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Koichi Ishiguro

Koichi Ishiguro

Juntendo University
Japan

D-Index & Metrics

Biology and Biochemistry

D-Index
64
Citations
13211
World Ranking
9774
National Ranking
655

Koichi Ishiguro publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where Koichi Ishiguro sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 413 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 848 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 949 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 840 scientists 207–216 publications: 733 scientists 217–226 publications: 708 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 417 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 196 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 59 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 139 publications — 21st percentile

21% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

Koichi Ishiguro D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Koichi Ishiguro sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 316 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 899 scientists 52–53 D-Index: 1,025 scientists 54–55 D-Index: 1,149 scientists 56–57 D-Index: 1,235 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,162 scientists 62–63 D-Index: 1,130 scientists 64–65 D-Index: 1,031 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 714 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 71 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 64 D-Index — 52nd percentile

52% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Overview

Koichi Ishiguro is affiliated with Juntendo University in Japan with a research focus primarily in medicine. Their work spans various subfields including physiology, cellular and molecular neuroscience, pharmacology, psychiatry and mental health, and neurology.

Their research largely concentrates on Alzheimer's disease and related neurodegenerative disorders, covering topics such as Alzheimer's disease research and treatments, cholinesterase and neurodegenerative diseases, dementia and cognitive impairment research, neuroscience and neuropharmacology research, drug transport and resistance mechanisms, autophagy in disease and therapy, and Parkinson's disease mechanisms and treatments.

Selected recent papers authored by Ishiguro include:

  • High-fat diet-induced activation of SGK1 promotes Alzheimer's disease-associated tau pathology, 2021, Human Molecular Genetics
  • Asparagine residue 368 is involved in Alzheimer's disease tau strain-specific aggregation, 2020, Journal of Biological Chemistry
  • Strain-specific clearance of seed-dependent tau aggregation by lithium-induced autophagy, 2021, Biochemical and Biophysical Research Communications
  • Learning Deficits Accompanied by Microglial Proliferation After the Long-Term Post-Injection of Alzheimer's Disease Brain Extract in Mouse Brains, 2021, Journal of Alzheimer s Disease
  • High-fat diet-induced activation of SGK1 promotes Alzheimer's disease-associated tau pathology, 2020, bioRxiv (Cold Spring Harbor Laboratory)

Frequent co-authors in Ishiguro's research include:

  • Montasir Elahi
  • Yumiko Motoi
  • Shotaro Shimonaka
  • Nobutaka Hattori
  • Masashi Takanashi

Ishiguro has published repeatedly in venues such as Alzheimer s & Dementia, Human Molecular Genetics, Journal of Biological Chemistry, Biochemical and Biophysical Research Communications, and Journal of Alzheimer s Disease.

Best Publications

  • Measurement of phosphorylated tau epitopes in the differential diagnosis of Alzheimer disease: a comparative cerebrospinal fluid study.

    Harald Hampel;Katharina Buerger;Raymond Zinkowski;Stefan J. Teipel

  • Glycogen synthase kinase 3β is identical to tau protein kinase I generating several epitopes of paired helical filaments

    Koichi Ishiguro;Akiko Shiratsuchi;Showbu Sato;Akira Omori

  • Calpain-dependent proteolytic cleavage of the p35 cyclin-dependent kinase 5 activator to p25.

    Gen-ichi Kusakawa;Gen-ichi Kusakawa;Taro Saito;Reiko Onuki;Reiko Onuki;Koichi Ishiguro

  • Activation of tau protein kinase I/glycogen synthase kinase-3β by amyloid β peptide (25–35) enhances phosphorylation of tau in hippocampal neurons

    Akihiko Takashima;Toshiyuki Honda;Kaori Yasutake;Gilles Michel

  • Regulation of mitochondrial pyruvate dehydrogenase activity by tau protein kinase I/glycogen synthase kinase 3beta in brain

    Minako Hoshi;Akihiko Takashima;Kaori Noguchi;Miyuki Murayama

  • Exposure of rat hippocampal neurons to amyloid β peptide (25–35) induces the inactivation of phosphatidyl inositol-3 kinase and the activation of tau protein kinase I/glycogen synthase kinase-3β

    Akihiko Takashima;Kaori Noguchi;Gilles Michel;Marc Mercken

  • Tau protein kinase I converts normal tau protein into A68-like component of paired helical filaments.

    K Ishiguro;M Takamatsu;K Tomizawa;A Omori

  • Preferential labeling of Alzheimer neurofibrillary tangles with antisera for tau protein kinase (TPK) I/glycogen synthase kinase-3 beta and cyclin-dependent kinase 5, a component of TPK II

    Haruyasu Yamaguchi;Koichi Ishiguro;Tsuneko Uchida;Akihiko Takashima

  • Tau filament formation and associative memory deficit in aged mice expressing mutant (R406W) human tau

    Yoshitaka Tatebayashi;Tomohiro Miyasaka;De-Hua Chui;Takumi Akagi

  • Alterations in Glucose Metabolism Induce Hypothermia Leading to Tau Hyperphosphorylation through Differential Inhibition of Kinase and Phosphatase Activities: Implications for Alzheimer's Disease

    Emmanuel Planel;Tomohiro Miyasaka;Thomas Launey;De Hua Chui

  • Site-specific Phosphorylation of Synapsin I by Mitogen-activated Protein Kinase and Cdk5 and Its Effects on Physiological Functions

    Mamoru Matsubara;Masashi Kusubata;Koichi Ishiguro;Tsuneko Uchida

  • A cdc2-related kinase PSSALRE/cdk5 is homologous with the 30 kDa subunit of tau protein kinase II, a proline-directed protein kinase associated with microtubule

    Shunsuke Kobayashi;Koichi Ishiguro;Akira Omori;Masako Takamatsu

  • Large-scale, multicenter study of cerebrospinal fluid tau protein phosphorylated at serine 199 for the antemortem diagnosis of Alzheimer's disease

    Nobuo Itoh;Hiroyuki Arai;Katsuya Urakami;Koichi Ishiguro

  • Inhibition of Protein Phosphatase 2A Overrides Tau Protein Kinase I/Glycogen Synthase Kinase 3β and Cyclin-dependent Kinase 5 Inhibition and Results in Tau Hyperphosphorylation in the Hippocampus of Starved Mouse

    Emmanuel Planel;Kaori Yasutake;Shinobu C. Fujita;Koichi Ishiguro

  • Physiological and pathological phosphorylation of tau by Cdk5

    Taeko Kimura;Koichi Ishiguro;Shin-ichi Hisanaga

  • Alternative splicing isoform of tau protein kinase I/glycogen synthase kinase 3beta.

    Fumiko Mukai;Koichi Ishiguro;Yumiko Sano;Shinobu C. Fujita

  • Phosphorylated tau in human cerebrospinal fluid is a diagnostic marker for Alzheimer's disease.

    Koichi Ishiguro;Hideto Ohno;Hiroyuki Arai;Haruyasu Yamaguchi

  • Phosphorylation sites on tau by tau protein kinase I, a bovine derived kinase generating an epitope of paired helical filaments.

    Koichi Ishiguro;Akira Omori;Masako Takamatsu;Kazuki Sato

  • Identification of amino‐terminally cleaved tau fragments that distinguish progressive supranuclear palsy from corticobasal degeneration

    Tetsuaki Arai;Kenji Ikeda;Haruhiko Akiyama;Takashi Nonaka

  • Nontoxic amyloid beta peptide 1-42 suppresses acetylcholine synthesis. Possible role in cholinergic dysfunction in Alzheimer's disease.

    Minako Hoshi;Akihiko Takashima;Miyuki Murayama;Kaori Yasutake

Frequent Co-Authors

Shin-ichi Hisanaga
Shin-ichi Hisanaga Tokyo Metropolitan University
Nobutaka Hattori
Nobutaka Hattori Juntendo University
Masato Hasegawa
Masato Hasegawa Tokyo Metropolitan Institute of Medical Science
Kazuki Sato
Kazuki Sato Fukuoka Women's University
Akihiko Takashima
Akihiko Takashima Gakushuin University
Mikio Shoji
Mikio Shoji Hirosaki University
Hiroyuki Arai
Hiroyuki Arai University of Tokyo
Takeo Kishimoto
Takeo Kishimoto Tokyo Institute of Technology
Katharina Buerger
Katharina Buerger Ludwig-Maximilians-Universität München
Masatoshi Takeda
Masatoshi Takeda Izumi University

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Best Scientists Citing Koichi Ishiguro

Kaj Blennow

Kaj Blennow

University of Gothenburg

Publications: 112

Jesús Avila

Jesús Avila

Centro de Biología Molecular Severo Ochoa

Publications: 102

Henrik Zetterberg

Henrik Zetterberg

University of Gothenburg

Publications: 76

Shin-ichi Hisanaga

Shin-ichi Hisanaga

Tokyo Metropolitan University

Publications: 63

Jian-Zhi Wang

Jian-Zhi Wang

Huazhong University of Science and Technology

Publications: 62

Li-Huei Tsai

Li-Huei Tsai

MIT

Publications: 60

Harald Hampel

Harald Hampel

Eisai (United States)

Publications: 58

Masato Hasegawa

Masato Hasegawa

Tokyo Metropolitan Institute of Medical Science

Publications: 53

Harish C. Pant

Harish C. Pant

National Institutes of Health

Publications: 49

Akihiko Takashima

Akihiko Takashima

Gakushuin University

Publications: 48

Luc Buée

Luc Buée

University of Lille

Publications: 47

John Q. Trojanowski

John Q. Trojanowski

University of Pennsylvania

Publications: 45

Inge Grundke-Iqbal

Inge Grundke-Iqbal

University of York

Publications: 42

Toshio Ohshima

Toshio Ohshima

Waseda University

Publications: 42

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Virginia M.-Y. Lee

University of Pennsylvania

Publications: 40

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Michel Goedert

MRC Laboratory of Molecular Biology

Publications: 35

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