Dean Sheppard

Research.com Recognitions

• 2017 - Fellow of the American Academy of Arts and Sciences
• Member of the Association of American Physicians
• Member of the Association of American Physicians

Overview

Best Publications

• The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis.

  John S Munger;Xiaozhu Huang;Hisaaki Kawakatsu;Mark J.D Griffiths

  2956
  Citations

• Requirement for IL-13 independently of IL-4 in experimental asthma

  G. Grünig;M. Warnock;A. E. Wakil;R. Venkayya

  2872
  Citations

• Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix

  Kevin K. Kim;Matthias C. Kugler;Paul J. Wolters;Liliane Robillard

  1469
  Citations

• The importance of race and ethnic background in biomedical research and clinical practice.

  Esteban González Burchard;Elad Ziv;Natasha Coyle;Scarlett Lin Gomez

  1344
  Citations

• Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma

  Douglas A. Kuperman;Xiaozhu Huang;Laura L. Koth;Grace H. Chang

  1191
  Citations

• The integrin αvβ8 mediates epithelial homeostasis through MT1-MMP–dependent activation of TGF-β1

  Dezhi Mu;Stephanie Cambier;Stephanie Cambier;Lars Fjellbirkeland;Lars Fjellbirkeland;Jody L. Baron

  1034
  Citations

• Enhanced Pathological Angiogenesis in Mice Lacking beta3 Integrin or beta3 and beta5 Integrins

  Louise E. Reynolds;Lorenza Wyder;Julie C. Lively;Daniela Taverna

  908
  Citations

• Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs

  Neil C Henderson;Thomas D Arnold;Yoshio Katamura;Marilyn M Giacomini

  867
  Citations

• TGF-β Activation and Function in Immunity

  Mark A Travis;Dean Sheppard

  846
  Citations

• Therapy for Fibrotic Diseases: Nearing the Starting Line

  Scott L. Friedman;Dean Sheppard;Jeremy S. Duffield;Shelia Violette

  832
  Citations

• Gene expression analysis reveals matrilysin as a key regulator of pulmonary fibrosis in mice and humans

  Fengrong Zuo;Naftali Kaminski;Elsie Eugui;John Allard

  720
  Citations

• Loss of integrin alpha(v)beta6-mediated TGF-beta activation causes Mmp12-dependent emphysema.

  David G. Morris;Xiaozhu Huang;Naftali Kaminski;Yanli Wang

  678
  Citations

• Loss of integrin αvβ8 on dendritic cells causes autoimmunity and colitis in mice

  Mark A. Travis;Boris Reizis;Andrew C. Melton;Emma Masteller

  603
  Citations

• TGF-β is a critical mediator of acute lung injury

  Jean-Francois Pittet;Mark J.D. Griffiths;Tom Geiser;Naftali Kaminski

  602
  Citations

• TGF-β1 Signaling and Tissue Fibrosis.

  Kevin K. Kim;Dean Sheppard;Harold A. Chapman

  594
  Citations

• IL-17A produced by αβ T cells drives airway hyper-responsiveness in mice and enhances mouse and human airway smooth muscle contraction.

  Makoto Kudo;Andrew C Melton;Chun Chen;Mary B Engler

  526
  Citations

• Global analysis of gene expression in pulmonary fibrosis reveals distinct programs regulating lung inflammation and fibrosis

  Naftali Kaminski;John D. Allard;Jean F. Pittet;Fengrong Zuo

  506
  Citations

• Collagen-producing lung cell atlas identifies multiple subsets with distinct localization and relevance to fibrosis.

  Tatsuya Tsukui;Kai-Hui Sun;Joseph B Wetter;John R Wilson-Kanamori

  457
  Citations

• Partial Inhibition of Integrin αvβ6 Prevents Pulmonary Fibrosis without Exacerbating Inflammation

  Gerald S. Horan;Susan Wood;Victor Ona;Dan Jun Li

  453
  Citations

• Transcriptional activation of integrin β6 during the epithelial-mesenchymal transition defines a novel prognostic indicator of aggressive colon carcinoma

  Richard C. Bates;David I. Bellovin;Courtney Brown;Elizabeth Maynard

  449
  Citations