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Biology and Biochemistry

D-Index
51
Citations
8782
World Ranking
17227
National Ranking
7089

Overview

Anne P. Beigneux is affiliated with the University of California, Los Angeles in the United States. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a focus on several subfields including Cardiology and Cardiovascular Medicine, Endocrinology, Diabetes and Metabolism, Cell Biology, Genetics, and Biochemistry.

The main topics of their research include:

  • Lipid metabolism and disorders
  • Diabetes, Cardiovascular Risks, and Lipoproteins
  • Caveolin-1 and cellular processes
  • Diabetes and associated disorders
  • Lipid metabolism and biosynthesis
  • Metabolism, Diabetes, and Cancer
  • Adipose Tissue and Metabolism

Anne P. Beigneux has published research in several journals, notably:

  • Journal of Lipid Research (3 publications)
  • Proceedings of the National Academy of Sciences (3 publications)
  • Journal of Clinical Investigation (2 publications)
  • Journal of Clinical Lipidology (1 publication)
  • Annals of Internal Medicine (1 publication)

Among their recent papers are:

  • "Chylomicronemia from GPIHBP1 autoantibodies" published in 2020 in the Journal of Lipid Research
  • "A protein of capillary endothelial cells, GPIHBP1, is crucial for plasma triglyceride metabolism" published in 2022 in Proceedings of the National Academy of Sciences
  • "The lipoprotein lipase that is shuttled into capillaries by GPIHBP1 enters the glycocalyx where it mediates lipoprotein processing" published in 2023 in Proceedings of the National Academy of Sciences
  • "The structural basis for monoclonal antibody 5D2 binding to the tryptophan-rich loop of lipoprotein lipase" published in 2020 in Journal of Lipid Research
  • "Hypertriglyceridemia in Apoa5-/- mice results from reduced amounts of lipoprotein lipase in the capillary lumen" published in 2023 in Journal of Clinical Investigation

Their collaborations include frequent coauthors such as Stephen G. Young, Michael Ploug, Loren G. Fong, Wenxin Song, and Ye Yang, with collaboration counts ranging from seven to twelve publications with each.

Best Publications

  • ESCRT-III dysfunction causes autophagosome accumulation and neurodegeneration.

    Jin-A Lee;Anne Beigneux;S. Tariq Ahmad;Stephen G. Young

  • Glycosylphosphatidylinositol-Anchored High-Density Lipoprotein-Binding Protein 1 Plays a Critical Role in the Lipolytic Processing of Chylomicrons

    Anne P. Beigneux;Brandon S.J. Davies;Peter Gin;Michael M. Weinstein

  • Up-regulation of peroxisome proliferator-activated receptors (PPAR-alpha) and PPAR-gamma messenger ribonucleic acid expression in the liver in murine obesity: troglitazone induces expression of PPAR-gamma-responsive adipose tissue-specific genes in the liver of obese diabetic mice.

    Riaz A. Memon;Laurence H. Tecott;Katsunori Nonogaki;Anne Beigneux

  • GPIHBP1 Is Responsible for the Entry of Lipoprotein Lipase into Capillaries

    Brandon S.J. Davies;Anne P. Beigneux;Richard H. Barnes;Yiping Tu

  • Blocking protein farnesyltransferase improves nuclear shape in fibroblasts from humans with progeroid syndromes

    Julia I. Toth;Shao H. Yang;Xin Qiao;Anne P. Beigneux

  • Disruption of the Phosphatidylserine Decarboxylase Gene in Mice Causes Embryonic Lethality and Mitochondrial Defects

    Rineke Steenbergen;Terry S. Nanowski;Anne Beigneux;Agnes Kulinski

  • The acute phase response is associated with retinoid X receptor repression in rodent liver.

    Anne P. Beigneux;Arthur H. Moser;Judy K. Shigenaga;Carl Grunfeld

  • Reduction in cytochrome P-450 enzyme expression is associated with repression of CAR (constitutive androstane receptor) and PXR (pregnane X receptor) in mouse liver during the acute phase response.

    Anne P Beigneux;Arthur H Moser;Judy K Shigenaga;Carl Grunfeld

  • Regulation of prelamin A but not lamin C by miR-9, a brain-specific microRNA

    Hea-Jin Jung;Catherine Coffinier;Youngshik Choe;Anne P. Beigneux

  • Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf

    Martin O. Bergo;Bryant J. Gavino;Christine Hong;Anne P. Beigneux

  • AGPAT6 Is a Novel Microsomal Glycerol-3-phosphate Acyltransferase

    Yan Qun Chen;Ming-Shang Kuo;Shuyu Li;Hai H. Bui

  • ATP-Citrate Lyase Deficiency in the Mouse

    Anne P. Beigneux;Cynthia Kosinski;Bryant Gavino;Jay D. Horton

  • Chylomicronemia With a Mutant GPIHBP1 (Q115P) That Cannot Bind Lipoprotein Lipase

    Anne P Beigneux;Remco Franssen;André Bensadoun;Peter Gin

  • Agpat6 deficiency causes subdermal lipodystrophy and resistance to obesity.

    Laurent Vergnes;Anne P. Beigneux;Ryan Davis;Steven M. Watkins

  • The GPIHBP1–LPL Complex Is Responsible for the Margination of Triglyceride-Rich Lipoproteins in Capillaries

    Chris N. Goulbourne;Peter Gin;Angelica Tatar;Chika Nobumori

  • Agpat6--a novel lipid biosynthetic gene required for triacylglycerol production in mammary epithelium.

    Anne P. Beigneux;Laurent Vergnes;Xin Qiao;Steven Quatela

  • Chylomicronemia with low postheparin lipoprotein lipase levels in the setting of GPIHBP1 defects.

    Remco Franssen;Stephen G. Young;Frank Peelman;Jozef Hertecant

  • Autoantibodies against GPIHBP1 as a Cause of Hypertriglyceridemia.

    Anne P. Beigneux;Kazuya Miyashita;Michael Ploug;Dirk J. Blom

  • Mutation of conserved cysteines in the Ly6 domain of GPIHBP1 in familial chylomicronemia.

    Gunilla Olivecrona;Ewa Ehrenborg;Ewa Ehrenborg;Henrik Semb;Elena Makoveichuk

  • The acidic domain of the endothelial membrane protein GPIHBP1 stabilizes lipoprotein lipase activity by preventing unfolding of its catalytic domain

    Simon Mysling;Simon Mysling;Simon Mysling;Kristian Kølby Kristensen;Kristian Kølby Kristensen;Mikael Larsson;Anne P Beigneux

Frequent Co-Authors

Stephen G. Young
Stephen G. Young University of California, Los Angeles
Loren G. Fong
Loren G. Fong University of California, Los Angeles
André Bensadoun
André Bensadoun Cornell University
Michael Ploug
Michael Ploug University of Copenhagen
Peter Tontonoz
Peter Tontonoz University of California, Los Angeles
Karen Reue
Karen Reue University of California, Los Angeles
Robert O. Ryan
Robert O. Ryan University of Nevada Reno
Jeffrey D. Esko
Jeffrey D. Esko University of California, San Diego
Christer Betsholtz
Christer Betsholtz Uppsala University
Holger Gerhardt
Holger Gerhardt Max Delbrück Center for Molecular Medicine

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