World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
60
Citations
11539
World Ranking
12064
National Ranking
5168

Overview

Mario Medvedovic is affiliated with the University of Cincinnati in the United States. Their research primarily spans the disciplines of biochemistry, genetics, molecular biology, and medicine. Within these broad fields, their work focuses on several subfields including molecular biology, immunology, cancer research, computational theory and mathematics, and epidemiology.

Their scholarly output includes numerous contributions to topics such as bioinformatics and genomic networks, gene regulatory network analysis, computational drug discovery methods, eosinophilic disorders and syndromes, advanced proteomics techniques and applications, epigenetics and DNA methylation, as well as extracellular vesicles in disease.

Among recent publications associated with Medvedovic, key papers include:

  • Connecting omics signatures and revealing biological mechanisms with iLINCS, 2022, Nature Communications
  • SigCom LINCS: data and metadata search engine for a million gene expression signatures, 2022, Nucleic Acids Research
  • Interferon-complement loop in transplant-associated thrombotic microangiopathy, 2020, Blood Advances
  • Metformin increases natural killer cell functions in head and neck squamous cell carcinoma through CXCL1 inhibition, 2022, Journal for ImmunoTherapy of Cancer
  • Mass spectrometry proteomics reveals a function for mammalian CALCOCO1 in MTOR-regulated selective autophagy, 2020, Autophagy

Frequent coauthors include:

  • Jacek Biesiada
  • Jarek Meller
  • David R. Plas
  • Behrouz Shamsaei
  • Nicholas A. Clark

Medvedovic's work has been published repeatedly in venues such as bioRxiv (Cold Spring Harbor Laboratory), Nucleic Acids Research, Medicine, PLoS ONE, and Clinical Cancer Research, indicating engagement with a range of biological and medical research journals.

Best Publications

  • The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations

    Alexandra B. Keenan;Sherry L. Jenkins;Kathleen M. Jagodnik;Simon Koplev

  • MicroRNA-494 Targeting Both Proapoptotic and Antiapoptotic Proteins Protects Against Ischemia/Reperfusion-Induced Cardiac Injury

    Xiaohong Wang;Xiaowei Zhang;Xiao-Ping Ren;Jing Chen

  • The N 6 -Methyladenosine mRNA Methylase METTL3 Controls Cardiac Homeostasis and Hypertrophy.

    Lisa E. Dorn;Lior Lasman;Jing Chen;Xianyao Xu

  • Clustering gene-expression data with repeated measurements.

    Ka Yee Yeung;Mario Medvedovic;Roger E Bumgarner

  • Intensity-based hierarchical Bayes method improves testing for differentially expressed genes in microarray experiments

    Maureen A Sartor;Craig R Tomlinson;Scott C Wesselkamper;Siva Sivaganesan

  • Bayesian mixture model based clustering of replicated microarray data

    M. Medvedovic;K.Y. Yeung;R.E. Bumgarner

  • The transcriptional signature of dioxin in human hepatoma HepG2 cells.

    Alvaro Puga;Andrew Maier;Mario Medvedovic

  • LRpath: a logistic regression approach for identifying enriched biological groups in gene expression data.

    Maureen A. Sartor;George D. Leikauf;Mario Medvedovic

  • Progression of BRAF -induced thyroid cancer is associated with epithelial–mesenchymal transition requiring concomitant MAP kinase and TGFβ signaling

    Jeffrey A Knauf;Maureen A Sartor;Maureen A Sartor;Mario Medvedovic;Emma Lundsmith

  • Control of Nutrient Stress-Induced Metabolic Reprogramming by PKCζ in Tumorigenesis

    Li Ma;Yongzhen Tao;Angeles Duran;Victoria Llado

  • Conditional activation of RET/PTC3 and BRAFV600E in thyroid cells is associated with gene expression profiles that predict a preferential role of BRAF in extracellular matrix remodeling.

    Cleo Mesa;Mana Mirza;Norisato Mitsutake;Maureen Sartor

  • The genetic fingerprint of susceptibility for transplant-associated thrombotic microangiopathy.

    Sonata Jodele;Kejian Zhang;Fanggeng Zou;Benjamin Laskin

  • Data Portal for the Library of Integrated Network-based Cellular Signatures (LINCS) program: integrated access to diverse large-scale cellular perturbation response data.

    Amar Koleti;Amar Koleti;Raymond Terryn;Raymond Terryn;Vasileios Stathias;Vasileios Stathias;Caty Chung;Caty Chung

  • Loss of the miR-144/451 cluster impairs ischaemic preconditioning-mediated cardioprotection by targeting Rac-1

    Xiaohong Wang;Hongyan Zhu;Xiaowei Zhang;Yong Liu

  • Loss of microRNA-128 promotes cardiomyocyte proliferation and heart regeneration.

    Wei Huang;Wei Huang;Yuliang Feng;Jialiang Liang;Hao Yu

  • From co-expression to co-regulation: how many microarray experiments do we need?

    Ka Yee Yeung;Mario Medvedovic;Roger E Bumgarner

  • LINCS Data Portal 2.0: next generation access point for perturbation-response signatures

    Vasileios Stathias;John Paul Turner;Amar Koleti;Dusica Vidovic

  • Expression of genes in the TGF-β signaling pathway is significantly deregulated in smooth muscle cells from aorta of aryl hydrocarbon receptor knockout mice

    Junhai Guo;Maureen Sartor;Saikumar Karyala;Mario Medvedovic

  • Genomewide analysis of aryl hydrocarbon receptor binding targets reveals an extensive array of gene clusters that control morphogenetic and developmental programs.

    Maureen A. Sartor;Michael Schnekenburger;Jennifer L. Marlowe;John F. Reichard

  • An Organoid-Based Preclinical Model of Human Gastric Cancer

    Nina G. Steele;Jayati Chakrabarti;Jiang Wang;Jacek Biesiada

Frequent Co-Authors

Maureen A. Sartor
Maureen A. Sartor University of Michigan–Ann Arbor
Shuk-Mei Ho
Shuk-Mei Ho University of Arkansas for Medical Sciences
George D. Leikauf
George D. Leikauf University of Pittsburgh
Alvaro Puga
Alvaro Puga University of Cincinnati Medical Center
Avi Ma'ayan
Avi Ma'ayan Icahn School of Medicine at Mount Sinai
Cheryl L. Walker
Cheryl L. Walker Baylor College of Medicine
Ying Xia
Ying Xia Fudan University
James A. Fagin
James A. Fagin Memorial Sloan Kettering Cancer Center
Yuri E. Nikiforov
Yuri E. Nikiforov University of Pittsburgh
Naftali Kaminski
Naftali Kaminski Yale University

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