World's Best Scientists 2026 revealed!

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Medicine

D-Index
80
Citations
35768
World Ranking
16903
National Ranking
708

Research.com Recognitions

  • 2010 - Fellow of the Royal Society of Canada Academy of Science
  • 2003 - Member of the European Academy of Sciences

Overview

Rima Rozen is affiliated with McGill University in Canada and has an extensive research background primarily in the field of Medicine. Their work focuses significantly on folate and B vitamins research, birth, development, and health, as well as studies related to pregnancy and preeclampsia. Other areas of interest include metabolism and genetic disorders and biomarkers related to GDF15.

Their publication record includes research articles mostly appearing in the journals Nutrients and the Journal of Nutrition. Frequent publication venues include:

  • Nutrients (3 publications)
  • Journal of Nutrition (1 publication)

Notable recent papers by Rima Rozen include:

  • "Moderate Folic Acid Supplementation in Pregnant Mice Results in Altered Sex-Specific Gene Expression in Brain of Young Mice and Embryos," 2022, Nutrients
  • "Mild Choline Deficiency and MTHFD1 Synthetase Deficiency Interact to Increase Incidence of Developmental Delays and Defects in Mice," 2021, Nutrients
  • "Folic Acid and Methyltetrahydrofolate Supplementation in the Mthfr677C>T Mouse Model with Hepatic Steatosis," 2024, Nutrients
  • "Contrasting Effects of Phosphatidylcholine and Betaine Supplementation on Embryonic Development in a Mouse Model of the MTHFD1 R653Q Variant," 2025, Journal of Nutrition

Rima Rozen has collaborated frequently with several coauthors, including:

  • Olga Malysheva
  • Marie A. Caudill
  • Karen E. Christensen
  • Yan Luan
  • Daniel Leclerc

Their research encompasses a variety of subfields related to medicine, such as:

  • Rheumatology
  • Pediatrics, Perinatology and Child Health
  • Obstetrics and Gynecology
  • Clinical Biochemistry

Rima Rozen's contributions have been recognized through several awards, including:

  • Fellow of the Royal Society of Canada, 2010 (Academy of Science)
  • Member of the European Academy of Sciences, 2003

Best Publications

  • A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase

    P. Frosst;H. J. Blom;R. Milos;P. Goyette

  • Relation Between Folate Status, a Common Mutation in Methylenetetrahydrofolate Reductase, and Plasma Homocysteine Concentrations

    P. F. Jacques;A. G. Bostom;R. R. Williams;R. C. Ellison

  • A Second Genetic Polymorphism in Methylenetetrahydrofolate Reductase (MTHFR) Associated with Decreased Enzyme Activity

    Ilan Weisberg;Pamela Tran;Benedicte Christensen;Sahar Sibani

  • Human methylenetetrahydrofolate reductase: isolation of cDNA, mapping and mutation identification

    Philippe Goyette;James S. Sumner;Renate Milos;Alessandra M.V. Duncan

  • Mutated methylenetetrahydrofolate reductase as a risk factor for spina bifida

    N.M.J. van der Put;F.J.M. Trijbels;L.P. van den Heuvel;H.J. Blom

  • Methylenetetrahydrofolate Reductase Polymorphism, Dietary Interactions, and Risk of Colorectal Cancer

    Jing Ma;Meir J. Stampfer;Edward Giovannucci;Carmen Artigas

  • Molecular genetic analysis in mild hyperhomocysteinemia: a common mutation in the methylenetetrahydrofolate reductase gene is a genetic risk factor for cardiovascular disease.

    L. A. J. Kluijtmans;L. P. W. J. Van Den Heuvel;G. H. J. Boers;P. Frosst

  • Mice deficient in methylenetetrahydrofolate reductase exhibit hyperhomocysteinemia and decreased methylation capacity, with neuropathology and aortic lipid deposition

    Zhoutao Chen;Andrew C. Karaplis;Susan L. Ackerman;Igor P. Pogribny

  • Methylenetetrahydrofolate Reductase Polymorphism, Plasma Folate, Homocysteine, and Risk of Myocardial Infarction in US Physicians

    J. Ma;Meir Stampfer;C. H. Hennekens;P. Frosst

  • A common variant in methionine synthase reductase combined with low cobalamin (vitamin B12) increases risk for spina bifida.

    Aaron Wilson;Aaron Wilson;Robert Platt;Robert Platt;Qing Wu;Daniel Leclerc

  • The structure and properties of methylenetetrahydrofolate reductase from Escherichia coli suggest how folate ameliorates human hyperhomocysteinemia.

    Brian D. Guenther;Christal A. Sheppard;Pamela Tran;Rima Rozen

  • Human methionine synthase: cDNA cloning and identification of mutations in patients of the cblG complementation group of folate/cobalamin disorders.

    D. Leclerc;E. Campeau;P. Goyette;C. E. Adjalla

  • Polymorphisms in genes involved in folate metabolism as maternal risk factors for Down syndrome.

    Charlotte A. Hobbs;Stephanie L. Sherman;Ping Yi;Sarah E. Hopkins

  • Effects of common polymorphisms on the properties of recombinant human methylenetetrahydrofolate reductase

    Kazuhiro Yamada;Zhoutao Chen;Rima Rozen;Rowena G. Matthews

  • Gene structure of human and mouse methylenetetrahydrofolate reductase (MTHFR)

    Philippe Goyette;Aditya Pai;Renate Milos;Phyllis Frosst

  • A rapid procedure for extracting genomic DNA from leukocytes

    S.W.M. John;G. Weitzner;R. Rozen;C.R. Scriver

  • The 1298A-->C polymorphism in methylenetetrahydrofolate reductase (MTHFR): in vitro expression and association with homocysteine.

    Ilan S. Weisberg;Paul F. Jacques;Jacob Selhub;Andrew G. Bostom

  • Genetic predisposition to hyperhomocysteinemia: deficiency of methylenetetrahydrofolate reductase (MTHFR).

    Rima Rozen

  • Socio-economic disparities in preterm birth: causal pathways and mechanisms.

    Michael S. Kramer;Lise Goulet;John Lydon;Louise Séguin

  • Mutated methylenetetrahydrofolate reductase as a risk factor for spina bifida [short report]

    N.M.J. van der Put;R.P.M. Steegers-Theunissen;P. Frosst;J.M.F. Trijbels

Frequent Co-Authors

Jacob Selhub
Jacob Selhub Tufts University
Robert W. Platt
Robert W. Platt McGill University
David S. Rosenblatt
David S. Rosenblatt McGill University
Charles R. Scriver
Charles R. Scriver McGill University
Teodoro Bottiglieri
Teodoro Bottiglieri Baylor University
Jacques Genest
Jacques Genest McGill University Health Centre
Michael S. Kramer
Michael S. Kramer McGill University
Henk J. Blom
Henk J. Blom Erasmus MC
Richard H. Finnell
Richard H. Finnell Baylor College of Medicine
Stepan Melnyk
Stepan Melnyk University of Arkansas for Medical Sciences

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