Eisuke Mekada

Overview

Best Publications

• One molecule of diphtheria toxin fragment A introduced into a cell can kill the cell.

  Masaru Yamaizumi;Eisuke Mekada;Tsuyoshi Uchida;Yoshio Okada

  1030
  Citations

• Requirement of CD9 on the egg plasma membrane for fertilization.

  Kenji Miyado;Gen Yamada;Shuichi Yamada;Hidetoshi Hasuwa

  836
  Citations

• A metalloprotease-disintegrin, MDC9/meltrin-gamma/ADAM9 and PKCdelta are involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor.

  Yasushi Izumi;Michinari Hirata;Hidetoshi Hasuwa;Ryo Iwamoto;Ryo Iwamoto

  659
  Citations

• Diphtheria toxin receptor-mediated conditional and targeted cell ablation in transgenic mice

  Michiko Saito;Takao Iwawaki;Choji Taya;Hiromichi Yonekawa

  563
  Citations

• Diphtheria Toxin Binds to the Epidermal Growth Factor (EGF)-like Domain of Human Heparin-binding EGF-like Growth Factor/Diphtheria Toxin Receptor and Inhibits Specifically Its Mitogenic Activity

  Toshihide Mitamura;Shigeki Higashiyama;Naoyuki Taniguchi;Michael Klagsbrun

  429
  Citations

• Heparin-binding EGF-like growth factor and ErbB signaling is essential for heart function

  Ryo Iwamoto;Satoru Yamazaki;Masanori Asakura;Seiji Takashima

  419
  Citations

• Heparin-binding EGF-like growth factor accelerates keratinocyte migration and skin wound healing

  Yuji Shirakata;Rina Kimura;Daisuke Nanba;Ryo Iwamoto

  407
  Citations

• Heparin-binding EGF-like growth factor, which acts as the diphtheria toxin receptor, forms a complex with membrane protein DRAP27/CD9, which up-regulates functional receptors and diphtheria toxin sensitivity

  R. Iwamoto;S. Higashiyama;T. Mitamura;N. Taniguchi

  370
  Citations

• The membrane protein CD9/DRAP 27 potentiates the juxtacrine growth factor activity of the membrane-anchored heparin-binding EGF-like growth factor.

  S Higashiyama;R Iwamoto;K Goishi;G Raab

  363
  Citations

• Membrane-anchored heparin-binding EGF-like growth factor (HB-EGF) and diphtheria toxin receptor-associated protein (DRAP27)/CD9 form a complex with integrin alpha 3 beta 1 at cell-cell contact sites.

  Kuniaki Nakamura;Ryo Iwamoto;Eisuke Mekada

  350
  Citations

• Phorbol ester induces the rapid processing of cell surface heparin-binding EGF-like growth factor: conversion from juxtacrine to paracrine growth factor activity.

  K Goishi;S Higashiyama;M Klagsbrun;N Nakano

  336
  Citations

• Heparin-binding EGF-like growth factor: a juxtacrine growth factor.

  Ryo Iwamoto;Eisuke Mekada

  293
  Citations

• Heparin-binding EGF-like growth factor is a promising target for ovarian cancer therapy

  Shingo Miyamoto;Michinari Hirata;Ayano Yamazaki;Takuya Kageyama

  284
  Citations

• Ligand-independent Dimer Formation of Epidermal Growth Factor Receptor (EGFR) Is a Step Separable from Ligand-induced EGFR Signaling

  Xiaochun Yu;Kailash D. Sharma;Tsuyoshi Takahashi;Ryo Iwamoto

  273
  Citations

• The cytotoxic action of diphtheria toxin and its degradation in intact Vero cells are inhibited by bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase.

  T Umata;Y Moriyama;M Futai;E Mekada

  228
  Citations

• Tetraspanins CD9 and CD81 function to prevent the fusion of mononuclear phagocytes

  Yoshito Takeda;Isao Tachibana;Kenji Miyado;Masatoshi Kobayashi

  219
  Citations

• Clinical significance of heparin-binding epidermal growth factor- like growth factor and a disintegrin and metalloprotease 17 expression in human ovarian cancer

  Yoshihiro Tanaka;Shingo Miyamoto;Satoshi O. Suzuki;Eiji Oki

  216
  Citations

• The fusing ability of sperm is bestowed by CD9-containing vesicles released from eggs in mice

  Kenji Miyado;Keiichi Yoshida;Kazuo Yamagata;Keiichi Sakakibara

  215
  Citations

• Mice with defects in HB-EGF ectodomain shedding show severe developmental abnormalities

  Satoru Yamazaki;Ryo Iwamoto;Kazuko Saeki;Masanori Asakura

  213
  Citations

• Heparin-binding epidermal growth factor-like growth factor as a novel targeting molecule for cancer therapy

  Shingo Miyamoto;Hiroshi Yagi;Fusanori Yotsumoto;Tatsuhiko Kawarabayashi

  206
  Citations