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D-Index & Metrics

Biology and Biochemistry

D-Index
56
Citations
8770
World Ranking
14664
National Ranking
6134

Overview

John R. Murphy is affiliated with Johns Hopkins University in the United States. Their research spans multiple intersecting fields primarily within Medicine, Biochemistry, Genetics and Molecular Biology, and Immunology and Microbiology. Notably, their focused subfields include Immunology, Genetics, Molecular Biology, Surgery, and Infectious Diseases.

The scientist's recent publications reflect a concentration on immune function, cancer biology, infectious disease, and craniofacial disorders. Key recent papers include:

  • Glutamine metabolism inhibition has dual immunomodulatory and antibacterial activities against Mycobacterium tuberculosis (2023) published in Nature Communications
  • Therapeutic targeting with DABIL-4 depletes myeloid suppressor cells in 4T1 triple-negative breast cancer model (2021) published in Molecular Oncology
  • Metabolic abnormalities in G6PC3-deficient human neutrophils result in severe functional defects (2020) published in Blood Advances
  • In vivo interferon-gamma induced changes in gene expression dramatically alter neutrophil phenotype (2022) published in PLoS ONE
  • From Augmented to Virtual Reality in Plastic Surgery: Blazing the Trail to a New Frontier (2023) published in Journal of Reconstructive Microsurgery

Their collaborative work often involves frequent co-authors such as:

  • Sadiya Parveen
  • William R. Bishai
  • Kaamya Varagur
  • Jessica Shen
  • Shichun Lun

John R. Murphy's research contributions have been disseminated through several notable publication venues. Frequent venues include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • The Cleft Palate-Craniofacial Journal
  • Nature Communications
  • Molecular Oncology
  • Blood Advances

The main topics they investigate include immune cells in cancer, cleft lip and palate research, craniofacial disorders and treatments, tuberculosis research and epidemiology, immune response and inflammation, Pneumocystis jirovecii pneumonia detection and treatment, and cancer therapeutics and mechanisms. These topical areas indicate a broad engagement with immunological mechanisms in both infectious disease and cancer, alongside specialized work in craniofacial medical research.

Best Publications

  • Diphtheria toxin receptor binding domain substitution with interleukin-2: genetic construction and properties of a diphtheria toxin-related interleukin-2 fusion protein

    D.P. Williams;K. Parker;P. Bacha;W. Bishai;W. Bishai

  • Molecular cloning and DNA sequence analysis of a diphtheria tox iron-dependent regulatory element (dtxR) from Corynebacterium diphtheriae.

    Jessica Boyd;Manish N. Oza;John R. Murphy

  • Interleukin 2 receptor-targeted cytotoxicity. Interleukin 2 receptor-mediated action of a diphtheria toxin-related interleukin 2 fusion protein.

    P Bacha;D P Williams;C Waters;J M Williams

  • Structure/function analysis of interleukin-2-toxin (DAB486-IL-2) : fragment B sequences required for the delivery of fragment A to the cytosol of target cells

    D P Williams;C E Snider;T B Strom;J R Murphy

  • Structure of the metal-ion-activated diphtheria toxin repressor/ tox operator complex

    André White;Xiaochun Ding;Johanna C. vanderSpek;John R. Murphy

  • Developmental and adult phenotyping directly from mutant embryonic stem cells.

    Sophia H. L. George;Marina Gertsenstein;Kristina Vintersten;Ella Korets-Smith

  • The cytosolic entry of diphtheria toxin catalytic domain requires a host cell cytosolic translocation factor complex.

    Ryan Ratts;Huiyan Zeng;Eric A. Berg;Clare Blue

  • Genetic construction, expression, and melanoma-selective cytotoxicity of a diphtheria toxin-related alpha-melanocyte-stimulating hormone fusion protein.

    John R. Murphy;William Bishai;Marianne Borowski;Atsushi Miyanohara

  • Chronic lymphocytic leukemic (CLL) cells secrete multispecific autoantibodies.

    Barbara M. Bröker;Adek Klajman;Pierre Youinou;Jean Jouquan

  • Regulation of human metabolism by hypoxia-inducible factor

    Federico Formenti;Dumitru Constantin-Teodosiu;Yaso Emmanuel;Jane Cheeseman

  • Mechanism of diphtheria toxin catalytic domain delivery to the eukaryotic cell cytosol and the cellular factors that directly participate in the process.

    John R. Murphy

  • Abnormal distribution of the helper-inducer and suppressor-inducer T-lymphocyte subsets in the rheumatoid joint.

    Costantino Pitzalis;Gabrielle Kingsley;John Murphy;Gabriel Panayi

  • Iron, DtxR, and the regulation of diphtheria toxin expression

    Xu Tao;Nikolaus Schiering;Hui‐yan Zeng;Dagmar Ringe

  • MEMBRANE TRANSLOCATION OF DIPHTHERIA TOXIN FRAGMENT A EXPLOITS EARLY TO LATE ENDOSOME TRAFFICKING MACHINERY

    E Lemichez;M Bomsel;G Devilliers;J vanderSpek

  • Nucleotide sequence and expression of the diphtheria tox228 gene in Escherichia coli

    Michel Kaczorek;Francis Delpeyroux;Nicole Chenciner;Rolf E. Streeck

  • STUDIES ON THE MOLECULAR EPIDEMIOLOGY OF DIPHTHERIA

    A.M. Pappenheimer;JohnR. Murphy

  • Interleukin 2 receptor-targeted cytotoxicity. Receptor binding requirements for entry of a diphtheria toxin-related interleukin 2 fusion protein into cells.

    Cory A. Waters;Patricia A. Schimke;Catherine E. Snider;Kyogo Itoh

  • Attenuation of virulence in Mycobacterium tuberculosis expressing a constitutively active iron repressor

    Yukari C. Manabe;Beatrice J. Saviola;Li Sun;John R. Murphy

  • Structures of the apo- and the metal ion-activated forms of the diphtheria tox repressor from Corynebacterium diphtheriae

    Nikolaus Schiering;Xu Tao;Huiyan Zeng;John R. Murphy

  • Binding of the metalloregulatory protein DtxR to the diphtheria tox operator requires a divalent heavy metal ion and protects the palindromic sequence from DNase I digestion.

    Xu Tao;J. R. Murphy

Frequent Co-Authors

William R. Bishai
William R. Bishai Johns Hopkins University
Terry B. Strom
Terry B. Strom Beth Israel Deaconess Medical Center
Yukari C. Manabe
Yukari C. Manabe Johns Hopkins University School of Medicine
Dagmar Ringe
Dagmar Ringe Brandeis University
Philippe Leboulch
Philippe Leboulch Brigham and Women's Hospital
Andras Nagy
Andras Nagy Lunenfeld-Tanenbaum Research Institute
Patrice Boquet
Patrice Boquet Grenoble Alpes University
Jody J. Haigh
Jody J. Haigh University of Manitoba
Zilong Wen
Zilong Wen Hong Kong University of Science and Technology
John J. Mekalanos
John J. Mekalanos Harvard Medical School

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