World's Best Scientists 2026 revealed!

D-Index & Metrics

Medicine

D-Index
105
Citations
46634
World Ranking
6712
National Ranking
3543

Research.com Recognitions

  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

James A. Fagin is affiliated with the Memorial Sloan Kettering Cancer Center in the United States. Their research contributions span multiple fields including Medicine, Biochemistry, Genetics and Molecular Biology, with a strong focus on the subfields of Endocrinology, Diabetes and Metabolism, Molecular Biology, Oncology, Genetics, and Radiology, Nuclear Medicine and Imaging.

The scientist's work concentrates mainly on the diagnosis and treatment of thyroid cancer, a topic prominently reflected across many of their publications. Other significant research topics include cancer-related molecular pathways, BRCA gene mutations in cancer, ferroptosis and cancer prognosis, cancer genomics and diagnostics, genetic factors in colorectal cancer, and radiopharmaceutical chemistry and applications.

Recent key publications by James A. Fagin include:

  • Cancer therapy shapes the fitness landscape of clonal hematopoiesis (2020), Nature Genetics
  • Dissecting Anaplastic Thyroid Carcinoma: A Comprehensive Clinical, Histologic, Immunophenotypic, and Molecular Study of 360 Cases (2020), Thyroid
  • SWI/SNF Complex Mutations Promote Thyroid Tumor Progression and Insensitivity to Redifferentiation Therapies (2020), Cancer Discovery
  • The evolution of RET inhibitor resistance in RET-driven lung and thyroid cancers (2022), Nature Communications
  • American Head and Neck Society Endocrine Surgery Section and International Thyroid Oncology Group consensus statement on mutational testing in thyroid cancer: Defining advanced thyroid cancer and its targeted treatment (2022), Head & Neck

James A. Fagin has published extensively in several academic journals. The venues with the highest frequency of their publications include:

  • Thyroid
  • Journal of Clinical Oncology
  • Cancer Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancer Discovery

The scientist has collaborated frequently with a core group of co-authors, including:

  • Ronald Ghossein
  • Eric J. Sherman
  • Alan L. Ho
  • Gnana P. Krishnamoorthy
  • Jeffrey A. Knauf

Among their recognitions, James A. Fagin is a member of the Association of American Physicians. Their scholarly output and collaborative efforts contribute to multiple aspects of cancer biology, with a clear emphasis on molecular and clinical aspects of thyroid cancer and related malignancies.

Best Publications

  • Integrated Genomic Characterization of Papillary Thyroid Carcinoma

    Nishant Agrawal;Rehan Akbani;B. Arman Aksoy;Adrian Ally

  • High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma.

    Edna T. Kimura;Marina N. Nikiforova;Zhaowen Zhu;Jeffrey A. Knauf

  • Vandetanib in Patients With Locally Advanced or Metastatic Medullary Thyroid Cancer: A Randomized, Double-Blind Phase III Trial

    Samuel A. Wells;Bruce G. Robinson;Robert F. Gagel;Henning Dralle

  • BRAF Mutations in Thyroid Tumors Are Restricted to Papillary Carcinomas and Anaplastic or Poorly Differentiated Carcinomas Arising from Papillary Carcinomas

    Marina N. Nikiforova;Edna Teruko Kimura;Manoj Gandhi;Paul W. Biddinger

  • Genomic and transcriptomic hallmarks of poorly differentiated and anaplastic thyroid cancers

    Iñigo Landa;Tihana Ibrahimpasic;Laura Boucai;Rileen Sinha

  • Association between BRAF V600E mutation and mortality in patients with papillary thyroid cancer

    Michael Mingzhao Xing;Ali S. Alzahrani;Kathryn A. Carson;David Viola

  • Biologic and Clinical Perspectives on Thyroid Cancer

    James A. Fagin;Samuel A. Wells

  • Selumetinib-Enhanced Radioiodine Uptake in Advanced Thyroid Cancer

    Alan L. Ho;Ravinder K. Grewal;Rebecca Leboeuf;Eric J. Sherman

  • Molecular Testing for Mutations in Improving the Fine-Needle Aspiration Diagnosis of Thyroid Nodules

    Yuri E. Nikiforov;David L. Steward;Toni M. Robinson-Smith;Bryan R. Haugen

  • High prevalence of mutations of the p53 gene in poorly differentiated human thyroid carcinomas.

    J. A. Fagin;K. Matsuo;A. Karmakar;Dan Lin Chen

  • Distinct pattern of ret oncogene rearrangements in morphological variants of radiation-induced and sporadic thyroid papillary carcinomas in children.

    Yuri E. Nikiforov;Jon M. Rowland;Kevin E. Bove;Hector Monforte-Munoz

  • A paradigm for restenosis based on cell biology: clues for the development of new preventive therapies.

    James S. Forrester;Michael Fishbein;Richard Helfant;James Fagin

  • Estimating risk of recurrence in differentiated thyroid cancer after total thyroidectomy and radioactive iodine remnant ablation: using response to therapy variables to modify the initial risk estimates predicted by the new American Thyroid Association staging system.

    R. Michael Tuttle;Hernan Tala;Jatin Shah;Rebecca Leboeuf

  • Clonal Origin of Pituitary Adenomas

    Vivien Herman;James Fagin;Rivkah Gonsky;Kalman Kovacs

  • Mutational Profile Of Advanced Primary and Metastatic Radioactive Iodine-Refractory Thyroid Cancers Reveals Distinct Pathogenetic Roles for BRAF, PIK3CA and AKT1

    Julio C. Ricarte-Filho;Mabel Ryder;Dhananjay A. Chitale;Michael Rivera

  • Deoxyribonucleic acid profiling analysis of 40 human thyroid cancer cell lines reveals cross-contamination resulting in cell line redundancy and misidentification.

    Rebecca E. Schweppe;Joshua P. Klopper;Christopher Korch;Umarani Pugazhenthi

  • Relief of Profound Feedback Inhibition of Mitogenic Signaling by RAF Inhibitors Attenuates Their Activity in BRAFV600E Melanomas

    Piro Lito;Christine A. Pratilas;Eric W. Joseph;Madhavi Tadi

  • Association Between BRAF V600E Mutation and Recurrence of Papillary Thyroid Cancer

    Mingzhao Xing;Ali S. Alzahrani;Kathryn A. Carson;Young Kee Shong

  • Oncogenic AKAP9-BRAF fusion is a novel mechanism of MAPK pathway activation in thyroid cancer.

    Raffaele Ciampi;Jeffrey A. Knauf;Roswitha Kerler;Manoj Gandhi

  • AssociationBetween BRAFV600EMutationand MortalityinPatientsWithPapillaryThyroidCancer

    Mingzhao Xing;Ali S. Alzahrani;Kathryn A. Carson;David Viola

Frequent Co-Authors

Ronald Ghossein
Ronald Ghossein Memorial Sloan Kettering Cancer Center
Yuri E. Nikiforov
Yuri E. Nikiforov University of Pittsburgh
R. Michael Tuttle
R. Michael Tuttle Memorial Sloan Kettering Cancer Center
Shlomo Melmed
Shlomo Melmed Cedars-Sinai Medical Center
Ian Ganly
Ian Ganly Memorial Sloan Kettering Cancer Center
Michael F. Berger
Michael F. Berger Memorial Sloan Kettering Cancer Center
David G. Pfister
David G. Pfister Memorial Sloan Kettering Cancer Center
Marc Ladanyi
Marc Ladanyi Memorial Sloan Kettering Cancer Center
Ashok R. Shaha
Ashok R. Shaha Memorial Sloan Kettering Cancer Center
Thomas L. Clemens
Thomas L. Clemens United States Department of Veterans Affairs

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