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Shigeki Higashiyama

Shigeki Higashiyama

D-Index & Metrics

Biology and Biochemistry

D-Index
82
Citations
24054
World Ranking
3700
National Ranking
236

Overview

Shigeki Higashiyama is affiliated with Ehime University in Japan and has contributed to research primarily within the field of Medicine, focusing extensively on Radiology, Nuclear Medicine and Imaging. Their scholarly outputs span several subfields including Pulmonary and Respiratory Medicine, Biomedical Engineering, Hepatology, and Epidemiology.

The scientist's research concentrates on topics such as Radiomics and Machine Learning in Medical Imaging, Medical Imaging Techniques and Applications, Medical Imaging and Pathology Studies, Medical Imaging and Analysis, Liver Disease Diagnosis and Treatment, Liver Disease and Transplantation, and Radiation Dose and Imaging.

Recent publications by Shigeki Higashiyama include:

  • "Deep learning-based detection of parathyroid adenoma by 99mTc-MIBI scintigraphy in patients with primary hyperparathyroidism" (2022) in Annals of Nuclear Medicine
  • "Short-term hepatocyte function and portal hypertension outcomes of sofosbuvir/velpatasvir for decompensated hepatitis C-related cirrhosis" (2023) in Journal of Gastroenterology
  • "Study of the Usefulness of Bone Scan Index Calculated From 99m-Technetium-Hydroxymethylene Diphosphonate (99mTc-HMDP) Bone Scintigraphy for Bone Metastases from Prostate Cancer Using Deep Learning Algorithms" (2020) in Current Medical Imaging Formerly Current Medical Imaging Reviews
  • "Assessment of a software for semi-automatically calculating the bone scan index on bone scintigraphy scans" (2021) in Clinical Imaging
  • "Extraction of metastasis hotspots in a whole-body bone scintigram based on bilateral asymmetry" (2021) in International Journal of Computer Assisted Radiology and Surgery

The most frequent publication venues where their work appears are:

  • International Journal of Computer Assisted Radiology and Surgery
  • Annals of Nuclear Medicine
  • Journal of Gastroenterology
  • Current Medical Imaging Formerly Current Medical Imaging Reviews
  • Clinical Imaging

Shigeki Higashiyama collaborates regularly with several researchers, including Joji Kawabe, Atsushi Yoshida, Takashi Yamanaga, Akinobu Shimizu, and Yukio Miki, with joint publications numbering up to 14 with the most frequent coauthor.

Best Publications

  • A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF.

    Shigeki Higashiyama;Judith A. Abraham;Judy Miller;John C. Fiddes

  • Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands

    Umut Sahin;Gisela Weskamp;Kristine Kelly;Kristine Kelly;Hong-Ming Zhou

  • Cardiac hypertrophy is inhibited by antagonism of ADAM12 processing of HB-EGF: Metalloproteinase inhibitors as a new therapy

    Masanori Asakura;Masafumi Kitakaze;Seiji Takashima;Yulin Liao

  • Heparin-binding EGF-like growth factor stimulation of smooth muscle cell migration: dependence on interactions with cell surface heparan sulfate

    Shigeki Higashiyama;Judith A. Abraham;Michael Klagsbrun

  • Appearance of heparin-binding EGF-like growth factor in wound fluid as a response to injury.

    Moshe Marikovsky;Karl Breuing;Paul Yu Liu;Elof Eriksson

  • Induction of Keratinocyte Migration via Transactivation of the Epidermal Growth Factor Receptor by the Antimicrobial Peptide LL-37

    Sho Tokumaru;Koji Sayama;Yuji Shirakata;Hitoshi Komatsuzawa

  • TGFα shedding assay: an accurate and versatile method for detecting GPCR activation

    Asuka Inoue;Jun Ishiguro;Hajime Kitamura;Naoaki Arima

  • Specific Molecular Interactions of Oversulfated Chondroitin Sulfate E with Various Heparin-binding Growth Factors IMPLICATIONS AS A PHYSIOLOGICAL BINDING PARTNER IN THE BRAIN AND OTHER TISSUES

    Sarama Sathyaseelan Deepa;Yuko Umehara;Shigeki Higashiyama;Nobuyuki Itoh

  • Diphtheria Toxin Binds to the Epidermal Growth Factor (EGF)-like Domain of Human Heparin-binding EGF-like Growth Factor/Diphtheria Toxin Receptor and Inhibits Specifically Its Mitogenic Activity

    Toshihide Mitamura;Shigeki Higashiyama;Naoyuki Taniguchi;Michael Klagsbrun

  • Heparin-binding EGF-like growth factor and ErbB signaling is essential for heart function

    Ryo Iwamoto;Satoru Yamazaki;Masanori Asakura;Seiji Takashima

  • Heparin-binding EGF-like growth factor accelerates keratinocyte migration and skin wound healing

    Yuji Shirakata;Rina Kimura;Daisuke Nanba;Ryo Iwamoto

  • The Integrin α9β1 Binds to a Novel Recognition Sequence (SVVYGLR) in the Thrombin-cleaved Amino-terminal Fragment of Osteopontin

    Yasuyuki Yokosaki;Nariaki Matsuura;Tomohiro Sasaki;Isao Murakami

  • Expression and clinical significance of erb-B receptor family in hepatocellular carcinoma.

    Y Ito;T Takeda;M Sakon;M Tsujimoto

  • Heparin-binding EGF-like growth factor, which acts as the diphtheria toxin receptor, forms a complex with membrane protein DRAP27/CD9, which up-regulates functional receptors and diphtheria toxin sensitivity

    R. Iwamoto;S. Higashiyama;T. Mitamura;N. Taniguchi

  • Ectodomain Shedding of Epidermal Growth Factor Receptor Ligands Is Required for Keratinocyte Migration in Cutaneous Wound Healing

    Sho Tokumaru;Sho Tokumaru;Shigeki Higashiyama;Takeshi Endo;Takatoshi Nakagawa

  • The membrane protein CD9/DRAP 27 potentiates the juxtacrine growth factor activity of the membrane-anchored heparin-binding EGF-like growth factor.

    S Higashiyama;R Iwamoto;K Goishi;G Raab

  • Phorbol ester induces the rapid processing of cell surface heparin-binding EGF-like growth factor: conversion from juxtacrine to paracrine growth factor activity.

    K Goishi;S Higashiyama;M Klagsbrun;N Nakano

  • Membrane-anchored growth factors, the epidermal growth factor family : Beyond receptor ligands

    Shigeki Higashiyama;Hidehiko Iwabuki;Chie Morimoto;Miki Hieda

  • Isolation and characterization of a macrophage-derived heparin-binding growth factor.

    G Besner;S Higashiyama;M Klagsbrun

  • HB-EGF is a potent inducer of tumor growth and angiogenesis.

    Pat P. Ongusaha;Jennifer C. Kwak;Andrew J. Zwible;Salvador Macip

Frequent Co-Authors

Naoyuki Taniguchi
Naoyuki Taniguchi Osaka University
Yuji Matsuzawa
Yuji Matsuzawa Sumitomo Hospital
Koji Hashimoto
Koji Hashimoto Ehime University
Eisuke Mekada
Eisuke Mekada Osaka University
Yasuhisa Shinomura
Yasuhisa Shinomura Sapporo Medical University
Yann Barrandon
Yann Barrandon École Polytechnique Fédérale de Lausanne
Michael Klagsbrun
Michael Klagsbrun Boston Children's Hospital
Masatsugu Hori
Masatsugu Hori Osaka University
Nobuyuki Takei
Nobuyuki Takei Niigata University
Hiroyuki Nawa
Hiroyuki Nawa Wakayama Medical University

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