World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
64
Citations
18844
World Ranking
9505
National Ranking
4197

Overview

Katerina Akassoglou is affiliated with the University of California, San Francisco in the United States. Their research spans multiple disciplines within medicine and neuroscience, with a particular focus on neuroinflammation and neurodegeneration mechanisms. Over the course of their career, they have contributed extensively to understanding immune system interactions in neurological conditions and disease processes.

The scientist's primary fields of study include:

  • Medicine
  • Neuroscience

Within these broader fields, their work further specializes in the subfields of:

  • Neurology
  • Physiology
  • Immunology
  • Cellular and Molecular Neuroscience
  • Molecular Biology

The main research topics explored by Akassoglou are:

  • Neuroinflammation and Neurodegeneration Mechanisms
  • Alzheimer's disease research and treatments
  • Immune cells in cancer
  • Neurogenesis and neuroplasticity mechanisms
  • Barrier Structure and Function Studies
  • Dementia and Cognitive Impairment Research
  • Tryptophan and brain disorders

They have published in a range of scientific venues, with notable frequency in the following journals:

  • Annals of Neurology
  • Nature Immunology
  • Alzheimer's & Dementia
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Neuroinflammation

Some of the recent research papers authored or co-authored by Katerina Akassoglou are:

  • "Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation," 2020, Nature Immunology
  • "Microglial Gi-dependent dynamics regulate brain network hyperexcitability," 2020, Nature Neuroscience
  • "Defining blood-induced microglia functions in neurodegeneration through multiomic profiling," 2023, Nature Immunology
  • "Fibrinogen induces neural stem cell differentiation into astrocytes in the subventricular zone via BMP signaling," 2020, Nature Communications
  • "Fibrin drives thromboinflammation and neuropathology in COVID-19," 2024, Nature

Frequent collaborators in their research include:

  • Jae Kyu Ryu
  • Zhaoqi Yan
  • Andrew S. Mendiola
  • Mario Merlini
  • Reshmi Tognatta

Best Publications

  • NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α

    Jordi Rius;Monica Guma;Christian Schachtrup;Katerina Akassoglou

  • Suppression of Oxidative Stress by β-Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor

    Tadahiro Shimazu;Matthew D. Hirschey;John Newman;Wenjuan He

  • Fibrinogen as a key regulator of inflammation in disease

    Dimitrios Davalos;Katerina Akassoglou

  • Resolving postoperative neuroinflammation and cognitive decline

    Niccolò Terrando;Lars I Eriksson;Lars I Eriksson;Jae Kyu Ryu;Ting Yang

  • Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation

    Dimitrios Davalos;Jae Kyu Ryu;Mario Merlini;Kim M. Baeten

  • Spontaneous inflammatory demyelinating disease in transgenic mice showing central nervous system-specific expression of tumor necrosis factor alpha

    Lesley Probert;Katerina Akassoglou;Manolis Pasparakis;George Kontogeorgos

  • Chronic optical access through a polished and reinforced thinned skull

    Patrick James Drew;Andy Y. Shih;Jonathan D. Driscoll;Per Magne Knutsen

  • Fibrinogen in neurological diseases: mechanisms, imaging and therapeutics

    Mark A. Petersen;Jae Kyu Ryu;Katerina Akassoglou;Katerina Akassoglou

  • Extracellular matrix and matrix receptors in blood-brain barrier formation and stroke.

    Kim M. Baeten;Katerina Akassoglou

  • Fibrinogen Triggers Astrocyte Scar Formation by Promoting the Availability of Active TGF-β after Vascular Damage

    Christian Schachtrup;Jae K. Ryu;Matthew J. Helmrick;Eirini Vagena

  • The fibrin-derived γ377-395 peptide inhibits microglia activation and suppresses relapsing paralysis in central nervous system autoimmune disease

    Ryan A. Adams;Jan S. Bauer;Matthew J. Flick;Shoana L. Sikorski

  • Oligodendrocyte Apoptosis and Primary Demyelination Induced by Local TNF/p55TNF Receptor Signaling in the Central Nervous System of Transgenic Mice: Models for Multiple Sclerosis with Primary Oligodendrogliopathy

    Katerina Akassoglou;Jan Bauer;George Kassiotis;Manolis Pasparakis

  • Astrocyte-specific but not neuron-specific transmembrane TNF triggers inflammation and degeneration in the central nervous system of transgenic mice.

    K Akassoglou;L Probert;G Kontogeorgos;G Kollias

  • Fibrinogen Induces Microglia-Mediated Spine Elimination and Cognitive Impairment in an Alzheimer's Disease Model.

    Mario Merlini;Victoria A. Rafalski;Pamela E. Rios Coronado;T. Michael Gill

  • Metabolic control of T H 17 and induced T reg cell balance by an epigenetic mechanism

    Tao Xu;Kelly M Stewart;Xiaohu Wang;Kai Liu

  • Blood coagulation protein fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation

    Jae Kyu Ryu;Mark A. Petersen;Sara G. Murray;Kim M. Baeten

  • Fibrin Inhibits Peripheral Nerve Remyelination by Regulating Schwann Cell Differentiation

    Katerina Akassoglou;Wei Ming Yu;Pinar Akpinar;Sidney Strickland

  • Tissue plasminogen activator-mediated fibrinolysis protects against axonal degeneration and demyelination after sciatic nerve injury.

    Katerina Akassoglou;Keith W. Kombrinck;Jay L. Degen;Sidney Strickland

  • TNFR1 signalling is critical for the development of demyelination and the limitation of T-cell responses during immune-mediated CNS disease.

    Lesley Probert;Hans-Pietro Eugster;Katerina Akassoglou;Jan Bauer

  • Regulation of Hepatic Stellate Cell Differentiation by the Neurotrophin Receptor p75NTR

    Melissa A. Passino;Ryan A. Adams;Shoana L. Sikorski;Katerina Akassoglou

Frequent Co-Authors

Jae K. Ryu
Jae K. Ryu Gladstone Institutes
Lesley Probert
Lesley Probert Institut Pasteur
George Kollias
George Kollias National and Kapodistrian University of Athens
Hans Lassmann
Hans Lassmann Medical University of Vienna
George Kassiotis
George Kassiotis The Francis Crick Institute
Jan Bauer
Jan Bauer Medical University of Vienna
Jay L. Degen
Jay L. Degen Cincinnati Children's Hospital Medical Center
Mark H. Ellisman
Mark H. Ellisman University of California, San Diego
Manolis Pasparakis
Manolis Pasparakis University of Cologne
Li Gan
Li Gan Cornell University

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