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Biology and Biochemistry

D-Index
71
Citations
14197
World Ranking
6802
National Ranking
457

Overview

Shin-ichi Hisanaga is a researcher affiliated with Tokyo Metropolitan University in Japan. Their work spans several interconnected fields, primarily within biochemistry, genetics, molecular biology, and medicine. Their research contributions cover key subfields such as molecular biology, cell biology, neurology, physiology, and oncology.

The scientist's research focuses on significant topics including Alzheimer's disease research and treatments, microtubule and mitosis dynamics, cellular transport and secretion, Parkinson's disease mechanisms and treatments, cancer-related molecular pathways, neuroscience and neuropharmacology research, and neurological diseases and metabolism.

Recent representative publications by the researcher include:

  • "α-synuclein strains that cause distinct pathologies differentially inhibit proteasome," 2020, eLife
  • "Distinct phosphorylation profiles of tau in brains of patients with different tauopathies," 2021, Neurobiology of Aging
  • "Map7D2 and Map7D1 facilitate microtubule stabilization through distinct mechanisms in neuronal cells," 2022, Life Science Alliance
  • "In vivo analysis of the phosphorylation of tau and the tau protein kinases Cdk5-p35 and GSK3β by using Phos-tag SDS-PAGE," 2022, Journal of Proteomics
  • "Valproic Acid-Induced Anxiety and Depression Behaviors are Ameliorated in p39 Cdk5 Activator-Deficient Mice," 2022, Neurochemical Research

Frequent coauthors collaborating with Hisanaga include Kanae Ando, Masato Hasegawa, Taro Saito, Ran Wei, and Taeko Kimura. These collaborations have supported work across various topics and research papers.

Publications by Shin-ichi Hisanaga frequently appear in several scientific journals and venues, with multiple contributions to Neurochemical Research, The Journal of Biochemistry, bioRxiv (Cold Spring Harbor Laboratory), eLife, and Neurobiology of Aging.

Best Publications

  • Inhibition of Heparin-induced Tau Filament Formation by Phenothiazines, Polyphenols, and Porphyrins

    Sayuri Taniguchi;Nobuyuki Suzuki;Masami Masuda;Shin-ichi Hisanaga

  • Small Molecule Inhibitors of α-Synuclein Filament Assembly†

    Masami Masuda;Nobuyuki Suzuki;Sayuri Taniguchi;Takayuki Oikawa

  • Calpain-dependent proteolytic cleavage of the p35 cyclin-dependent kinase 5 activator to p25.

    Gen-ichi Kusakawa;Gen-ichi Kusakawa;Taro Saito;Reiko Onuki;Reiko Onuki;Koichi Ishiguro

  • Cyclin B interaction with microtubule-associated protein 4 (MAP4) targets p34cdc2 kinase to microtubules and is a potential regulator of M-phase microtubule dynamics.

    K. Ookata;S.-I. Hisanaga;J. C. Bulinski;H. Murofushi

  • Structure of the peripheral domains of neurofilaments revealed by low angle rotary shadowing.

    Shin-ichi Hisanaga;Nobutaka Hirokawa

  • Relocation and distinct subcellular localization of p34cdc2-cyclin B complex at meiosis reinitiation in starfish oocytes.

    K. Ookata;S.-I. Hisanaga;T. Okano;K. Tachibana

  • Tubulin Seeds α-Synuclein Fibril Formation

    Muhammad Abdul Alim;Mosammat Shahanara Hossain;Kunimasa Arima;Kazuya Takeda

  • Physiological and pathological phosphorylation of tau by Cdk5

    Taeko Kimura;Koichi Ishiguro;Shin-ichi Hisanaga

  • Demonstration of a role for α-synuclein as a functional microtubule-associated protein

    Muhammad Abdul Alim;Qiu-Lan Ma;Kazuya Takeda;Takako Aizawa

  • MAP2 is a component of crossbridges between microtubules and neurofilaments in the neuronal cytoskeleton: quick-freeze, deep-etch immunoelectron microscopy and reconstitution studies

    N Hirokawa;S Hisanaga;Y Shiomura

  • Abnormal phosphorylation of Ser409/410 of TDP-43 in FTLD-U and ALS

    Yuki Inukai;Takashi Nonaka;Tetsuaki Arai;Mari Yoshida

  • Cophosphorylation of amphiphysin I and dynamin I by Cdk5 regulates clathrin-mediated endocytosis of synaptic vesicles.

    Kazuhito Tomizawa;Satoshi Sunada;Yun Fei Lu;Yoshiya Oda

  • Propagation of pathological α-synuclein in marmoset brain.

    Aki Shimozawa;Aki Shimozawa;Maiko Ono;Maiko Ono;Daisuke Takahara;Airi Tarutani;Airi Tarutani

  • Regulation of Mitochondrial Transport and Inter-Microtubule Spacing by Tau Phosphorylation at the Sites Hyperphosphorylated in Alzheimer's Disease

    Kourosh Shahpasand;Isao Uemura;Taro Saito;Tsunaki Asano

  • Phosphorylation of neurofilament H subunit at the tail domain by CDC2 kinase dissociates the association to microtubules.

    S.-I. Hisanaga;M. Kusubata;E. Okumura;T. Kishimoto

  • Truncation of CDK5 activator p35 induces intensive phosphorylation of Ser202/Thr205 of human tau

    Mitsuko Hashiguchi;Taro Saito;Shin-ichi Hisanaga;Toshio Hashiguchi

  • Distinct migratory behavior of early- and late-born neurons derived from the cortical ventricular zone.

    Yumiko Hatanaka;Shin-Ichi Hisanaga;Claus W. Heizmann;Fujio Murakami;Fujio Murakami

  • Calpain‐mediated degradation of p35 to p25 in postmortem human and rat brains

    S. Taniguchi;Y. Fujita;S. Hayashi;A. Kakita

  • Regulation and role of cyclin-dependent kinase activity in neuronal survival and death

    Shin-ichi Hisanaga;Ryo Endo

  • Conversion of Wild-type α-Synuclein into Mutant-type Fibrils and Its Propagation in the Presence of A30P Mutant

    Motokuni Yonetani;Takashi Nonaka;Masami Masuda;Yuki Inukai

Frequent Co-Authors

Masato Hasegawa
Masato Hasegawa Tokyo Metropolitan Institute of Medical Science
Takeo Kishimoto
Takeo Kishimoto Tokyo Institute of Technology
Koichi Ishiguro
Koichi Ishiguro Juntendo University
Nobutaka Hirokawa
Nobutaka Hirokawa University of Tokyo
Takashi Nonaka
Takashi Nonaka Tokyo Metropolitan Institute of Medical Science
Toshio Ohshima
Toshio Ohshima Waseda University
Mitsunori Fukuda
Mitsunori Fukuda Tohoku University
Hikoichi Sakai
Hikoichi Sakai University of Tokyo
Toshiaki Isobe
Toshiaki Isobe Tokyo Metropolitan University
Takeshi Iwatsubo
Takeshi Iwatsubo University of Tokyo

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