World's Best Scientists 2026 revealed!
Toshiro Hara

Toshiro Hara

D-Index & Metrics

Immunology

D-Index
76
Citations
25934
World Ranking
1874
National Ranking
72

Overview

Toshiro Hara is affiliated with Kyushu University in Japan and focuses research efforts primarily in the fields of Biochemistry, Genetics and Molecular Biology, and Medicine. Their work spans molecular biology, genetics, immunology, oncology, and cancer research, integrating multiple disciplines to explore mechanisms underlying cancer and immune responses.

The scientist's main topics of research include:

  • Single-cell and spatial transcriptomics
  • Glioma diagnosis and treatment
  • Immune cells in cancer
  • Cancer genomics and diagnostics
  • Cancer cells and metastasis
  • Cancer research and treatments
  • Neuroinflammation and neurodegeneration mechanisms

Frequent publication venues reflect the focus on neuro-oncology and cancer biology, with published work appearing in:

  • Neuro-Oncology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancer Cell
  • Cell
  • Neuro-Oncology Advances

Recent selected publications with Toshiro Hara as an author include:

  • Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma (2021, Cancer Cell)

Additionally, works often co-authored with collaborators such as Mario L. Suvà, Rony Chanoch-Myers, Itay Tirosh, Hiroaki Wakimoto, and Lillian Bussema reflect collaborative efforts across cancer and immunology research.

Other notable papers related to this research area, although authored by other researchers, indicate context and adjacent studies influencing the field:

  • Hallmarks of transcriptional intratumour heterogeneity across a thousand tumours (2023, Nature)
  • Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis (2021, Cell)
  • CTLA-4 blockade induces a microglia-Th1 cell partnership that stimulates microglia phagocytosis and anti-tumor function in glioblastoma (2023, Immunity)
  • DrugMap: A quantitative pan-cancer analysis of cysteine ligandability (2024, Cell)

The research attention on glioma and the tumor microenvironment is evidenced by recurring themes in both primary and co-authored work. Single-cell and spatial transcriptomics techniques are central to investigating cancer heterogeneity, immune interactions, and therapeutic responses.

Through these contributions, Toshiro Hara participates in advancing understanding of cancer biology at molecular and cellular levels, with a particular emphasis on glioblastoma and immune cell dynamics in tumors.

Best Publications

  • Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome

    Yoshiyuki Minegishi;Masako Saito;Shigeru Tsuchiya;Ikuya Tsuge

  • Human Tyrosine Kinase 2 Deficiency Reveals Its Requisite Roles in Multiple Cytokine Signals Involved in Innate and Acquired Immunity

    Yoshiyuki Minegishi;Masako Saito;Tomohiro Morio;Ken Watanabe

  • Efficacy of immunoglobulin plus prednisolone for prevention of coronary artery abnormalities in severe Kawasaki disease (RAISE study): a randomised, open-label, blinded-endpoints trial

    Tohru Kobayashi;Tsutomu Saji;Tetsuya Otani;Kazuo Takeuchi

  • Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma.

    Toshiro Hara;Rony Chanoch-Myers;Nathan D. Mathewson;Nathan D. Mathewson;Chad Myskiw

  • Clinical Features and Outcome of Patients With IRAK-4 and MyD88 Deficiency

    Capucine Picard;Capucine Picard;Horst Von Bernuth;Horst Von Bernuth;Horst Von Bernuth;Pegah Ghandil;Pegah Ghandil;Pegah Ghandil;Maya Chrabieh;Maya Chrabieh

  • Selective predisposition to bacterial infections in IRAK-4–deficient children: IRAK-4–dependent TLRs are otherwise redundant in protective immunity

    Cheng Lung Ku;Horst Von Bernuth;Horst Von Bernuth;Capucine Picard;Shen Ying Zhang

  • Human T cell activation. II. A new activation pathway used by a major T cell population via a disulfide-bonded dimer of a 44 kilodalton polypeptide (9.3 antigen).

    Toshiro Hara;Shu Man Fu;John A. Hansen

  • Smad2 and Smad3 Are Redundantly Essential for the TGF-β–Mediated Regulation of Regulatory T Plasticity and Th1 Development

    Tomohito Takimoto;Tomohito Takimoto;Yu Wakabayashi;Takashi Sekiya;Naoko Inoue

  • Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis

    Nathan D. Mathewson;Orr Ashenberg;Itay Tirosh;Simon Gritsch;Simon Gritsch

  • Molecular explanation for the contradiction between systemic Th17 defect and localized bacterial infection in hyper-IgE syndrome

    Yoshiyuki Minegishi;Masako Saito;Masayuki Nagasawa;Hidetoshi Takada

  • Cutting edge: Dominant effect of Ile50Val variant of the human IL-4 receptor α-chain in IgE synthesis

    Hiromichi Mitsuyasu;Yukiyoshi Yanagihara;Xiao Quan Mao;Pei Sun Gao

  • CD25+CD4+ T cells in human cord blood: an immunoregulatory subset with naive phenotype and specific expression of forkhead box p3 (Foxp3) gene.

    Yasushi Takahata;Akihiko Nomura;Hidetoshi Takada;Shouichi Ohga

  • Neutrophil-derived TNF-related apoptosis-inducing ligand (TRAIL): a novel mechanism of antitumor effect by neutrophils.

    Yuhki Koga;Akinobu Matsuzaki;Aiko Suminoe;Hiroyoshi Hattori;Hiroyoshi Hattori

  • A functional polymorphism in the promoter/enhancer region of the FOXP3/Scurfin gene associated with type 1 diabetes.

    Wafaa M. Bassuny;Kenji Ihara;Yuka Sasaki;Ryuichi Kuromaru

  • Association of CTLA‐4 but not CD28 gene polymorphisms with systemic lupus erythematosus in the Japanese population

    S. Ahmed;K. Ihara;S. Kanemitsu;H. Nakashima

  • Predominant activation and expansion of V gamma 9-bearing gamma delta T cells in vivo as well as in vitro in Salmonella infection.

    T Hara;Y Mizuno;K Takaki;H Takada

  • Human T cell activation. I. Monocyte-independent activation and proliferation induced by anti-T3 monoclonal antibodies in the presence of tumor promoter 12-o-tetradecanoyl phorbol-13 acetate.

    Toshiro Hara;Shu Man Fu

  • A functional polymorphism in fas (CD95/APO-1) gene promoter associated with systemic lupus erythematosus.

    Satomi Kanemitsu;Kenji Ihara;Ahmed Saifddin;Takeshi Otsuka

  • Detection and functional studies of p60-65 (Tac antigen) on activated human B cells.

    Lawrence K. L. Jung;Toshiro Hara;Shu Man Fu

  • Association of vascular endothelial growth factor (VEGF) and VEGF receptor gene polymorphisms with coronary artery lesions of Kawasaki disease.

    Hidehiko Kariyazono;Takuro Ohno;Vahid Khajoee;Kenji Ihara

Frequent Co-Authors

Shouichi Ohga
Shouichi Ohga Kyushu University
Motoharu Seiki
Motoharu Seiki University of Tokyo
Koichi Ohshima
Koichi Ohshima Kurume University
Shigeaki Nonoyama
Shigeaki Nonoyama National Defense Medical College
Yoshinao Oda
Yoshinao Oda Kyushu University
Dongchon Kang
Dongchon Kang Kyushu University
Hirotomo Saitsu
Hirotomo Saitsu Hamamatsu University
Hirokazu Kanegane
Hirokazu Kanegane Tokyo Medical and Dental University
Naomichi Matsumoto
Naomichi Matsumoto Yokohama City University
Yoshinori Murakami
Yoshinori Murakami University of Tokyo

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

For students interested in Immunology, exploring related healthcare fields can broaden career options. Nursing, especially advanced practice roles, often intersect with immunological knowledge. Many professionals choose to enhance their credentials by pursuing nurse practitioner programs. If you're looking for programs that are manageable alongside other commitments, consider the what is the easiest np program to find the best fit for your needs.

Mental health is a growing area with increasing demand, and specialized training is crucial. Aspiring psychiatric nurse practitioners should look into top programs that facilitate clinical experiences to build competence. The best psychiatric mental health nurse practitioner programs online offer strong clinical placement rates to support this.

Cost is often a deciding factor. Thankfully, there are affordable online programs that provide quality education without the hefty price tag. Exploring the cheapest pmhnp programs online can help candidates access crucial training while minimizing debt.

Understanding potential earnings after graduation is equally important. Nurse practitioners, particularly those holding a Doctor of Nursing Practice (DNP), can expect varying salaries depending on location. Reviewing data on dnp salary by state offers valuable insight for planning a career that aligns with your financial goals.

Best Scientists Citing Toshiro Hara

Trending Scientists