World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
44
Citations
7689
World Ranking
19277
National Ranking
1391

Overview

Naohiko Koshikawa is affiliated with the Tokyo Institute of Technology in Japan and works primarily in the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Their research spans key subfields including Molecular Biology, Oncology, Cell Biology, Surgery, and Infectious Diseases.

The scientist's work covers a diverse range of topics such as Cell Adhesion Molecules Research, SARS-CoV-2 and COVID-19 Research, Phagocytosis and Immune Regulation, Monoclonal and Polyclonal Antibodies Research, Glycosylation and Glycoproteins Research, Peptidase Inhibition and Analysis, and Signaling Pathways in Disease.

Recent papers authored or co-authored by Naohiko Koshikawa include:

  • Metalloproteinase-Dependent and TMPRSS2-Independent Cell Surface Entry Pathway of SARS-CoV-2 Requires the Furin Cleavage Site and the S2 Domain of Spike Protein, 2022, mBio
  • Serum Laminin γ2 Monomer as a Diagnostic and Predictive Biomarker for Hepatocellular Carcinoma, 2021, Hepatology
  • Novel LAMC2 fusion protein has tumor-promoting properties in ovarian carcinoma, 2021, Cancer Science
  • Expression of Cancer Stem Cell Markers EpCAM and CD90 Is Correlated with Anti- and Pro-Oncogenic EphA2 Signaling in Hepatocellular Carcinoma, 2021, International Journal of Molecular Sciences
  • NH2-terminal fragment of ZF21 protein suppresses tumor invasion via inhibiting the interaction of ZF21 with FAK, 2020, Cancer Science

The scientist frequently publishes in the following venues:

  • Cancer Science (4 publications)
  • Scientific Reports (2 publications)
  • mBio (1 publication)
  • Hepatology (1 publication)
  • International Journal of Molecular Sciences (1 publication)

Naohiko Koshikawa collaborates often with these co-authors:

  • Motoharu Seiki (9 joint publications)
  • Taro Yamashita (7 joint publications)
  • Toru Yoshimura (6 joint publications)
  • Takeshi Terashima (5 joint publications)
  • Masatoshi Nakagawa (5 joint publications)

Best Publications

  • Role of Cell Surface Metalloprotease Mt1-Mmp in Epithelial Cell Migration over Laminin-5

    Naohiko Koshikawa;Naohiko Koshikawa;Gianluigi Giannelli;Vincenzo Cirulli;Kaoru Miyazaki

  • Cooperative interactions of laminin 5 gamma2 chain, matrix metalloproteinase-2, and membrane type-1-matrix/metalloproteinase are required for mimicry of embryonic vasculogenesis by aggressive melanoma.

    Richard E. B. Seftor;Elisabeth A. Seftor;Naohiko Koshikawa;Paul S. Meltzer

  • CD44 directs membrane‐type 1 matrix metalloproteinase to lamellipodia by associating with its hemopexin‐like domain

    Hidetoshi Mori;Taizo Tomari;Naohiko Koshikawa;Masahiro Kajita

  • Binding to EGF receptor of a laminin-5 EGF-like fragment liberated during MMP-dependent mammary gland involution

    Susann Schenk;Edith Hintermann;Martin Bilban;Naohiko Koshikawa

  • Turnover of Focal Adhesions and Cancer Cell Migration

    Makoto Nagano;Daisuke Hoshino;Naohiko Koshikawa;Toshifumi Akizawa

  • Overexpression of Laminin γ2 Chain Monomer in Invading Gastric Carcinoma Cells

    Naohiko Koshikawa;Kayano Moriyama;Hiroyuki Takamura;Hiroto Mizushima

  • Expression of Trypsin by Epithelial Cells of Various Tissues, Leukocytes, and Neurons in Human and Mouse

    Naohiko Koshikawa;Satoshi Hasegawa;Satoshi Hasegawa;Yoji Nagashima;Keisuke Mitsuhashi

  • Cleavage of metastasis suppressor gene product KiSS-1 protein/metastin by matrix metalloproteinases.

    Takahisa Takino;Naohiko Koshikawa;Hisashi Miyamori;Motohiro Tanaka

  • Expression of gelatinase A, tissue inhibitor of metalloproteinases-2, matrilysin, and trypsin(ogen) in lung neoplasms : An immunohistochemical study

    Naomi Kawano;Hiroyuki Osawa;Takaaki Ito;Yoji Nagashima

  • Multiple secretion of matrix serine proteinases by human gastric carcinoma cell lines.

    Naohiko Koshikawa;Hidetaro Yasumitsu;Makoto Umeda;Kaoru Miyazaki

  • Trypsin Stimulates Integrin α5β1-dependent Adhesion to Fibronectin and Proliferation of Human Gastric Carcinoma Cells through Activation of Proteinase-activated Receptor-2 *

    Satoshi Miyata;Satoshi Miyata;Naohiko Koshikawa;Hidetaro Yasumitsu;Hidetaro Yasumitsu;Kaoru Miyazaki;Kaoru Miyazaki

  • Membrane Type 1 Matrix Metalloproteinase (MT1-MMP/MMP-14) Cleaves and Releases a 22-kDa Extracellular Matrix Metalloproteinase Inducer (EMMPRIN) Fragment from Tumor Cells

    Nagayasu Egawa;Naohiko Koshikawa;Taizo Tomari;Kazuki Nabeshima

  • cDNA cloning and mRNA expression of a serine proteinase inhibitor secreted by cancer cells: identification as placental protein 5 and tissue factor pathway inhibitor-2.

    Yohei Miyagi;Naohiko Koshikawa;Hidetaro Yasumitsu;Etsuko Miyagi

  • Membrane-type matrix metalloproteinase-1 (MT1-MMP) is a processing enzyme for human laminin γ2 chain

    Naohiko Koshikawa;Tomoko Minegishi;Andrew Sharabi;Vito Quaranta;Vito Quaranta

  • Wide distribution of laminin-5 gamma 2 chain in basement membranes of various human tissues.

    Hiroto Mizushima;Naohiko Koshikawa;Kayano Moriyama;Hiroyuki Takamura

  • Matrix metalloproteinases process the laminin-5 γ2-chain and regulate epithelial cell migration

    Emma Pirilä;Andrew Sharabi;Tuula Salo;Vito Quaranta

  • Expression of trypsin in vascular endothelial cells

    Naohiko Koshikawa;Yoji Nagashima;Yohei Miyagi;Hiroto Mizushima

  • Matrilysin‐specific antisense oligonucleotide inhibits liver metastasis of human colon cancer cells in a nude mouse model

    Satoshi Hasegawa;Naohiko Koshikawa;Nobuyoshi Momiyama;Kayano Moriyama

  • Matrilysin (MMP-7) induces homotypic adhesion of human colon cancer cells and enhances their metastatic potential in nude mouse model

    Mitomu Kioi;Kazuhiro Yamamoto;Shouichi Higashi;Naohiko Koshikawa

  • The LG3 Module of Laminin-5 Harbors a Binding Site for Integrin α3β1 That Promotes Cell Adhesion, Spreading, and Migration

    Meiling Shang;Naohiko Koshikawa;Susann Schenk;Vito Quaranta

Frequent Co-Authors

Motoharu Seiki
Motoharu Seiki University of Tokyo
Kaoru Miyazaki
Kaoru Miyazaki Yokohama City University
Vito Quaranta
Vito Quaranta Vanderbilt University
Ambra Pozzi
Ambra Pozzi Vanderbilt University Medical Center
Hiromitsu Nakauchi
Hiromitsu Nakauchi Stanford University
Roy Zent
Roy Zent Vanderbilt University Medical Center
Toshiaki Isobe
Toshiaki Isobe Tokyo Metropolitan University
Yoshifumi Itoh
Yoshifumi Itoh University of Oxford
Mamoru Watanabe
Mamoru Watanabe Tokyo Medical and Dental University
Eisuke Mekada
Eisuke Mekada Osaka University

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