Motoharu Seiki

Research.com Recognitions

• 2026 - Research.com Biology and Biochemistry in Japan Leader Award
• 2025 - Research.com Biology and Biochemistry in Japan Leader Award
• 2023 - Research.com Biology and Biochemistry in Japan Leader Award

Overview

Best Publications

• A matrix metalloproteinase expressed on the surface of invasive tumour cells

  Hiroshi Sato;Takahisa Takino;Yasunori Okada;Jian Cao

  3256
  Citations

• SR alpha promoter: an efficient and versatile mammalian cDNA expression system composed of the simian virus 40 early promoter and the R-U5 segment of human T-cell leukemia virus type 1 long terminal repeat.

  Y. Takebe;M. Seiki;J.-I. Fujisawa;P. Hoy

  2172
  Citations

• Human adult T-cell leukemia virus: complete nucleotide sequence of the provirus genome integrated in leukemia cell DNA.

  Motoharu Seiki;Seisuke Hattori;Yoko Hirayama;Mitsuaki Yoshida

  1969
  Citations

• Membrane Type 1 Matrix Metalloproteinase Digests Interstitial Collagens and Other Extracellular Matrix Macromolecules

  Eiko Ohuchi;Kazushi Imai;Yutaka Fujii;Hiroshi Sato

  1173
  Citations

• Monoclonal integration of human T-cell leukemia provirus in all primary tumors of adult T-cell leukemia suggests causative role of human T-cell leukemia virus in the disease.

  M Yoshida;M Seiki;K Yamaguchi;K Takatsuki

  1090
  Citations

• Membrane-Type 1 Matrix Metalloproteinase Cleaves Cd44 and Promotes Cell Migration

  Masahiro Kajita;Yoshifumi Itoh;Tadashige Chiba;Hidetoshi Mori

  921
  Citations

• The membrane-anchored MMP inhibitor RECK is a key regulator of extracellular matrix integrity and angiogenesis.

  Junseo Oh;Rei Takahashi;Shunya Kondo;Akira Mizoguchi

  917
  Citations

• Regulatory mechanism of 92 kDa type IV collagenase gene expression which is associated with invasiveness of tumor cells

  H Sato;M Seiki

  887
  Citations

• Identification of the second membrane-type matrix metalloproteinase (MT-MMP-2) gene from a human placenta cDNA library. MT-MMPs form a unique membrane-type subclass in the MMP family.

  Takahisa Takino;Hiroshi Sato;Akira Shinagawa;Motoharu Seiki

  712
  Citations

• Induction of interleukin 2 receptor gene expression by p40x encoded by human T-cell leukemia virus type 1.

  J Inoue;M Seiki;T Taniguchi;S Tsuru

  605
  Citations

• MT1-MMP: a potent modifier of pericellular microenvironment.

  Yoshifumi Itoh;Motoharu Seiki

  573
  Citations

• Transmembrane/cytoplasmic domain-mediated membrane type 1-matrix metalloprotease docking to invadopodia is required for cell invasion

  Hirokazu Nakahara;Linda Howard;Erik W. Thompson;Hiroshi Sato

  546
  Citations

• Stimulation of 92-kDa gelatinase B promoter activity by ras is mitogen-activated protein kinase kinase 1-independent and requires multiple transcription factor binding sites including closely spaced PEA3/ets and AP-1 sequences.

  Rebecca Gum;Ernst Lengyel;Jose Juarez;Ji Hshiung Chen

  531
  Citations

• Membrane-type 1 matrix metalloproteinase: a key enzyme for tumor invasion

  Motoharu Seiki

  519
  Citations

• Homophilic complex formation of MT1-MMP facilitates proMMP-2 activation on the cell surface and promotes tumor cell invasion.

  Yoshifumi Itoh;Akiko Takamura;Noriko Ito;Yoshiro Maru

  503
  Citations

• Evidence for aberrant activation of the interleukin-2 autocrine loop by HTLV-1-encoded p40x and T3/Ti complex triggering.

  Mitsuo Maruyama;Hiroshi Shibuya;Hisashi Harada;Masanori Hatakeyama

  496
  Citations

• Involvement of Flt-1 Tyrosine Kinase (Vascular Endothelial Growth Factor Receptor-1) in Pathological Angiogenesis

  Sachie Hiratsuka;Yoshiro Maru;Akiko Okada;Motoharu Seiki

  481
  Citations

• Activation of a recombinant membrane type 1-matrix metalloproteinase (MT1-MMP) by furin and its interaction with tissue inhibitor of metalloproteinases (TIMP)-2

  Hiroshi Sato;Takeshi Kinoshita;Takahisa Takino;Kazuo Nakayama

  467
  Citations

• Membrane-type matrix metalloproteinases.

  Motoharu Seiki

  441
  Citations

• Localization of matrix metalloproteinase 9 (92-kilodalton gelatinase/type IV collagenase = gelatinase B) in osteoclasts: implications for bone resorption.

  Y. Okada;K. Naka;K. Kawamura;T. Matsumoto

  429
  Citations