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Biology and Biochemistry

D-Index
61
Citations
13431
World Ranking
11344
National Ranking
390

Overview

Jacquetta M. Trasler is affiliated with the McGill University Health Centre in Canada. Their research spans multiple fields with a strong focus on medicine and biochemistry, genetics, and molecular biology. The scientist's work extensively covers subfields such as molecular biology, pediatrics, perinatology and child health, rheumatology, public health, environmental and occupational health, and genetics.

Their research interests prominently include epigenetics and DNA methylation, folate and B vitamins research, birth, development, and health, prenatal screening and diagnostics, genetic syndromes and imprinting, the effects and risks of endocrine disrupting chemicals, and testicular diseases and treatments.

Jacquetta M. Trasler has published in various scientific venues, with frequent contributions to:

  • Andrology
  • Clinical Epigenetics
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Biological Psychiatry
  • American Journal of Clinical Nutrition

Recent notable papers include:

  • Knowledge gaps in understanding the metabolic and clinical effects of excess folates/folic acid: a summary, and perspectives, from an NIH workshop (2020) - American Journal of Clinical Nutrition
  • Impact of mothers' early life exposure to low or high folate on progeny outcome and DNA methylation patterns (2020) - Current Zoology
  • Frequency, morbidity and equity - the case for increased research on male fertility (2023) - Nature Reviews Urology
  • Whole-genome sequencing of H3K4me3 and DNA methylation in human sperm reveals regions of overlap linked to fertility and development (2021) - Cell Reports
  • The Association between Long-Term DDT or DDE Exposures and an Altered Sperm Epigenome-a Cross-Sectional Study of Greenlandic Inuit and South African VhaVenda Men (2024) - Environmental Health Perspectives

The scientist has collaborated frequently with several co-authors including Donovan Chan, Sarah Kimmins, Amanda J MacFarlane, Josée Martel, and William D. Fraser. Their collaborations highlight a robust network within the fields of molecular and reproductive biology.

Best Publications

  • Genomic imprinting disrupted by a maternal effect mutation in the Dnmt1 gene

    Carina Y. Howell;Timothy H. Bestor;Feng Ding;Keith E. Latham

  • Gene-specific timing and epigenetic memory in oocyte imprinting

    Diana Lucifero;Mellissa R.W. Mann;Marisa S. Bartolomei;Jacquetta M. Trasler

  • Methylation Dynamics of Imprinted Genes in Mouse Germ Cells

    Diana Lucifero;Carmen Mertineit;Carmen Mertineit;Carmen Mertineit;Hugh J. Clarke;Hugh J. Clarke;Hugh J. Clarke;Timothy H. Bestor;Timothy H. Bestor;Timothy H. Bestor

  • Disruption of histone methylation in developing sperm impairs offspring health transgenerationally

    Keith Siklenka;Serap Erkek;Serap Erkek;Maren Godmann;Romain Lambrot

  • Sex-specific exons control DNA methyltransferase in mammalian germ cells

    Carmen Mertineit;Jeffrey A. Yoder;Teruko Taketo;Dale W. Laird

  • Rare congenital disorders, imprinted genes, and assisted reproductive technology.

    Roger Gosden;Jacquetta Trasler;Diana Lucifero;Malcolm Faddy

  • Transcription factor GATA-4 is expressed in a sexually dimorphic pattern during mouse gonadal development and is a potent activator of the Müllerian inhibiting substance promoter

    Robert S. Viger;Carmen Mertineit;Jacquetta M. Trasler;Mona Nemer

  • Acquisition of the H19 methylation imprint occurs differentially on the parental alleles during spermatogenesis.

    Tamara L. Davis;Jacquetta M. Trasler;Stuart B. Moss;Grace J. Yang

  • Superovulation alters the expression of imprinted genes in the midgestation mouse placenta

    Amanda L. Fortier;Flavia L. Lopes;Nicole Darricarrère;Josée Martel

  • Developmental acquisition of genome-wide DNA methylation occurs prior to meiosis in male germ cells.

    C.C. Oakes;D.J. Smiraglia;B. Robaire

  • Potential significance of genomic imprinting defects for reproduction and assisted reproductive technology

    Diana Lucifero;J.Richard Chaillet;Jacquetta M. Trasler

  • Dramatically Different Phenotypes in Mouse Models of Human Tay-Sachs and Sandhoff Diseases

    Daniel Phaneuf;Nobuaki Wakamatsu;Jing-Qi Huang;Anita Borowski

  • Dynamics of Dnmt1 methyltransferase expression and intracellular localization during oogenesis and preimplantation development.

    Sarayu Ratnam;Carmen Mertineit;Feng Ding;Carina Y. Howell

  • Paternal cyclophosphamide treatment of rats causes fetal loss and malformations without affecting male fertility

    Jacquetta M. Trasler;Barbara F. Hales;Bernard Robaire

  • Windows for sex-specific methylation marked by DNA methyltransferase expression profiles in mouse germ cells

    Carmen Mertineit;Teruko Taketo;Peter B Moens

  • Aging results in hypermethylation of ribosomal DNA in sperm and liver of male rats

    Christopher C. Oakes;Dominic J. Smiraglia;Christoph Plass;Jacquetta M. Trasler;Jacquetta M. Trasler

  • Chronic low dose cyclophosphamide treatment of adult male rats: effect on fertility, pregnancy outcome and progeny.

    Jacquetta M. Trasler;Barbara F. Hales;Bernard Robaire

  • Apoptotic Cell Death in Mouse Models of GM2 Gangliosidosis and Observations on Human Tay-Sachs and Sandhoff Diseases

    Jing-Qi Huang;Jacquetta M. Trasler;Suleiman Igdoura;Jean Michaud

  • A unique configuration of genome-wide DNA methylation patterns in the testis

    C. C. Oakes;D. J. Smiraglia;B. Robaire

  • Gamete imprinting: setting epigenetic patterns for the next generation

    Jacquetta M. Trasler

Frequent Co-Authors

Louis Hermo
Louis Hermo McGill University
Jay M. Baltz
Jay M. Baltz Ottawa Hospital
Timothy H. Bestor
Timothy H. Bestor Columbia University
William D. Fraser
William D. Fraser Université de Sherbrooke
Rima Rozen
Rima Rozen McGill University
Grant A. Mitchell
Grant A. Mitchell University of Montreal
Daniel G. Cyr
Daniel G. Cyr University of Quebec
Tomi Pastinen
Tomi Pastinen Children's Mercy Hospital
Marisa S. Bartolomei
Marisa S. Bartolomei University of Pennsylvania
Christoph Plass
Christoph Plass German Cancer Research Center

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