent pathway.

    G Kaplanski;N Teysseire;C Farnarier;S Kaplanski

  • Activated platelets induce endothelial secretion of interleukin-8 in vitro via an interleukin-1-mediated event

    Gilles Kaplanski;Reuven Porat;Koichi Aiura;John K. Erban

  • Interleukin-1 Receptor Blockade Reduces the Number and Size of Murine B16 Melanoma Hepatic Metastases

    Fernando Vidal-Vanaclocha;Cristian Amézaga;Aintzane Asumendi;Gilles Kaplanski

  • Uveitis: Diagnostic work-up. A literature review and recommendations from an expert committee.

    Pascal Sève;Patrice Cacoub;Bahram Bodaghi;Salim Trad

  • Effect of anakinra on mortality in patients with COVID-19: a systematic review and patient-level meta-analysis.

    Evdoxia Kyriazopoulou;Thomas Huet;Giulio Cavalli;Andrea Gori;Andrea Gori;Andrea Gori

Frequent Co-Authors

Patrice Cacoub
Patrice Cacoub Sorbonne University
Françoise Dignat-George
Françoise Dignat-George Aix-Marseille University
Pierre Bongrand
Pierre Bongrand Aix-Marseille University
Charles A. Dinarello
Charles A. Dinarello University of Colorado Anschutz Medical Campus
David Saadoun
David Saadoun Université Paris Cité
Pascale Paul
Pascale Paul Aix-Marseille University
Dominique Figarella-Branger
Dominique Figarella-Branger Aix-Marseille University
Andrea Gori
Andrea Gori University of Milan
Daniela Novick
Daniela Novick Weizmann Institute of Science

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