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Shigeki Higashiyama

Shigeki Higashiyama

Ehime University
Japan

D-Index & Metrics

Biology and Biochemistry

D-Index
82
Citations
24054
World Ranking
3699
National Ranking
236

Shigeki Higashiyama publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where Shigeki Higashiyama sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 413 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 848 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 949 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 840 scientists 207–216 publications: 733 scientists 217–226 publications: 708 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 417 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 196 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 59 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 333 publications — 83rd percentile

83% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

Shigeki Higashiyama D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Shigeki Higashiyama sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 316 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 899 scientists 52–53 D-Index: 1,025 scientists 54–55 D-Index: 1,149 scientists 56–57 D-Index: 1,235 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,162 scientists 62–63 D-Index: 1,130 scientists 64–65 D-Index: 1,031 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 714 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 71 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 82 D-Index — 82nd percentile

82% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Overview

Shigeki Higashiyama is affiliated with Ehime University in Japan and has contributed to research primarily within the field of Medicine, focusing extensively on Radiology, Nuclear Medicine and Imaging. Their scholarly outputs span several subfields including Pulmonary and Respiratory Medicine, Biomedical Engineering, Hepatology, and Epidemiology.

The scientist's research concentrates on topics such as Radiomics and Machine Learning in Medical Imaging, Medical Imaging Techniques and Applications, Medical Imaging and Pathology Studies, Medical Imaging and Analysis, Liver Disease Diagnosis and Treatment, Liver Disease and Transplantation, and Radiation Dose and Imaging.

Recent publications by Shigeki Higashiyama include:

  • "Deep learning-based detection of parathyroid adenoma by 99mTc-MIBI scintigraphy in patients with primary hyperparathyroidism" (2022) in Annals of Nuclear Medicine
  • "Short-term hepatocyte function and portal hypertension outcomes of sofosbuvir/velpatasvir for decompensated hepatitis C-related cirrhosis" (2023) in Journal of Gastroenterology
  • "Study of the Usefulness of Bone Scan Index Calculated From 99m-Technetium-Hydroxymethylene Diphosphonate (99mTc-HMDP) Bone Scintigraphy for Bone Metastases from Prostate Cancer Using Deep Learning Algorithms" (2020) in Current Medical Imaging Formerly Current Medical Imaging Reviews
  • "Assessment of a software for semi-automatically calculating the bone scan index on bone scintigraphy scans" (2021) in Clinical Imaging
  • "Extraction of metastasis hotspots in a whole-body bone scintigram based on bilateral asymmetry" (2021) in International Journal of Computer Assisted Radiology and Surgery

The most frequent publication venues where their work appears are:

  • International Journal of Computer Assisted Radiology and Surgery
  • Annals of Nuclear Medicine
  • Journal of Gastroenterology
  • Current Medical Imaging Formerly Current Medical Imaging Reviews
  • Clinical Imaging

Shigeki Higashiyama collaborates regularly with several researchers, including Joji Kawabe, Atsushi Yoshida, Takashi Yamanaga, Akinobu Shimizu, and Yukio Miki, with joint publications numbering up to 14 with the most frequent coauthor.

Best Publications

  • A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF.

    Shigeki Higashiyama;Judith A. Abraham;Judy Miller;John C. Fiddes

  • Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands

    Umut Sahin;Gisela Weskamp;Kristine Kelly;Kristine Kelly;Hong-Ming Zhou

  • Cardiac hypertrophy is inhibited by antagonism of ADAM12 processing of HB-EGF: Metalloproteinase inhibitors as a new therapy

    Masanori Asakura;Masafumi Kitakaze;Seiji Takashima;Yulin Liao

  • Heparin-binding EGF-like growth factor stimulation of smooth muscle cell migration: dependence on interactions with cell surface heparan sulfate

    Shigeki Higashiyama;Judith A. Abraham;Michael Klagsbrun

  • Appearance of heparin-binding EGF-like growth factor in wound fluid as a response to injury.

    Moshe Marikovsky;Karl Breuing;Paul Yu Liu;Elof Eriksson

  • Induction of Keratinocyte Migration via Transactivation of the Epidermal Growth Factor Receptor by the Antimicrobial Peptide LL-37

    Sho Tokumaru;Koji Sayama;Yuji Shirakata;Hitoshi Komatsuzawa

  • TGFα shedding assay: an accurate and versatile method for detecting GPCR activation

    Asuka Inoue;Jun Ishiguro;Hajime Kitamura;Naoaki Arima

  • Specific Molecular Interactions of Oversulfated Chondroitin Sulfate E with Various Heparin-binding Growth Factors IMPLICATIONS AS A PHYSIOLOGICAL BINDING PARTNER IN THE BRAIN AND OTHER TISSUES

    Sarama Sathyaseelan Deepa;Yuko Umehara;Shigeki Higashiyama;Nobuyuki Itoh

  • Diphtheria Toxin Binds to the Epidermal Growth Factor (EGF)-like Domain of Human Heparin-binding EGF-like Growth Factor/Diphtheria Toxin Receptor and Inhibits Specifically Its Mitogenic Activity

    Toshihide Mitamura;Shigeki Higashiyama;Naoyuki Taniguchi;Michael Klagsbrun

  • Heparin-binding EGF-like growth factor and ErbB signaling is essential for heart function

    Ryo Iwamoto;Satoru Yamazaki;Masanori Asakura;Seiji Takashima

  • Heparin-binding EGF-like growth factor accelerates keratinocyte migration and skin wound healing

    Yuji Shirakata;Rina Kimura;Daisuke Nanba;Ryo Iwamoto

  • The Integrin α9β1 Binds to a Novel Recognition Sequence (SVVYGLR) in the Thrombin-cleaved Amino-terminal Fragment of Osteopontin

    Yasuyuki Yokosaki;Nariaki Matsuura;Tomohiro Sasaki;Isao Murakami

  • Expression and clinical significance of erb-B receptor family in hepatocellular carcinoma.

    Y Ito;T Takeda;M Sakon;M Tsujimoto

  • Heparin-binding EGF-like growth factor, which acts as the diphtheria toxin receptor, forms a complex with membrane protein DRAP27/CD9, which up-regulates functional receptors and diphtheria toxin sensitivity

    R. Iwamoto;S. Higashiyama;T. Mitamura;N. Taniguchi

  • Ectodomain Shedding of Epidermal Growth Factor Receptor Ligands Is Required for Keratinocyte Migration in Cutaneous Wound Healing

    Sho Tokumaru;Sho Tokumaru;Shigeki Higashiyama;Takeshi Endo;Takatoshi Nakagawa

  • The membrane protein CD9/DRAP 27 potentiates the juxtacrine growth factor activity of the membrane-anchored heparin-binding EGF-like growth factor.

    S Higashiyama;R Iwamoto;K Goishi;G Raab

  • Phorbol ester induces the rapid processing of cell surface heparin-binding EGF-like growth factor: conversion from juxtacrine to paracrine growth factor activity.

    K Goishi;S Higashiyama;M Klagsbrun;N Nakano

  • Membrane-anchored growth factors, the epidermal growth factor family : Beyond receptor ligands

    Shigeki Higashiyama;Hidehiko Iwabuki;Chie Morimoto;Miki Hieda

  • Isolation and characterization of a macrophage-derived heparin-binding growth factor.

    G Besner;S Higashiyama;M Klagsbrun

  • HB-EGF is a potent inducer of tumor growth and angiogenesis.

    Pat P. Ongusaha;Jennifer C. Kwak;Andrew J. Zwible;Salvador Macip

Frequent Co-Authors

Naoyuki Taniguchi
Naoyuki Taniguchi Osaka University
Yuji Matsuzawa
Yuji Matsuzawa Sumitomo Hospital
Koji Hashimoto
Koji Hashimoto Ehime University
Eisuke Mekada
Eisuke Mekada Osaka University
Yasuhisa Shinomura
Yasuhisa Shinomura Sapporo Medical University
Yann Barrandon
Yann Barrandon École Polytechnique Fédérale de Lausanne
Michael Klagsbrun
Michael Klagsbrun Boston Children's Hospital
Masatsugu Hori
Masatsugu Hori Osaka University
Nobuyuki Takei
Nobuyuki Takei Niigata University
Hiroyuki Nawa
Hiroyuki Nawa Wakayama Medical University

External Links

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Best Scientists Citing Shigeki Higashiyama

Carl P. Blobel

Carl P. Blobel

Cornell University

Publications: 96

Junken Aoki

Junken Aoki

Tohoku University

Publications: 73

Asuka Inoue

Asuka Inoue

Tohoku University

Publications: 68

Eisuke Mekada

Eisuke Mekada

Osaka University

Publications: 64

Naoyuki Taniguchi

Naoyuki Taniguchi

Osaka University

Publications: 62

Kazuyuki Sugahara

Kazuyuki Sugahara

Hokkaido University

Publications: 55

Michael Klagsbrun

Michael Klagsbrun

Boston Children's Hospital

Publications: 36

Peter J. Dempsey

Peter J. Dempsey

University of Colorado Denver

Publications: 33

Paul Saftig

Paul Saftig

Kiel University

Publications: 30

Douglas A. Lauffenburger

Douglas A. Lauffenburger

MIT

Publications: 27

Raymond C. Harris

Raymond C. Harris

Vanderbilt University Medical Center

Publications: 26

Robert J. Coffey

Robert J. Coffey

Vanderbilt University Medical Center

Publications: 26

Ulla M. Wewer

Ulla M. Wewer

University of Copenhagen

Publications: 26

Dean Sheppard

Dean Sheppard

University of California, San Francisco

Publications: 24

Hiroyuki Nawa

Hiroyuki Nawa

Wakayama Medical University

Publications: 24

Yasunori Okada

Yasunori Okada

Juntendo University

Publications: 24

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