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Akihiko Takashima

Akihiko Takashima

D-Index & Metrics

Biology and Biochemistry

D-Index
77
Citations
20226
World Ranking
4805
National Ranking
313

Overview

Akihiko Takashima is affiliated with Gakushuin University in Japan and conducts research primarily in the fields of Medicine and Neuroscience. Their work covers multiple subfields including Physiology, Cellular and Molecular Neuroscience, Molecular Biology, Neurology, and Cognitive Neuroscience.

The scientist's research focuses on topics related to Alzheimer's disease research and treatments, dementia and cognitive impairment research, memory and neural mechanisms, neuroscience and neuropharmacology research, neuroinflammation and neurodegeneration mechanisms, protein hydrolysis and bioactive peptides, and biochemical effects in animals.

Takashima's recent publications illustrate their contributions to neurodegenerative disease studies and molecular mechanisms associated with tau protein and cognitive decline. Notable papers include:

  • New Insights Into Drug Discovery Targeting Tau Protein, 2020, Frontiers in Molecular Neuroscience
  • Disulfide bond formation in microtubule-associated tau protein promotes tau accumulation and toxicity in vivo, 2021, Human Molecular Genetics
  • β-Lactolin, a Whey-Derived Lacto-Tetrapeptide, Prevents Alzheimer's Disease Pathologies and Cognitive Decline, 2020, Journal of Alzheimer s Disease
  • Amyloid β and tau pathology in brains of aged pinniped species (sea lion, seal, and walrus), 2021, Acta Neuropathologica Communications
  • Phosphorylation and oligomerization of α-synuclein associated with GSK-3β activation in the rTg4510 mouse model of tauopathy, 2020, Acta Neuropathologica Communications

Frequent co-authors who have collaborated extensively with Takashima include:

  • Yoshiyuki Soeda
  • Riki Koike
  • Yuta Takaichi
  • Hiroyuki Nakayama
  • Yasuhisa Ano

The researcher's work has been published multiple times in venues such as bioRxiv (Cold Spring Harbor Laboratory), Acta Neuropathologica Communications, Journal of Alzheimer s Disease, Communications Biology, and Scientific Reports.

Best Publications

  • Imaging of Tau Pathology in a Tauopathy Mouse Model and in Alzheimer Patients Compared to Normal Controls

    Masahiro Maruyama;Hitoshi Shimada;Tetsuya Suhara;Hitoshi Shinotoh

  • Potent anti-amyloidogenic and fibril-destabilizing effects of polyphenols in vitro: implications for the prevention and therapeutics of Alzheimer's disease

    Kenjiro Ono;Yuji Yoshiike;Akihiko Takashima;Kazuhiro Hasegawa

  • Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response

    Taiichi Katayama;Kazunori Imaizumi;Naoya Sato;Ko Miyoshi

  • Tau protein kinase I is essential for amyloid beta-protein-induced neurotoxicity.

    Akihiko Takashima;Kaori Noguchi;Kazuki Sato;Toshimitsu Hoshino

  • A CBP Binding Transcriptional Repressor Produced by the PS1/ϵ-Cleavage of N-Cadherin Is Inhibited by PS1 FAD Mutations

    Philippe Marambaud;Paul H Wen;Anindita Dutt;Junichi Shioi

  • Chaperones increase association of tau protein with microtubules

    Fei Dou;William J. Netzer;Kentaro Tanemura;Feng Li

  • Presenilin 1 associates with glycogen synthase kinase-3β and its substrate tau

    Akihiko Takashima;Miyuki Murayama;Ohoshi Murayama;Toshiyuki Kohno

  • GSK-3 is essential in the pathogenesis of Alzheimer's disease.

    Akihiko Takashima

  • Activation of tau protein kinase I/glycogen synthase kinase-3β by amyloid β peptide (25–35) enhances phosphorylation of tau in hippocampal neurons

    Akihiko Takashima;Toshiyuki Honda;Kaori Yasutake;Gilles Michel

  • Regulation of mitochondrial pyruvate dehydrogenase activity by tau protein kinase I/glycogen synthase kinase 3beta in brain

    Minako Hoshi;Akihiko Takashima;Kaori Noguchi;Miyuki Murayama

  • Exposure of rat hippocampal neurons to amyloid β peptide (25–35) induces the inactivation of phosphatidyl inositol-3 kinase and the activation of tau protein kinase I/glycogen synthase kinase-3β

    Akihiko Takashima;Kaori Noguchi;Gilles Michel;Marc Mercken

  • Granular tau oligomers as intermediates of tau filaments.

    Sumihiro Maeda;Naruhiko Sahara;Yuko Saito;Miyuki Murayama

  • Preferential labeling of Alzheimer neurofibrillary tangles with antisera for tau protein kinase (TPK) I/glycogen synthase kinase-3 beta and cyclin-dependent kinase 5, a component of TPK II

    Haruyasu Yamaguchi;Koichi Ishiguro;Tsuneko Uchida;Akihiko Takashima

  • Tau filament formation and associative memory deficit in aged mice expressing mutant (R406W) human tau

    Yoshitaka Tatebayashi;Tomohiro Miyasaka;De-Hua Chui;Takumi Akagi

  • Alterations in Glucose Metabolism Induce Hypothermia Leading to Tau Hyperphosphorylation through Differential Inhibition of Kinase and Phosphatase Activities: Implications for Alzheimer's Disease

    Emmanuel Planel;Tomohiro Miyasaka;Thomas Launey;De Hua Chui

  • Microtubule-associated protein tau is essential for long-term depression in the hippocampus

    Tetsuya Kimura;Daniel J. Whitcomb;Jihoon Jo;Philip Regan

  • Increased levels of granular tau oligomers: an early sign of brain aging and Alzheimer's disease.

    Sumihiro Maeda;Naruhiko Sahara;Yuko Saito;Shigeo Murayama

  • Insulin Dysfunction Induces In Vivo Tau Hyperphosphorylation through Distinct Mechanisms

    Emmanuel Planel;Yoshitaka Tatebayashi;Tomohiro Miyasaka;Li Liu

  • New Insights on How Metals Disrupt Amyloid β-Aggregation and Their Effects on Amyloid-β Cytotoxicity *

    Yuji Yoshiike;Kentaro Tanemura;Ohoshi Murayama;Takumi Akagi

  • Neurodegeneration with Tau Accumulation in a Transgenic Mouse Expressing V337M Human Tau

    Kentaro Tanemura;Miyuki Murayama;Takumi Akagi;Tsutomu Hashikawa

Frequent Co-Authors

Koichi Ishiguro
Koichi Ishiguro Juntendo University
Tsutomu Hashikawa
Tsutomu Hashikawa RIKEN Center for Brain Science
Nuno Sousa
Nuno Sousa University of Minho
Yasuo Ihara
Yasuo Ihara Doshisha University
Masahito Yamada
Masahito Yamada Kanazawa University
Osborne F. X. Almeida
Osborne F. X. Almeida Max Planck Institute of Psychiatry
Takaomi C. Saido
Takaomi C. Saido RIKEN Center for Brain Science
Benjamin Wolozin
Benjamin Wolozin Boston University
Makoto Higuchi
Makoto Higuchi National Institutes for Quantum and Radiological Science and Technology
Hideyuki Okano
Hideyuki Okano Keio University

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