D-Index & Metrics Best Publications

D-Index & Metrics

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Immunology D-index 55 Citations 9,651 80 World Ranking 2215 National Ranking 96

Overview

What is she best known for?

The fields of study she is best known for:

  • Gene
  • Mutation
  • Genetics

Geneviève de Saint Basile mainly focuses on Immunology, Cell biology, Exocytosis, Hematopoietic stem cell transplantation and Degranulation. The various areas that Geneviève de Saint Basile examines in her Immunology study include Mutation and Histopathology. In her study, which falls under the umbrella issue of Cell biology, Cell killing, Lymphocyte and Cell Degranulation is strongly linked to Immunological synapse.

She has included themes like Survival rate, Gastroenterology, Single Center, Familial Hemophagocytic Lymphohistiocytosis and Severe combined immunodeficiency in her Hematopoietic stem cell transplantation study. Geneviève de Saint Basile works mostly in the field of Single Center, limiting it down to topics relating to Hemophagocytosis and, in certain cases, Hemophagocytic lymphohistiocytosis. Her studies in Degranulation integrate themes in fields like Granule, Lymphokine-activated killer cell and Effector.

Her most cited work include:

  • Munc13-4 Is Essential for Cytolytic Granules Fusion and Is Mutated in a Form of Familial Hemophagocytic Lymphohistiocytosis (FHL3) (743 citations)
  • CD40-CD40L independent Ig gene hypermutation suggests a second B cell diversification pathway in humans (365 citations)
  • Munc18-2 deficiency causes familial hemophagocytic lymphohistiocytosis type 5 and impairs cytotoxic granule exocytosis in patient NK cells. (271 citations)

What are the main themes of her work throughout her whole career to date?

Her scientific interests lie mostly in Immunology, Hemophagocytic lymphohistiocytosis, Perforin, Cell biology and Genetics. Her Immunology study combines topics in areas such as Mutation and Severe combined immunodeficiency. Her study in Hemophagocytic lymphohistiocytosis is interdisciplinary in nature, drawing from both Immunopathology, CD8, Pediatrics and Familial Hemophagocytic Lymphohistiocytosis.

Her study looks at the relationship between Perforin and topics such as Cell activation, which overlap with Cytokine and Lymphocyte homeostasis. Her research integrates issues of Exocytosis, Immunological synapse, Degranulation and Granule in her study of Cell biology. Her work carried out in the field of Exocytosis brings together such families of science as Endosome and Lymphocyte.

She most often published in these fields:

  • Immunology (96.69%)
  • Hemophagocytic lymphohistiocytosis (62.91%)
  • Perforin (41.72%)

What were the highlights of her more recent work (between 2014-2021)?

  • Immunology (96.69%)
  • Hemophagocytic lymphohistiocytosis (62.91%)
  • Immunopathology (23.18%)

In recent papers she was focusing on the following fields of study:

Geneviève de Saint Basile spends much of her time researching Immunology, Hemophagocytic lymphohistiocytosis, Immunopathology, T cell and Perforin. Her Immunology research is multidisciplinary, relying on both Mutation and Inflammatory bowel disease. The Hemophagocytic lymphohistiocytosis study combines topics in areas such as Cytopenia, Familial Hemophagocytic Lymphohistiocytosis and UNC13D.

Her Cytopenia study integrates concerns from other disciplines, such as Inflammation, Myeloproliferative Disorders and CD8. Geneviève de Saint Basile combines subjects such as Wolman disease, Gene mutation, Lymphocyte, Lymphoma and Genetic testing with her study of Familial Hemophagocytic Lymphohistiocytosis. Her Pathogenesis research incorporates elements of Virus, CTL*, Immune disorder and Lymphocytic choriomeningitis.

Between 2014 and 2021, her most popular works were:

  • Therapeutic effect of JAK1/2 blockade on the manifestations of hemophagocytic lymphohistiocytosis in mice (100 citations)
  • Therapeutic effect of JAK1/2 blockade on the manifestations of hemophagocytic lymphohistiocytosis in mice (100 citations)
  • Therapeutic effect of JAK1/2 blockade on the manifestations of hemophagocytic lymphohistiocytosis in mice (100 citations)

In her most recent research, the most cited papers focused on:

  • Gene
  • Mutation
  • Genetics

The scientist’s investigation covers issues in Immunology, Immunopathology, Hemophagocytic lymphohistiocytosis, Immune disorder and Pathogenesis. Her Immunology research covers fields of interest such as STAT protein, HAVCR2 and Population. Her STAT protein research includes elements of Ruxolitinib, Cytopenia, CD8, Janus kinase 1 and Myeloproliferative Disorders.

Geneviève de Saint Basile integrates several fields in her works, including HAVCR2, Immune system, T cell, T-cell lymphoma, Germline mutation and Subcutaneous Panniculitis-Like T-Cell Lymphoma. Her specific area of interest is Immune system, where she studies Innate immune system. The concepts of her Immune disorder study are interwoven with issues in Virus, CTL* and Lymphocytic choriomeningitis.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Munc13-4 Is Essential for Cytolytic Granules Fusion and Is Mutated in a Form of Familial Hemophagocytic Lymphohistiocytosis (FHL3)

Jérôme Feldmann;Isabelle Callebaut;Graça Raposo;Stéphanie Certain.
Cell (2003)

960 Citations

CD40-CD40L independent Ig gene hypermutation suggests a second B cell diversification pathway in humans

Sandra Weller;Ahmad Faili;Corinne Garcia;Moritz C. Braun.
Proceedings of the National Academy of Sciences of the United States of America (2001)

564 Citations

Molecular mechanisms of biogenesis and exocytosis of cytotoxic granules.

Geneviève de Saint Basile;Geneviève de Saint Basile;Geneviève de Saint Basile;Gaël Ménasché;Gaël Ménasché;Alain Fischer;Alain Fischer;Alain Fischer.
Nature Reviews Immunology (2010)

398 Citations

Munc18-2 deficiency causes familial hemophagocytic lymphohistiocytosis type 5 and impairs cytotoxic granule exocytosis in patient NK cells.

Marjorie Côte;Mickaël M. Ménager;Agathe Burgess;Nizar Mahlaoui.
Journal of Clinical Investigation (2009)

356 Citations

Griscelli syndrome restricted to hypopigmentation results from a melanophilin defect (GS3) or a MYO5A F-exon deletion (GS1)

Gaël Ménasché;Chen Hsuan Ho;Ozden Sanal;Jérôme Feldmann.
Journal of Clinical Investigation (2003)

352 Citations

Early and prolonged intravenous immunoglobulin replacement therapy in childhood agammaglobulinemia: a retrospective survey of 31 patients.

Pierre Quartier;Marianne Debré;Jacques De Blic;Rodolphe de Sauverzac.
The Journal of Pediatrics (1999)

348 Citations

Autoimmunity in Wiskott-Aldrich syndrome: risk factors, clinical features, and outcome in a single-center cohort of 55 patients.

Sophie Dupuis-Girod;Jacques Medioni;Elie Haddad;Pierre Quartier.
Pediatrics (2003)

342 Citations

Molecular basis of the spectral expression of CIAS1 mutations associated with phagocytic cell-mediated autoinflammatory disorders CINCA/NOMID, MWS, and FCU.

Bénédicte Neven;Isabelle Callebaut;Anne-Marie Prieur;Jérôme Feldmann.
Blood (2004)

332 Citations

Clinical similarities and differences of patients with X-linked lymphoproliferative syndrome type 1 (XLP-1/SAP-deficiency) versus type 2 (XLP-2/XIAP-deficiency)

Jana Pachlopnik Schmid;Jana Pachlopnik Schmid;Danielle Canioni;Despina Moshous;Despina Moshous;Fabien Touzot.
Blood (2011)

308 Citations

Spectrum of perforin gene mutations in familial hemophagocytic lymphohistiocytosis

Kim Göransdotter Ericson;Bengt Fadeel;Sofie Nilsson-Ardnor;Cilla Söderhäll.
American Journal of Human Genetics (2001)

306 Citations

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