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Robert C. Liddington

Robert C. Liddington

D-Index & Metrics

Biology and Biochemistry

D-Index
78
Citations
30000
World Ranking
4462
National Ranking
2168

Overview

Robert C. Liddington is affiliated with the Discovery Institute in the United States. Their research spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a particular focus on Molecular Biology, Cell Biology, Epidemiology, Infectious Diseases, and Physiology.

Their main topics of study encompass cellular transport and secretion, erythrocyte function and pathophysiology, protein kinase regulation and GTPase signaling, autophagy in disease and therapy, metabolism, diabetes, and cancer, pancreatic function and diabetes, and mosquito-borne diseases and control.

Frequently collaborating with other researchers, Robert C. Liddington has worked alongside Alexander E. Aleshin, Yong Yao, Laurie A. Bankston, Garth Powis, and Francesca M. Marassi, each contributing to multiple publications.

Their published works appear in several scientific journals and venues including bioRxiv (Cold Spring Harbor Laboratory), Structure, Cellular Signalling, PLoS Pathogens, and Experimental Cell Research.

Significant recent papers include:

  • Structural basis for the association of PLEKHA7 with membrane-embedded phosphatidylinositol lipids, 2021, Structure
  • Cell adhesion suppresses autophagy via Src/FAK-mediated phosphorylation and inhibition of AMPK, 2021, Cellular Signalling
  • Dual function of Zika virus NS2B-NS3 protease, 2023, PLoS Pathogens
  • PLEKHA7 signaling is necessary for the growth of mutant KRAS driven colorectal cancer, 2021, Experimental Cell Research
  • Assembly and Function of the Anthrax Toxin Protein Translocation Complex, 2020, Sub-cellular biochemistry/Subcellular biochemistry

Best Publications

  • Talin Binding to Integrin ß Tails: A Final Common Step in Integrin Activation

    Seiji Tadokoro;Sanford J. Shattil;Koji Eto;Vera Tai

  • Structural and Functional Bases for Broad-Spectrum Neutralization of Avian and Human Influenza A Viruses

    Jianhua Sui;William C Hwang;Sandra Elizabeth Pérez;Ge Wei

  • Structural Basis of Collagen Recognition by Integrin α2β1

    Jonas Emsley;C.Graham Knight;Richard W. Farndale;Michael J. Barnes

  • S-nitrosylation of matrix metalloproteinases: signaling pathway to neuronal cell death.

    Zezong Gu;Marcus Kaul;Boxu Yan;Steven J. Kridel

  • Crystal structure of the anthrax toxin protective antigen.

    C Petosa;R.J Collier;K.R Klimpel;S.H Leppla

  • Structural Basis for the Inhibition of Caspase-3 by XIAP

    Stefan J. Riedl;Martin Renatus;Robert Schwarzenbacher;Qiao Zhou

  • Structure of simian virus 40 at 3.8-Å resolution

    R. C. Liddington;R. C. Liddington;Y. Yan;Y. Yan;J. Moulai;J. Moulai;R. Sahli;R. Sahli

  • Structural Basis of Integrin Activation by Talin

    Kate L. Wegener;Anthony W. Partridge;Jaewon Han;Andrew R. Pickford

  • Crystal structure of the zeta isoform of the 14-3-3 protein.

    Dong Liu;J. Bienkowska;C. Petosa;R. J. Collier

  • Stereochemistry of cooperative mechanisms in hemoglobin

    M.F. Perutz;G. Fermi;B. Luisi;B. Shaanan

  • The structure and regulation of vinculin.

    Wolfgang H. Ziegler;Robert C. Liddington;David R. Critchley

  • Dimer formation drives the activation of the cell death protease caspase 9.

    Martin Renatus;Henning R. Stennicke;Fiona L. Scott;Robert C. Liddington

  • Structural determinants of integrin recognition by talin

    Begoña Garcı́a-Alvarez;José M de Pereda;David A Calderwood;Tobias S Ulmer

  • Crystal structure of the breakage-reunion domain of DNA gyrase

    Joo H. Morais Cabral;Andrew P. Jackson;Clare V. Smith;Nita Shikotra

  • Crystal structure of the anthrax lethal factor

    AD Pannifer;TY Wong;Robert Schwarzenbacher;M Renatus

  • Two conformations of the integrin A-domain (I-domain): a pathway for activation?

    Jie-Oh Lee;Laurie Anne Bankston;M.Amin Arnaout;Robert C Liddington

  • The phosphotyrosine binding-like domain of talin activates integrins.

    David A. Calderwood;Boxu Yan;Jose M. de Pereda;Begoña Garcı́a Alvarez

  • Integrin β cytoplasmic domain interactions with phosphotyrosine-binding domains: A structural prototype for diversity in integrin signaling

    David A. Calderwood;Yosuke Fujioka;Jose M. de Pereda;Begoña García-Alvarez

  • Structural basis for vinculin activation at sites of cell adhesion

    Constantina Bakolitsa;Daniel M. Cohen;Laurie A. Bankston;Andrey A. Bobkov

  • 14-3-3zeta binds a phosphorylated Raf peptide and an unphosphorylated peptide via its conserved amphipathic groove

    Carlo Petosa;Shane C. Masters;Laurie A. Bankston;Jan Pohl

Frequent Co-Authors

Alex Y. Strongin
Alex Y. Strongin Sanford Burnham Prebys Medical Discovery Institute
John C. Reed
John C. Reed Johnson & Johnson (United States)
Wayne A. Marasco
Wayne A. Marasco Harvard University
David R. Critchley
David R. Critchley University of Leicester
Jeffrey W. Smith
Jeffrey W. Smith Sanford Burnham Prebys Medical Discovery Institute
Mark H. Ginsberg
Mark H. Ginsberg University of California, San Diego
Maurizio Pellecchia
Maurizio Pellecchia University of California, Riverside
Stephen H. Leppla
Stephen H. Leppla National Institutes of Health
Guy S. Salvesen
Guy S. Salvesen Sanford Burnham Prebys Medical Discovery Institute
Stuart A. Lipton
Stuart A. Lipton Scripps Research Institute

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