Koichi Ishiguro

Overview

Best Publications

• Measurement of phosphorylated tau epitopes in the differential diagnosis of Alzheimer disease: a comparative cerebrospinal fluid study.

  Harald Hampel;Katharina Buerger;Raymond Zinkowski;Stefan J. Teipel

  592
  Citations

• Glycogen synthase kinase 3β is identical to tau protein kinase I generating several epitopes of paired helical filaments

  Koichi Ishiguro;Akiko Shiratsuchi;Showbu Sato;Akira Omori

  548
  Citations

• Calpain-dependent proteolytic cleavage of the p35 cyclin-dependent kinase 5 activator to p25.

  Gen-ichi Kusakawa;Gen-ichi Kusakawa;Taro Saito;Reiko Onuki;Reiko Onuki;Koichi Ishiguro

  488
  Citations

• Activation of tau protein kinase I/glycogen synthase kinase-3β by amyloid β peptide (25–35) enhances phosphorylation of tau in hippocampal neurons

  Akihiko Takashima;Toshiyuki Honda;Kaori Yasutake;Gilles Michel

  411
  Citations

• Regulation of mitochondrial pyruvate dehydrogenase activity by tau protein kinase I/glycogen synthase kinase 3beta in brain

  Minako Hoshi;Akihiko Takashima;Kaori Noguchi;Miyuki Murayama

  374
  Citations

• Exposure of rat hippocampal neurons to amyloid β peptide (25–35) induces the inactivation of phosphatidyl inositol-3 kinase and the activation of tau protein kinase I/glycogen synthase kinase-3β

  Akihiko Takashima;Kaori Noguchi;Gilles Michel;Marc Mercken

  365
  Citations

• Tau protein kinase I converts normal tau protein into A68-like component of paired helical filaments.

  K Ishiguro;M Takamatsu;K Tomizawa;A Omori

  359
  Citations

• Preferential labeling of Alzheimer neurofibrillary tangles with antisera for tau protein kinase (TPK) I/glycogen synthase kinase-3 beta and cyclin-dependent kinase 5, a component of TPK II

  Haruyasu Yamaguchi;Koichi Ishiguro;Tsuneko Uchida;Akihiko Takashima

  353
  Citations

• Tau filament formation and associative memory deficit in aged mice expressing mutant (R406W) human tau

  Yoshitaka Tatebayashi;Tomohiro Miyasaka;De-Hua Chui;Takumi Akagi

  352
  Citations

• Alterations in Glucose Metabolism Induce Hypothermia Leading to Tau Hyperphosphorylation through Differential Inhibition of Kinase and Phosphatase Activities: Implications for Alzheimer's Disease

  Emmanuel Planel;Tomohiro Miyasaka;Thomas Launey;De Hua Chui

  351
  Citations

• Site-specific Phosphorylation of Synapsin I by Mitogen-activated Protein Kinase and Cdk5 and Its Effects on Physiological Functions

  Mamoru Matsubara;Masashi Kusubata;Koichi Ishiguro;Tsuneko Uchida

  339
  Citations

• A cdc2-related kinase PSSALRE/cdk5 is homologous with the 30 kDa subunit of tau protein kinase II, a proline-directed protein kinase associated with microtubule

  Shunsuke Kobayashi;Koichi Ishiguro;Akira Omori;Masako Takamatsu

  335
  Citations

• Large-scale, multicenter study of cerebrospinal fluid tau protein phosphorylated at serine 199 for the antemortem diagnosis of Alzheimer's disease

  Nobuo Itoh;Hiroyuki Arai;Katsuya Urakami;Koichi Ishiguro

  331
  Citations

• Inhibition of Protein Phosphatase 2A Overrides Tau Protein Kinase I/Glycogen Synthase Kinase 3β and Cyclin-dependent Kinase 5 Inhibition and Results in Tau Hyperphosphorylation in the Hippocampus of Starved Mouse

  Emmanuel Planel;Kaori Yasutake;Shinobu C. Fujita;Koichi Ishiguro

  288
  Citations

• Physiological and pathological phosphorylation of tau by Cdk5

  Taeko Kimura;Koichi Ishiguro;Shin-ichi Hisanaga

  273
  Citations

• Alternative splicing isoform of tau protein kinase I/glycogen synthase kinase 3beta.

  Fumiko Mukai;Koichi Ishiguro;Yumiko Sano;Shinobu C. Fujita

  254
  Citations

• Phosphorylated tau in human cerebrospinal fluid is a diagnostic marker for Alzheimer's disease.

  Koichi Ishiguro;Hideto Ohno;Hiroyuki Arai;Haruyasu Yamaguchi

  249
  Citations

• Phosphorylation sites on tau by tau protein kinase I, a bovine derived kinase generating an epitope of paired helical filaments.

  Koichi Ishiguro;Akira Omori;Masako Takamatsu;Kazuki Sato

  225
  Citations

• Identification of amino‐terminally cleaved tau fragments that distinguish progressive supranuclear palsy from corticobasal degeneration

  Tetsuaki Arai;Kenji Ikeda;Haruhiko Akiyama;Takashi Nonaka

  222
  Citations

• Nontoxic amyloid beta peptide 1-42 suppresses acetylcholine synthesis. Possible role in cholinergic dysfunction in Alzheimer's disease.

  Minako Hoshi;Akihiko Takashima;Miyuki Murayama;Kaori Yasutake

  213
  Citations