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Biology and Biochemistry

D-Index
79
Citations
19993
World Ranking
4372
National Ranking
283

Overview

Toshiaki Isobe is affiliated with Tokyo Metropolitan University in Japan. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, and Medicine, with a significant focus on molecular biology and related subfields.

The scientist's recent publications cover a range of topics pertinent to RNA modifications, protein synthesis mechanisms, and parasitic infections. Notable papers include:

  • Dynamic RNA acetylation revealed by quantitative cross-evolutionary mapping (2020), published in Nature
  • DKC1 Overexpression Induces a More Aggressive Cellular Behavior and Increases Intrinsic Ribosomal Activity in Immortalized Mammary Gland Cells (2020), published in Cancers
  • Cryo-EM structure of the highly atypical cytoplasmic ribosome of Euglena gracilis (2020), published in Nucleic Acids Research
  • Direct Determination of Pseudouridine in RNA by Mass Spectrometry Coupled with Stable Isotope Labeling (2020), published in Analytical Chemistry
  • A single pseudouridine on rRNA regulates ribosome structure and function in the mammalian parasite Trypanosoma brucei (2023), published in Nature Communications

The main topics covered in their work include:

  • RNA modifications and cancer
  • RNA and protein synthesis mechanisms
  • Immune response and inflammation
  • RNA research and splicing
  • Neonatal health and biochemistry
  • Trypanosoma species research and implications
  • Parasitic infections and diagnostics

Frequent coauthors collaborating with Toshiaki Isobe are:

  • Masato Taoka
  • Yuko Nobe
  • Yoshio Yamauchi
  • Anat Bashan
  • Ada Yonath

The scientist has published multiple works in leading venues, including:

  • Nucleic Acids Research
  • The Journal of Experimental Medicine
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature
  • Nature Communications

Within their subfields of study, Toshiaki Isobe's research includes molecular biology, immunology, epidemiology, surgery, and physiology. This multidisciplinary approach contributes to understanding complex biological processes related to RNA and protein function, immune responses, and parasitic diseases.

Best Publications

  • Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages

    Kohichi Matsunaga;Tatsuya Saitoh;Keisuke Tabata;Hiroko Omori

  • Lectin affinity capture, isotope-coded tagging and mass spectrometry to identify N-linked glycoproteins

    Hiroyuki Kaji;Haruna Saito;Yoshio Yamauchi;Takashi Shinkawa

  • Molecular cloning of cDNA coding for brain-specific 14-3-3 protein, a protein kinase-dependent activator of tyrosine and tryptophan hydroxylases

    Tohru Ichimura;Toshiaki Isobe;Tsuneo Okuyama;Nobuhiro Takahashi

  • The amino-acid sequence of S-100 protein (PAP I-b protein) and its relation to the calcium-binding proteins.

    Toshiaki Isobe;Tsuneo Okuyama

  • Structural Analysis Reveals that Toll-like Receptor 7 Is a Dual Receptor for Guanosine and Single-Stranded RNA.

    Zhikuan Zhang;Umeharu Ohto;Takuma Shibata;Elena Krayukhina

  • Immunohistochemical study on the distribution of α and β subunits of S-100 protein in human neoplasm and normal tissues

    Kiyoshi Takahashi;Toshiaki Isobe;Yuji Ohtsuki;Tadaatsu Akagi

  • Brain 14-3-3 protein is an activator protein that activates tryptophan 5-monooxygenase and tyrosine 3-monooxygenase in the presence of Ca2+,calmodulin-dependent protein kinase II

    Tohru Ichimura;Toshiaki Isobe;Tsueno Okuyama;Takashi Yamauchi

  • Epiregulin: A NOVEL EPIDERMAL GROWTH FACTOR WITH MITOGENIC ACTIVITY FOR RAT PRIMARY HEPATOCYTES ∗

    Hitoshi Toyoda;Toshi Komurasaki;Daisuke Uchida;Yasuko Takayama

  • Toll-like receptor 8 senses degradation products of single-stranded RNA.

    Hiromi Tanji;Umeharu Ohto;Takuma Shibata;Masato Taoka

  • The Amino-Acid Sequence of the α Subunit in Bovine Brain S-100a Protein

    Toshiaki Isobe;Tsuneo Okuyama

  • Phosphorylation of αB-Crystallin in Response to Various Types of Stress

    Hidenori Ito;Keiko Okamoto;Hiroshi Nakayama;Toshiaki Isobe

  • Landscape of the complete RNA chemical modifications in the human 80S ribosome

    Masato Taoka;Yuko Nobe;Yuka Yamaki;Ko Sato

  • Reinvestigation of extremely acidic proteins in bovine brain

    Toshiaki Isobe;Toshiaki Nakajima;Tsuneo Okuyama

  • The cerebellar leucine-rich acidic nuclear protein interacts with ataxin-1

    Antoni Matilla;Beena T. Koshy;Christopher J. Cummings;Toshiaki Isobe

  • Molecular constituents of the postsynaptic density fraction revealed by proteomic analysis using multidimensional liquid chromatography-tandem mass spectrometry.

    Yoshiyuki Yoshimura;Yoshio Yamauchi;Takashi Shinkawa;Masato Taoka

  • 14-3-3 Proteins Modulate the Expression of Epithelial Na+ Channels by Phosphorylation-dependent Interaction with Nedd4-2 Ubiquitin Ligase

    Tohru Ichimura;Hisao Yamamura;Kaname Sasamoto;Yuri Tominaga

  • Dynamic RNA acetylation revealed by quantitative cross-evolutionary mapping

    Aldema Sas-Chen;Justin M. Thomas;Donna Matzov;Masato Taoka

  • A direct nanoflow liquid chromatography-tandem mass spectrometry system for interaction proteomics.

    Tohru Natsume;Yoshio Yamauchi;Hiroshi Nakayama;Takashi Shinkawa

  • Structural Relation of Two S‐100 Proteins in Bovine Brain; Subunit Composition of S‐100 a Protein

    Toshiaki Isobe;Noriaki Ishioka;Tsuneo Okuyama

  • S100a0 (αα) Protein Is Present in Neurons of the Central and Peripheral Nervous System

    Toshiaki Isobe;Kiyoshi Takahashi;Tsuneo Okuyama

Frequent Co-Authors

Nobuhiro Takahashi
Nobuhiro Takahashi Tokyo University of Agriculture and Technology
Yasuo Takahashi
Yasuo Takahashi Niigata University
Ryozo Kuwano
Ryozo Kuwano Niigata University
Richard J. Simpson
Richard J. Simpson La Trobe University
Tohru Natsume
Tohru Natsume National Institute of Advanced Industrial Science and Technology
Shin-ichi Hisanaga
Shin-ichi Hisanaga Tokyo Metropolitan University
Hisatake Kondo
Hisatake Kondo Tohoku University
Jinrong Min
Jinrong Min Structural Genomics Consortium
Kensuke Miyake
Kensuke Miyake Tokyo University of Science
Naohiko Koshikawa
Naohiko Koshikawa Tokyo Institute of Technology

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