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Motoharu Seiki

Motoharu Seiki

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Biology and Biochemistry
Japan
2026

D-Index & Metrics

Biology and Biochemistry

D-Index
119
Citations
49620
World Ranking
676
National Ranking
29

Motoharu Seiki publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where Motoharu Seiki sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 414 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 849 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 950 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 841 scientists 207–216 publications: 735 scientists 217–226 publications: 709 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 418 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 197 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 60 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 399 publications — 90th percentile

90% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

Motoharu Seiki D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Motoharu Seiki sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 317 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 900 scientists 52–53 D-Index: 1,026 scientists 54–55 D-Index: 1,150 scientists 56–57 D-Index: 1,236 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,163 scientists 62–63 D-Index: 1,131 scientists 64–65 D-Index: 1,032 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 715 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 72 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 119 D-Index — 97th percentile

97% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in Japan Leader Award
  • 2025 - Research.com Biology and Biochemistry in Japan Leader Award
  • 2023 - Research.com Biology and Biochemistry in Japan Leader Award

Overview

Motoharu Seiki is affiliated with the University of Tokyo in Japan and has significant contributions across multiple fields within medical and molecular biology research.

Their research prominently spans the areas of Medicine and Biochemistry, Genetics and Molecular Biology. Within these domains, the subfields of Molecular Biology, Oncology, Epidemiology, Cancer Research, and Immunology have been central to their work. Key research topics include Cancer, Hypoxia, and Metabolism; Phagocytosis and Immune Regulation; Peptidase Inhibition and Analysis; Hepatitis B Virus Studies; SARS-CoV-2 and COVID-19 Research; Cell Adhesion Molecules Research; and Ubiquitin and proteasome pathways.

Recent publications by Motoharu Seiki reflect this broad scientific scope. Among these are:

  • Mint3 depletion restricts tumor malignancy of pancreatic cancer cells by decreasing SKP2 expression via HIF-1, 2020, Oncogene
  • Metalloproteinase-Dependent and TMPRSS2-Independent Cell Surface Entry Pathway of SARS-CoV-2 Requires the Furin Cleavage Site and the S2 Domain of Spike Protein, 2022, mBio
  • Serum Laminin γ2 Monomer as a Diagnostic and Predictive Biomarker for Hepatocellular Carcinoma, 2021, Hepatology
  • EXOSC9 depletion attenuates P-body formation, stress resistance, and tumorigenicity of cancer cells, 2020, Scientific Reports
  • Novel LAMC2 fusion protein has tumor-promoting properties in ovarian carcinoma, 2021, Cancer Science

The frequent co-authors collaborating with Motoharu Seiki include:

  • Naohiko Koshikawa
  • Takeharu Sakamoto
  • Jun-ichiro Inoue
  • Shuichi Kaneko
  • Taro Yamashita

Publication venues where Motoharu Seiki has regularly contributed include:

  • Scientific Reports
  • Cancer Science
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Oncogene
  • mBio

Best Publications

  • A matrix metalloproteinase expressed on the surface of invasive tumour cells

    Hiroshi Sato;Takahisa Takino;Yasunori Okada;Jian Cao

  • SR alpha promoter: an efficient and versatile mammalian cDNA expression system composed of the simian virus 40 early promoter and the R-U5 segment of human T-cell leukemia virus type 1 long terminal repeat.

    Y. Takebe;M. Seiki;J.-I. Fujisawa;P. Hoy

  • Human adult T-cell leukemia virus: complete nucleotide sequence of the provirus genome integrated in leukemia cell DNA.

    Motoharu Seiki;Seisuke Hattori;Yoko Hirayama;Mitsuaki Yoshida

  • Membrane Type 1 Matrix Metalloproteinase Digests Interstitial Collagens and Other Extracellular Matrix Macromolecules

    Eiko Ohuchi;Kazushi Imai;Yutaka Fujii;Hiroshi Sato

  • Monoclonal integration of human T-cell leukemia provirus in all primary tumors of adult T-cell leukemia suggests causative role of human T-cell leukemia virus in the disease.

    M Yoshida;M Seiki;K Yamaguchi;K Takatsuki

  • Membrane-Type 1 Matrix Metalloproteinase Cleaves Cd44 and Promotes Cell Migration

    Masahiro Kajita;Yoshifumi Itoh;Tadashige Chiba;Hidetoshi Mori

  • The membrane-anchored MMP inhibitor RECK is a key regulator of extracellular matrix integrity and angiogenesis.

    Junseo Oh;Rei Takahashi;Shunya Kondo;Akira Mizoguchi

  • Regulatory mechanism of 92 kDa type IV collagenase gene expression which is associated with invasiveness of tumor cells

    H Sato;M Seiki

  • Identification of the second membrane-type matrix metalloproteinase (MT-MMP-2) gene from a human placenta cDNA library. MT-MMPs form a unique membrane-type subclass in the MMP family.

    Takahisa Takino;Hiroshi Sato;Akira Shinagawa;Motoharu Seiki

  • Induction of interleukin 2 receptor gene expression by p40x encoded by human T-cell leukemia virus type 1.

    J Inoue;M Seiki;T Taniguchi;S Tsuru

  • MT1-MMP: a potent modifier of pericellular microenvironment.

    Yoshifumi Itoh;Motoharu Seiki

  • Transmembrane/cytoplasmic domain-mediated membrane type 1-matrix metalloprotease docking to invadopodia is required for cell invasion

    Hirokazu Nakahara;Linda Howard;Erik W. Thompson;Hiroshi Sato

  • Stimulation of 92-kDa gelatinase B promoter activity by ras is mitogen-activated protein kinase kinase 1-independent and requires multiple transcription factor binding sites including closely spaced PEA3/ets and AP-1 sequences.

    Rebecca Gum;Ernst Lengyel;Jose Juarez;Ji Hshiung Chen

  • Membrane-type 1 matrix metalloproteinase: a key enzyme for tumor invasion

    Motoharu Seiki

  • Homophilic complex formation of MT1-MMP facilitates proMMP-2 activation on the cell surface and promotes tumor cell invasion.

    Yoshifumi Itoh;Akiko Takamura;Noriko Ito;Yoshiro Maru

  • Evidence for aberrant activation of the interleukin-2 autocrine loop by HTLV-1-encoded p40x and T3/Ti complex triggering.

    Mitsuo Maruyama;Hiroshi Shibuya;Hisashi Harada;Masanori Hatakeyama

  • Involvement of Flt-1 Tyrosine Kinase (Vascular Endothelial Growth Factor Receptor-1) in Pathological Angiogenesis

    Sachie Hiratsuka;Yoshiro Maru;Akiko Okada;Motoharu Seiki

  • Activation of a recombinant membrane type 1-matrix metalloproteinase (MT1-MMP) by furin and its interaction with tissue inhibitor of metalloproteinases (TIMP)-2

    Hiroshi Sato;Takeshi Kinoshita;Takahisa Takino;Kazuo Nakayama

  • Membrane-type matrix metalloproteinases.

    Motoharu Seiki

  • Localization of matrix metalloproteinase 9 (92-kilodalton gelatinase/type IV collagenase = gelatinase B) in osteoclasts: implications for bone resorption.

    Y. Okada;K. Naka;K. Kawamura;T. Matsumoto

Frequent Co-Authors

Hiroshi Sato
Hiroshi Sato Kanazawa University
Naohiko Koshikawa
Naohiko Koshikawa Tokyo Institute of Technology
Yoshifumi Itoh
Yoshifumi Itoh University of Oxford
Yasunori Okada
Yasunori Okada Juntendo University
Mitsuaki Yoshida
Mitsuaki Yoshida University of Tokyo
Toshiro Hara
Toshiro Hara Kyushu University
Hideaki Nagase
Hideaki Nagase University of Oxford
Jun-ichiro Inoue
Jun-ichiro Inoue University of Tokyo
Yoshinori Murakami
Yoshinori Murakami University of Tokyo
Erik W. Thompson
Erik W. Thompson Queensland University of Technology

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