D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 64 Citations 15,688 140 World Ranking 6215 National Ranking 58

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Enzyme
  • Cancer

Leif R. Lund mostly deals with Molecular biology, Plasminogen activator, Matrix metalloproteinase, Stromal cell and Cell biology. The various areas that Leif R. Lund examines in his Molecular biology study include Urokinase receptor, Receptor, Integrin and Transforming growth factor. His biological study spans a wide range of topics, including Cell culture, Cycloheximide, Plasmin and Urokinase.

His work investigates the relationship between Urokinase and topics such as Diisopropyl fluorophosphate that intersect with problems in Proteases. In his study, Mammary gland, Cathepsin K, Osteoclast and Interstitial collagenase is inextricably linked to Endocrinology, which falls within the broad field of Matrix metalloproteinase. His study in Stromal cell is interdisciplinary in nature, drawing from both Cancer cell, Extracellular matrix, Cell type and Gelatinase.

His most cited work include:

  • Impaired wound healing in mice with a disrupted plasminogen gene. (507 citations)
  • Two distinct phases of apoptosis in mammary gland involution: proteinase-independent and -dependent pathways. (457 citations)
  • Plasminogen activator inhibitors: hormonally regulated serpins (363 citations)

What are the main themes of his work throughout his whole career to date?

The scientist’s investigation covers issues in Plasminogen activator, Molecular biology, Urokinase, Cell biology and Urokinase receptor. The Plasminogen activator study combines topics in areas such as Kallikrein, Cancer research, Angiogenesis and Plasmin. His studies in Molecular biology integrate themes in fields like Cell culture, Messenger RNA, In situ hybridization and Monoclonal antibody.

While the research belongs to areas of Urokinase, Leif R. Lund spends his time largely on the problem of Pathology, intersecting his research to questions surrounding Cancer and Adenocarcinoma. His work deals with themes such as Proteases, Epithelium, Stromal cell and Matrix metalloproteinase, which intersect with Cell biology. His Matrix metalloproteinase research is multidisciplinary, incorporating elements of Extracellular matrix, Endocrinology and Immunology.

He most often published in these fields:

  • Plasminogen activator (43.43%)
  • Molecular biology (42.42%)
  • Urokinase (27.27%)

What were the highlights of his more recent work (between 2008-2015)?

  • Metastasis (9.09%)
  • Immunology (12.12%)
  • Cancer research (18.18%)

In recent papers he was focusing on the following fields of study:

Metastasis, Immunology, Cancer research, Plasminogen activator inhibitor-1 and Stromal cell are his primary areas of study. His Metastasis research includes themes of Urokinase receptor, Colorectal cancer, Breast cancer and Carcinogenesis. His research integrates issues of Gelatinase A and Gelatinase in his study of Immunology.

As part of his studies on Cancer research, Leif R. Lund frequently links adjacent subjects like Plasminogen activator. His Plasminogen activator inhibitor-1 research integrates issues from Urokinase, Vascular remodelling in the embryo, Pathology, Liver cancer and Mouse mammary tumor virus. The study incorporates disciplines such as Extracellular matrix, Genetically modified mouse, Primary tumor and Matrix metalloproteinase in addition to Stromal cell.

Between 2008 and 2015, his most popular works were:

  • Interleukin (IL)-23 mediates Toxoplasma gondii-induced immunopathology in the gut via matrixmetalloproteinase-2 and IL-22 but independent of IL-17. (221 citations)
  • RSK is a principal effector of the RAS-ERK pathway for eliciting a coordinate promotile/invasive gene program and phenotype in epithelial cells. (165 citations)
  • Two distinct expression patterns of urokinase, urokinase receptor and plasminogen activator inhibitor‐1 in colon cancer liver metastases (68 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Enzyme
  • Cancer

His primary areas of study are Ileitis, Metastasis, Urokinase receptor, Liver cancer and Pathology. Other disciplines of study, such as Gelatinase A, Interleukin, Gelatinase, Interleukin 22 and Immunology, are mixed together with his Ileitis studies. His Gelatinase A research incorporates themes from Interleukin 23, Interleukin 17 and Lamina propria.

His Metastasis study combines topics from a wide range of disciplines, such as Plasminogen activator inhibitor-1, Stromal cell, Colorectal cancer and Urokinase.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Impaired wound healing in mice with a disrupted plasminogen gene.

J Romer;T H Bugge;T H Bugge;C Pyke;L R Lund.
Nature Medicine (1996)

802 Citations

Two distinct phases of apoptosis in mammary gland involution: proteinase-independent and -dependent pathways.

Leif R. Lund;John Rømer;Nicole Thomasset;Helene Solberg.
Development (1996)

705 Citations

Plasminogen activator inhibitors: hormonally regulated serpins

Peter A. Andreasen;Birgitte Georg;Leif R. Lund;Andrea Riccio.
Molecular and Cellular Endocrinology (1990)

579 Citations

Cancer invasion and tissue remodeling: common themes in proteolytic matrix degradation

Morten Johnsen;Leif R Lund;John Rømer;Kasper Almholt.
Current Opinion in Cell Biology (1998)

498 Citations

The Plasminogen Activator Inhibitor PAI-1 Controls In Vivo Tumor Vascularization by Interaction with Proteases, Not Vitronectin: Implications for Antiangiogenic Strategies

Khalid Bajou;Véronique Masson;Robert D. Gerard;Petra M. Schmitt.
Journal of Cell Biology (2001)

406 Citations

The gamma 2 chain of kalinin/laminin 5 is preferentially expressed in invading malignant cells in human cancers.

C. Pyke;J. Rømer;P. Kallunki;L. R. Lund.
American Journal of Pathology (1994)

397 Citations

Cancer invasion and tissue remodeling--cooperation of protease systems and cell types.

Keld Danø;John Rømer;Boye S. Nielsen;Signe Bjørn.
Apmis (1999)

373 Citations

Urokinase receptor (CD87) regulates leukocyte recruitment via beta 2 integrins in vivo.

Andreas E. May;Sandip M. Kanse;Leif R. Lund;Roland H. Gisler.
Journal of Experimental Medicine (1998)

339 Citations

Functional overlap between two classes of matrix‐degrading proteases in wound healing

Leif R. Lund;John Rømer;Thomas H. Bugge;Boye S. Nielsen.
The EMBO Journal (1999)

338 Citations

Site-specific inductive and inhibitory activities of MMP-2 and MMP-3 orchestrate mammary gland branching morphogenesis

Bryony S. Wiseman;Mark D. Sternlicht;Leif R. Lund;Caroline M. Alexander.
Journal of Cell Biology (2003)

337 Citations

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