Alex Y. Strongin

Overview

Best Publications

• Mechanism Of Cell Surface Activation Of 72-kDa Type IV Collagenase ISOLATION OF THE ACTIVATED FORM OF THE MEMBRANE METALLOPROTEASE

  Alex Y. Strongin;Ivan Collier;Gregory Bannikov;Barry L. Marmer

  1998
  Citations

• Compensation mechanism in tumor cell migration: mesenchymal–amoeboid transition after blocking of pericellular proteolysis

  Katarina Wolf;Irina Mazo;Harry Leung;Katharina Engelke

  1809
  Citations

• S-nitrosylation of matrix metalloproteinases: signaling pathway to neuronal cell death.

  Zezong Gu;Marcus Kaul;Boxu Yan;Steven J. Kridel

  1200
  Citations

• Interaction of 92-kDa type IV collagenase with the tissue inhibitor of metalloproteinases prevents dimerization, complex formation with interstitial collagenase, and activation of the proenzyme with stromelysin.

  Gregory Goldberg;A. Strongin;I. E. Collier;L. T. Genrich

  730
  Citations

• A Highly Specific Inhibitor of Matrix Metalloproteinase-9 Rescues Laminin from Proteolysis and Neurons from Apoptosis in Transient Focal Cerebral Ischemia

  Zezong Gu;Jiankun Cui;Stephen Brown;Rafael Fridman

  565
  Citations

• MT1-MMP initiates activation of pro-MMP-2 and integrin alphavbeta3 promotes maturation of MMP-2 in breast carcinoma cells.

  Elena I. Deryugina;Boris Ratnikov;Edward Monosov;Tanya I. Postnova

  517
  Citations

• Plasma membrane-dependent activation of the 72-kDa type IV collagenase is prevented by complex formation with TIMP-2.

  A Y Strongin;B L Marmer;G A Grant;G I Goldberg

  451
  Citations

• Matrix-dependent Proteolysis of Surface Transglutaminase by Membrane-type Metalloproteinase Regulates Cancer Cell Adhesion and Locomotion

  Alexey M. Belkin;Sergey S. Akimov;Liubov S. Zaritskaya;Boris I. Ratnikov

  310
  Citations

• Processing of Integrin αv Subunit by Membrane Type 1 Matrix Metalloproteinase Stimulates Migration of Breast Carcinoma Cells on Vitronectin and Enhances Tyrosine Phosphorylation of Focal Adhesion Kinase

  Elena I. Deryugina;Boris I. Ratnikov;Tanya I. Postnova;Dmitri V. Rozanov

  305
  Citations

• Insights Into RNA Unwinding and ATP Hydrolysis by the Flavivirus Ns3 Protein

  Dahai Luo;Ting Xu;Randall P Watson;Daniella Scherer-Becker

  301
  Citations

• Structural evidence for regulation and specificity of flaviviral proteases and evolution of the Flaviviridae fold

  Alexander E. Aleshin;Sergey A. Shiryaev;Alex Y. Strongin;Robert C. Liddington

  254
  Citations

• Remodeling of Collagen Matrix by Human Tumor Cells Requires Activation and Cell Surface Association of Matrix Metalloproteinase-2

  Elena I. Deryugina;Mario A. Bourdon;Ralph A. Reisfeld;Alex Strongin

  242
  Citations

• Mutation Analysis of Membrane Type-1 Matrix Metalloproteinase (MT1-MMP) THE ROLE OF THE CYTOPLASMIC TAIL CYS574, THE ACTIVE SITE GLU240, AND FURIN CLEAVAGE MOTIFS IN OLIGOMERIZATION, PROCESSING, AND SELF-PROTEOLYSIS OF MT1-MMP EXPRESSED IN BREAST CARCINOMA CELLS

  Dmitry V. Rozanov;Elena I. Deryugina;Boris I. Ratnikov;Edward Z. Monosov

  230
  Citations

• Functional activation of integrin alpha V beta 3 in tumor cells expressing membrane-type 1 matrix metalloproteinase.

  Elena I. Deryugina;Mario A. Bourdon;Karli Jungwirth;Jeffrey W. Smith

  228
  Citations

• Up-Regulation of Vascular Endothelial Growth Factor by Membrane-type 1 Matrix Metalloproteinase Stimulates Human Glioma Xenograft Growth and Angiogenesis

  Elena I. Deryugina;Liliana Soroceanu;Alex Y. Strongin

  225
  Citations

• Matrix metalloproteinase-2 activation modulates glioma cell migration

  Elena I. Deryugina;Mario A. Bourdon;Guang-Xiang Luo;Ralph A. Reisfeld

  219
  Citations

• Characterization of matrix metalloproteinase-26, a novel metalloproteinase widely expressed in cancer cells of epithelial origin.

  George N. Marchenko;Boris I. Ratnikov;Dmitry V. Rozanov;Adam Godzik

  218
  Citations

• MMP-28, a new human matrix metalloproteinase with an unusual cysteine-switch sequence is widely expressed in tumors.

  George N Marchenko;Alex Y Strongin

  205
  Citations

• The Low Density Lipoprotein Receptor-related Protein LRP Is Regulated by Membrane Type-1 Matrix Metalloproteinase (MT1-MMP) Proteolysis in Malignant Cells

  Dmitri V. Rozanov;Elizabeth Hahn-Dantona;Dudley K. Strickland;Alex Y. Strongin

  194
  Citations

• Alanine scanning mutagenesis and functional analysis of the fibronectin-like collagen-binding domain from human 92-kDa type IV collagenase.

  I. E. Collier;P. A. Krasnov;A. Y. Strongin;H. Birkedal-Hansen

  194
  Citations