His primary areas of study are Homocysteine, Internal medicine, Endocrinology, Methylenetetrahydrofolate reductase and Risk factor. Henk J. Blom studies Homocysteine, namely Hyperhomocysteinemia. Henk J. Blom combines subjects such as Gastroenterology and Genotype with his study of Internal medicine.
The study incorporates disciplines such as Neural tube, Reductase and Vascular disease in addition to Endocrinology. The various areas that he examines in his Methylenetetrahydrofolate reductase study include Thermolabile, Methotrexate, Rheumatoid arthritis and Point mutation. His Risk factor study combines topics in areas such as Dydrogesterone, Central nervous system disease, Postmenopausal women, Case-control study and Mutation.
The scientist’s investigation covers issues in Internal medicine, Homocysteine, Endocrinology, Hyperhomocysteinemia and Methylenetetrahydrofolate reductase. His biological study deals with issues like Genotype, which deal with fields such as Allele. His research investigates the connection between Homocysteine and topics such as Cystathionine beta synthase that intersect with problems in Mutation.
His Endocrinology research focuses on Methylation and how it relates to Molecular biology. His work carried out in the field of Hyperhomocysteinemia brings together such families of science as Thrombosis, Venous thrombosis, Surgery and Cardiology. His Methylenetetrahydrofolate reductase research integrates issues from Reductase and Mutation.
His main research concerns Internal medicine, Homocysteine, Endocrinology, Biochemistry and Methionine. His Internal medicine research includes themes of Gastroenterology, Genetics and Hypermethioninemia. He is involved in the study of Homocysteine that focuses on Hyperhomocysteinemia in particular.
His Hyperhomocysteinemia research incorporates themes from Pregnancy, Nitric oxide, Surgery and Osteoporosis. His Endocrinology study incorporates themes from Methylation, Cerebrospinal fluid and Dimethylglycine. His Methionine study combines topics from a wide range of disciplines, such as Epilepsy, Bioinformatics and Pathology.
His primary areas of investigation include Internal medicine, Endocrinology, Homocysteine, Methionine and Methylenetetrahydrofolate reductase. The Internal medicine study combines topics in areas such as Hypermethioninemia, Genetics, Gastroenterology, Enzyme and Epilepsy. His research in Endocrinology intersects with topics in Neural tube, Missense mutation, Biochemistry and DNA methylation.
His study of Hyperhomocysteinemia is a part of Homocysteine. In Hyperhomocysteinemia, he works on issues like B vitamins, which are connected to Histone arginine methylation, Protein methylation and Histone methylation. Henk J. Blom works mostly in the field of Methylenetetrahydrofolate reductase, limiting it down to topics relating to Risk factor and, in certain cases, Surgery, Adverse effect and Mendelian Randomization Analysis, as a part of the same area of interest.
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A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase
P. Frosst;H. J. Blom;R. Milos;P. Goyette.
Nature Genetics (1995)
A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects?
Nathalie M.J. van der Put;Fons Gabreëls;Erik M.B. Stevens;Jan A.M. Smeitink.
American Journal of Human Genetics (1998)
Lowering blood homocysteine with folic acid based supplements: Meta-analysis of randomised trials
L.E. Brattstrom;M. den Heijer;H.J. Blom;G. Bos.
BMJ (1998)
Hyperhomocysteinemia as a risk factor for deep-vein thrombosis
M. Den Heijer;T. Koster;H. J. Blom;G. M. J. Bos.
The New England Journal of Medicine (1996)
MTHFR 677C-->T polymorphism and risk of coronary heart disease: a meta-analysis.
Mariska Klerk;Petra Verhoef;Robert Clarke;Henk J. Blom.
JAMA (2002)
Mutated methylenetetrahydrofolate reductase as a risk factor for spina bifida
N.M.J. van der Put;F.J.M. Trijbels;L.P. van den Heuvel;H.J. Blom.
The Lancet (1995)
Molecular genetic analysis in mild hyperhomocysteinemia: a common mutation in the methylenetetrahydrofolate reductase gene is a genetic risk factor for cardiovascular disease.
L. A. J. Kluijtmans;L. P. W. J. Van Den Heuvel;G. H. J. Boers;P. Frosst.
American Journal of Human Genetics (1996)
Neural tube defects and folate: case far from closed
Henk J. Blom;Gary M. Shaw;Martin den Heijer;Richard H. Finnell.
Nature Reviews Neuroscience (2006)
Thermolabile 5,10-methylenetetrahydrofolate reductase as a cause of mild hyperhomocysteinemia.
Astrid M. T. Engbersen;Diana G. Franken;Godfried H. J. Boers;Erik M. B. Stevens.
American Journal of Human Genetics (1995)
Maternal hyperhomocysteinemia : a risk factor for neural-tube defects ?
Régine P.M. Steegers-Theunissen;Godfried H.J. Boers;Frans J.M. Trijbels;James D. Finkelstein.
Metabolism-clinical and Experimental (1994)
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