World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
52
Citations
10615
World Ranking
16620
National Ranking
6874

Overview

Jae K. Ryu is affiliated with the Gladstone Institutes in the United States and has contributed extensively to the fields of medicine and neuroscience. Their research primarily intersects neurology and immunology, with additional work spanning molecular biology, pediatrics, perinatology, and cellular and molecular neuroscience.

The scientist's recent publication record highlights a focus on neuroinflammation, neurodegeneration, and immune-related mechanisms in brain pathology. Notable papers include:

  • "Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation" (2020, Nature Immunology)
  • "Microglial Gi-dependent dynamics regulate brain network hyperexcitability" (2020, Nature Neuroscience)
  • "Defining blood-induced microglia functions in neurodegeneration through multiomic profiling" (2023, Nature Immunology)
  • "Fibrin drives thromboinflammation and neuropathology in COVID-19" (2024, Nature)
  • "Fibrin promotes oxidative stress and neuronal loss in traumatic brain injury via innate immune activation" (2024, Journal of Neuroinflammation)

Their work frequently appears in prominent journals, with multiple publications in Nature Immunology and the Journal of Neuroinflammation, as well as contributions to Nature Neuroscience and bioRxiv. The distribution of their publications among venues includes:

  • Nature Immunology
  • Journal of Neuroinflammation
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Alzheimer's & Dementia
  • Nature Neuroscience

Jae K. Ryu collaborates regularly with several co-authors, reflecting interdisciplinary research networks. Frequent collaborators include:

  • Katerina Akassoglou
  • Zhaoqi Yan
  • Andrew S. Mendiola
  • Mark A. Petersen
  • Mario Merlini

The thematic scope of their research includes topics such as neuroinflammation and neurodegeneration mechanisms, immune cells in cancer, peroxisome proliferator-activated receptors, COVID-19 clinical research studies, dermatological and COVID-19 studies, acute ischemic stroke management, and neonatal and fetal brain pathology.

Jae K. Ryu's scientific contributions span detailed molecular and cellular investigations to clinical and pathological implications of neuroinflammation and immune activation in various brain disorders and systemic conditions like COVID-19 and traumatic brain injury.

Best Publications

  • Resolving postoperative neuroinflammation and cognitive decline

    Niccolò Terrando;Lars I Eriksson;Lars I Eriksson;Jae Kyu Ryu;Ting Yang

  • Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation

    Dimitrios Davalos;Jae Kyu Ryu;Mario Merlini;Kim M. Baeten

  • A leaky blood–brain barrier, fibrinogen infiltration and microglial reactivity in inflamed Alzheimer’s disease brain

    Jae K. Ryu;James G. McLarnon

  • Fibrinogen in neurological diseases: mechanisms, imaging and therapeutics

    Mark A. Petersen;Jae Kyu Ryu;Katerina Akassoglou;Katerina Akassoglou

  • Fibrinogen Triggers Astrocyte Scar Formation by Promoting the Availability of Active TGF-β after Vascular Damage

    Christian Schachtrup;Jae K. Ryu;Matthew J. Helmrick;Eirini Vagena

  • Upregulated Expression of Purinergic P2X7 Receptor in Alzheimer Disease and Amyloid-β Peptide-Treated Microglia and in Peptide-Injected Rat Hippocampus

    James G. McLarnon;Jae K. Ryu;Douglas G. Walker;Hyun B. Choi

  • Fibrinogen Induces Microglia-Mediated Spine Elimination and Cognitive Impairment in an Alzheimer's Disease Model.

    Mario Merlini;Victoria A. Rafalski;Pamela E. Rios Coronado;T. Michael Gill

  • Fractalkine and fractalkine receptors in human neurons and glial cells

    Kozo Hatori;Atsushi Nagai;Rochelle Heisel;Jae K. Ryu

  • Metabolic control of T H 17 and induced T reg cell balance by an epigenetic mechanism

    Tao Xu;Kelly M Stewart;Xiaohu Wang;Kai Liu

  • Blood coagulation protein fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation

    Jae Kyu Ryu;Mark A. Petersen;Sara G. Murray;Kim M. Baeten

  • Metabolic communication between astrocytes and neurons via bicarbonate-responsive soluble adenylyl cyclase.

    Hyun B. Choi;Grant R.J. Gordon;Ning Zhou;Ning Zhou;Chao Tai

  • Modulation of the Purinergic P2X7 Receptor Attenuates Lipopolysaccharide-Mediated Microglial Activation and Neuronal Damage in Inflamed Brain

    Hyun B. Choi;Jae K. Ryu;Seung U. Kim;James G. McLarnon

  • Proactive transplantation of human neural stem cells prevents degeneration of striatal neurons in a rat model of Huntington disease.

    Jae K Ryu;Jean Kim;Sung J Cho;Kozo Hatori

  • Fibrinogen Activates BMP Signaling in Oligodendrocyte Progenitor Cells and Inhibits Remyelination after Vascular Damage

    Mark A. Petersen;Mark A. Petersen;Jae Kyu Ryu;Kae Jiun Chang;Ainhoa Etxeberria

  • Minocycline inhibits neuronal death and glial activation induced by beta-amyloid peptide in rat hippocampus.

    Jae K. Ryu;Sonia Franciosi;Prasongchai Sattayaprasert;Seung U. Kim;Seung U. Kim

  • Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration.

    Jae Kyu Ryu;Victoria A. Rafalski;Anke Meyer-Franke;Ryan A. Adams

  • Adenosine triphosphate induces proliferation of human neural stem cells: Role of calcium and p70 ribosomal protein S6 kinase.

    Jae K. Ryu;Hyun B. Choi;Kozo Hatori;Rochelle L. Heisel

  • Block of purinergic P2X7 receptor is neuroprotective in an animal model of Alzheimer's disease

    Jae K. Ryu;James G. McLarnon

  • Microglial VEGF Receptor Response Is an Integral Chemotactic Component in Alzheimer's Disease Pathology

    Jae K. Ryu;Taesup Cho;Hyun B. Choi;Yu Tian Wang

  • SIRT1 deacetylates RORγt and enhances Th17 cell generationSIRT1 regulates Th17 cell function

    Hyung W. Lim;Seung Goo Kang;Jae Kyu Ryu;Birgit Schilling

Frequent Co-Authors

Katerina Akassoglou
Katerina Akassoglou University of California, San Francisco
James G. McLarnon
James G. McLarnon University of British Columbia
Seung U. Kim
Seung U. Kim University of British Columbia
Mark H. Ellisman
Mark H. Ellisman University of California, San Diego
Scott S. Zamvil
Scott S. Zamvil University of California, San Francisco
Jay L. Degen
Jay L. Degen Cincinnati Children's Hospital Medical Center
Lennart Mucke
Lennart Mucke University of California, San Francisco
Miles D. Houslay
Miles D. Houslay King's College London
Hans Lassmann
Hans Lassmann Medical University of Vienna
Yu Tian Wang
Yu Tian Wang University of British Columbia

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