Lesley Probert

Best Publications

• Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis.

  J. Keffer;L. Probert;H. Cazlaris;S. Georgopoulos

  2001
  Citations

• Interleukin 6 is required for the development of collagen-induced arthritis.

  Tonino Alonzi;Elena Fattori;Domenico Lazzaro;Patrizia Costa

  782
  Citations

• Spontaneous inflammatory demyelinating disease in transgenic mice showing central nervous system-specific expression of tumor necrosis factor alpha

  Lesley Probert;Katerina Akassoglou;Manolis Pasparakis;George Kontogeorgos

  486
  Citations

• TNF and its receptors in the CNS: The essential, the desirable and the deleterious effects

  Unknown

  479
  Citations

• Chronic Tumor Necrosis Factor Alters T Cell Responses by Attenuating T Cell Receptor Signaling

  Andrew P. Cope;Roland S. Liblau;Xiao-Dong Yang;Mauro Congia

  351
  Citations

• Oligodendrocyte Apoptosis and Primary Demyelination Induced by Local TNF/p55TNF Receptor Signaling in the Central Nervous System of Transgenic Mice: Models for Multiple Sclerosis with Primary Oligodendrogliopathy

  Katerina Akassoglou;Jan Bauer;George Kassiotis;Manolis Pasparakis

  336
  Citations

• Astrocyte-specific but not neuron-specific transmembrane TNF triggers inflammation and degeneration in the central nervous system of transgenic mice.

  K Akassoglou;L Probert;G Kontogeorgos;G Kollias

  332
  Citations

• Increased Citrullination of Histone H3 in Multiple Sclerosis Brain and Animal Models of Demyelination: A Role for Tumor Necrosis Factor-Induced Peptidylarginine Deiminase 4 Translocation

  Fabrizio G. Mastronardi;D. Denise Wood;Jiang Mei;Reinout Raijmakers

  332
  Citations

• The mouse/human chimeric monoclonal antibody cA2 neutralizes TNF in vitro and protects transgenic mice from cachexia and TNF lethality in vivo.

  Scott A. Siegel;David J. Shealy;Marian T. Nakada;Junming Le

  323
  Citations

• TNFR1 signalling is critical for the development of demyelination and the limitation of T-cell responses during immune-mediated CNS disease.

  Lesley Probert;Hans-Pietro Eugster;Katerina Akassoglou;Jan Bauer

  219
  Citations

• The type I interleukin-1 receptor acts in series with tumor necrosis factor (TNF) to induce arthritis in TNF-transgenic mice

  Lesley Probert;David Plows;George Kontogeorgos;George Kollias

  211
  Citations

• TNF-α transgenic and knockout models of CNS inflammation and degeneration

  L Probert;K Akassoglou;G Kassiotis;M Pasparakis

  206
  Citations

• Tissue localization and relative distribution of regulatory peptides in separated layers from the human bowel

  Gian-Luca Ferri;Thomas E. Adrian;Mohammad A. Ghatei;Denis J. O'Shaughnessy

  195
  Citations

• Ischemic Neuronal Damage

  Era Taoufik;Lesley Probert

  192
  Citations

• Fibrin depletion decreases inflammation and delays the onset of demyelination in a tumor necrosis factor transgenic mouse model for multiple sclerosis

  Katerina Akassoglou;Ryan A. Adams;Jan Bauer;Peter Mercado

  185
  Citations

• TNF receptor I sensitizes neurons to erythropoietin- and VEGF-mediated neuroprotection after ischemic and excitotoxic injury.

  Era Taoufik;Edwige Petit;Didier Divoux;Vivian Tseveleki

  163
  Citations

• Double immunogold staining method for the simultaneous ultrastructural localization of regulatory peptides.

  Félix J. Tapia;I M Varndell;L Probert;J De Mey

  147
  Citations

• Inflammation and Oxidative Stress in Multiple Sclerosis: Consequences for Therapy Development.

  Valentina Pegoretti;Kathryn A Swanson;John R Bethea;Lesley Probert

  147
  Citations

• Oxidative tissue injury in multiple sclerosis is only partly reflected in experimental disease models

  Cornelia Schuh;Isabella Wimmer;Simon Hametner;Lukas Haider

  145
  Citations

• Transgenic and knockout analyses of the role of TNF in immune regulation and disease pathogenesis.

  E Douni;K Akassoglou;L Alexopoulou;S Georgopoulos

  144
  Citations