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Biology and Biochemistry

D-Index
69
Citations
13662
World Ranking
7556
National Ranking
70

Overview

Michael Ploug is affiliated with the University of Copenhagen in Denmark, focusing primarily on the fields of medicine and biochemistry, genetics, and molecular biology. Their research spans various subfields, including cardiology and cardiovascular medicine, endocrinology, diabetes and metabolism, molecular biology, cancer research, and genetics.

The scientist's main research topics cover lipid metabolism and disorders, diabetes, cardiovascular risks and lipoproteins, caveolin-1 and cellular processes, diabetes and associated disorders, protease and inhibitor mechanisms, peptidase inhibition and analysis, and cell adhesion molecules research.

Michael Ploug has published extensively in high-profile scientific venues. Frequent publication venues include:

  • Proceedings of the National Academy of Sciences
  • Journal of Lipid Research
  • Frontiers in Cell and Developmental Biology
  • Journal of Clinical Investigation
  • JCI Insight

Recent publications reflecting their research interests include:

  • The Importance of Lipoprotein Lipase Regulation in Atherosclerosis, 2021, Biomedicines
  • Unfolding of monomeric lipoprotein lipase by ANGPTL4: Insight into the regulation of plasma triglyceride metabolism, 2020, Proceedings of the National Academy of Sciences
  • The intrinsic instability of the hydrolase domain of lipoprotein lipase facilitates its inactivation by ANGPTL4-catalyzed unfolding, 2021, Proceedings of the National Academy of Sciences
  • Chylomicronemia from GPIHBP1 autoantibodies, 2020, Journal of Lipid Research
  • The Urokinase Receptor (uPAR) as a "Trojan Horse" in Targeted Cancer Therapy: Challenges and Opportunities, 2021, Cancers

Collaboration is a marked aspect of Ploug's work, with frequent co-authors including Stephen G. Young, Anne P. Beigneux, Loren G. Fong, Anni Kumari, and Kristian Kølby Kristensen. This network indicative of active research in lipid metabolism and related molecular pathways.

Best Publications

  • Cellular receptor for urokinase plasminogen activator. Carboxyl-terminal processing and membrane anchoring by glycosyl-phosphatidylinositol.

    M Ploug;E Rønne;N Behrendt;A L Jensen

  • Plasminogen activation and cancer

    Keld Danø;Niels Behrendt;Gunilla Høyer-Hansen;Morten Johnsen

  • The human receptor for urokinase plasminogen activator. NH2-terminal amino acid sequence and glycosylation variants.

    N Behrendt;E Rønne;M Ploug;T Petri

  • Structure—function relationships in the receptor for urokinase-type plasminogen activator Comparison to other members of the Ly-6 family and snake venom α-neurotoxins

    Michael Ploug;Vincent Ellis

  • The urokinase receptor. Protein structure and role in plasminogen activation and cancer invasion

    K. Danø;N. Behrendt;N. Brunner;V. Ellis

  • The ligand-binding domain of the cell surface receptor for urokinase-type plasminogen activator.

    N Behrendt;M Ploug;L Patthy;G Houen

  • Urokinase plasminogen activator cleaves its cell surface receptor releasing the ligand-binding domain.

    G Høyer-Hansen;E Rønne;H Solberg;N Behrendt

  • Crystal structure of the human urokinase plasminogen activator receptor bound to an antagonist peptide

    Paola Llinas;Marie Hélène Le Du;Henrik Gårdsvoll;Keld Danø

  • Peptide-Derived Antagonists of the Urokinase Receptor. Affinity Maturation by Combinatorial Chemistry, Identification of Functional Epitopes, and Inhibitory Effect on Cancer Cell Intravasation†

    Michael Ploug;Søren Østergaard;Henrik Gårdsvoll;Katherine Kovalski

  • Structure, Function and Expression on Blood and Bone Marrow Cells of the Urokinase‐Type Plasminogen Activator Receptor, uPAR

    T. Plesner;N. Behrendt;M. Ploug

  • Intramolecular migration of amide hydrogens in protonated peptides upon collisional activation.

    Thomas J. D. Jørgensen;Henrik Gårdsvoll;Michael Ploug;Peter Roepstorff

  • Structure-Function Relationships in the Interaction Between the Urokinase- Type Plasminogen Activator and Its Receptor

    Michael Ploug

  • Cell-induced potentiation of the plasminogen activation system is abolished by a monoclonal antibody that recognizes the NH2-terminal domain of the urokinase receptor.

    Ebbe Rønne;Niels Behrendt;Vincent Ellis;Michael Ploug

  • Determination of amino acid compositions and NH2-terminal sequences of peptides electroblotted onto PVDF membranes from tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis: application to peptide mapping of human complement component C3.

    Michael Ploug;Arne L. Jensen;Vibeke Barkholt

  • The receptor for urokinase-type plasminogen activator and urokinase is translocated from two distinct intracellular compartments to the plasma membrane on stimulation of human neutrophils

    T Plesner;M Ploug;V Ellis;E Ronne

  • The intact urokinase receptor is required for efficient vitronectin binding: receptor cleavage prevents ligand interaction

    Gunilla Høyer-Hansen;Niels Behrendt;Michael Ploug;Keld Danø

  • Localization of the disulfide bonds in the NH2-terminal domain of the cellular receptor for human urokinase-type plasminogen activator. A domain structure belonging to a novel superfamily of glycolipid-anchored membrane proteins.

    M Ploug;M Kjalke;E Rønne;U Weidle

  • The receptor for urokinase-type plasminogen activator is deficient on peripheral blood leukocytes in patients with paroxysmal nocturnal hemoglobinuria.

    Michael Ploug;Torben Plesner;Ebbe RØnne;Vincent Ellis

  • Protein structure and membrane anchorage of the cellular receptor for urokinase-type plasminogen activator.

    Michael Ploug;Niels Behrendt;Dorte Løber;Keld Danø

  • The Urokinase Receptor. Protein Structure and Role in Plasminogen Activation and Cancer Invasion

    K. Danø;N. Behrendt;B. Brunner;V. Ellis

Frequent Co-Authors

Keld Danø
Keld Danø Copenhagen University Hospital
Niels Behrendt
Niels Behrendt Technical University of Denmark
Stephen G. Young
Stephen G. Young University of California, Los Angeles
Gunilla Høyer-Hansen
Gunilla Høyer-Hansen University of Copenhagen
Anne P. Beigneux
Anne P. Beigneux University of California, Los Angeles
Thomas J. D. Jørgensen
Thomas J. D. Jørgensen University of Southern Denmark
Loren G. Fong
Loren G. Fong University of California, Los Angeles
Mingdong Huang
Mingdong Huang Fuzhou University
Andreas Kjaer
Andreas Kjaer University of Copenhagen
Leif R. Lund
Leif R. Lund University of Copenhagen

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